[PDF] Top 20 Functional Analysis of the Human Immunodeficiency Virus Type 1 Rev Protein Oligomerization Interface
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Functional Analysis of the Human Immunodeficiency Virus Type 1 Rev Protein Oligomerization Interface
... of virus replication was seen during the experiments (up to 11 days ...these virus challenge experiments were designed to achieve maximal virus ...The virus titers used (2,000 TCID) are ... See full document
10
Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vif Protein
... proteins Rev and Tat (17, ...wild type to mutated ...of virus produced in the presence of the wild-type protein alone (data not ... See full document
7
RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo.
... sequester Rev (29, 30), or transdomi- nant Rev proteins to inhibit Rev function (1, 14, 21, 34, ...that Rev re- sponsiveness may be more refractive to the evolution of resis- tance than ... See full document
9
Diminished Rev-Mediated Stimulation of Human Immunodeficiency Virus Type 1 Protein Synthesis Is a Hallmark of Human Astrocytes
... Fluorescence microscopy and imaging of living cells. Microscopy of fixed and living cells expressing GFP fusion proteins was performed as described exten- sively in reference 23. For GFP analysis in living cells, ... See full document
11
The Rev protein of human immunodeficiency virus type 1 counteracts the effect of an AU-rich negative element in the human papillomavirus type 1 late 3' untranslated region.
... Human immunodeficiency virus type 1 (HIV-1) is the etio- logic agent of ...and Rev, regulate gene expression and are essential for replication of the ...while Rev ... See full document
14
Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase
... the oligomerization status of IN. Detailed biochemical and genetic analysis indicates that IN proteins form multimers; however, the number of monomers involved and the conditions under which different-order ... See full document
10
Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5
... ficiency virus (FIV). The FIV Vif protein interacts with Cullin (CUL), Elongin B (ELOB), and Elongin C (ELOC) to form an E3 ubiquitination complex to induce the degrada- tion of feline ...the ... See full document
15
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.
... Plasmid pIW15 represents a Rev trans-activator protein which exerts Rev activity via an activation domain originating from HTLV-I Rex, while the Rex derivative pIW17 acts on the HTLV-I R[r] ... See full document
5
Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex.
... As demonstrated previously 21, the protein encoded by Rex[vNLS33-46] was directed to the correct nucleolar compartment by a stretch of 14 amino acid residues Rev amino acid residues 33 t[r] ... See full document
5
Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles
... The oligomerization feature of Vpr was evaluated by using a complementation system based on Venus protein as a ...Venus-Vpr protein has allowed us to monitor oli- gomerization in live ...the ... See full document
11
The Carboxy-Terminal Region of the Human Immunodeficiency Virus Type 1 Protein Rev Has Multiple Roles in Mediating CRM1-Related Rev Functions
... the Rev C-terminal region in Rev- Rev ...Rex protein, a functional homolog of HIV-1 Rev, uses hCRM1 not only for nuclear export but also for Rex-Rex dimerization (23, ... See full document
11
Nucleoporins Nup98 and Nup214 Participate in Nuclear Export of Human Immunodeficiency Virus Type 1 Rev
... is human im- munodeficiency virus type 1 (HIV-1) Rev, which is responsible for the export of the Rev-responsive element containing viral ...of Rev of HIV-1 ... See full document
8
Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein.
... regulatory protein of human immunodeficiency virus type 1, has been demonstrated to shuttle between the nucleus and cytoplasm of infected ...the Rev protein in ... See full document
8
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
... The hybrid protein bearing the basic domain of the visna virus Rev protein and the leucine domain of HIV-1 Rev, termed L/Rev, proved fully able to trans activate visna virus structural p[r] ... See full document
5
Structural and functional analysis of the human immunodeficiency virus type 2 Rev protein.
... Structural and functional characterization of HIV-2 Rev protein mutants Plasmid Mutationa pSV2neo BLpSVHIV-2Rev BLpSVA35-37 BLpSVA39-43 BLpSVA43-49 BLpSVA46-49 BLpSVA61-64 BLpSVA73-74 BL[r] ... See full document
5
Oligomerization of the human immunodeficiency virus type 1 (HIV 1) Vpu protein – a genetic, biochemical and biophysical analysis
... Vpu protein binds CD4 in the endoplasmic reticulum (ER) [9], and through its phos- phoserine residues binds the beta transducin-repeat con- taining protein (βTrCP) in the cytoplasm ...enhances virus ... See full document
11
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus.
... The Rev protein sequence encoded by pRSV-Rev is that of HIV-1 strain BRU 33; in this sequence, positions 7 to 11 are occupied by a cluster of acidic amino acids that includes one of the [r] ... See full document
7
Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.
... of Rev changes. Because DNA sequence analysis demonstrated that the MA Rev activation domains carried a unique Leu-783Ile substitution, the possi- bility that a Rev malfunction was responsible ... See full document
11
Functional Analysis of Vif Protein Shows Less Restriction of Human Immunodeficiency Virus Type 2 by APOBEC3G
... acid protein conserved in all known lentiviruses with the ex- ception of equine infectious anemia virus ...(35). Functional studies on Vif1 established that it acts during the late stage of viral ... See full document
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
... WT virus, but with a delay of 4 days ...modest virus assembly defects in the 293T overexpression system, have even more severe phe- notypes in peripheral blood mononuclear cells or T cells ...Viral ... See full document
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