[PDF] Top 20 Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV
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Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV
... 2158 binding. We first tested MAb 2158’s binding dependency on N160 and I161, located at the N terminus of this region, by independently introducing N160K and N160K/I161V ...of binding compared to ... See full document
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Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL
... attain binding saturation of the virus Env due to the relative distance of its epitope from the sur- rounding ...CD4 binding and also affected by the removal of N-glycan from residue 301 at the base of V3, ... See full document
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A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein
... 4. Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S. 2009. The spike protein of SARS-CoV–a target for vaccine and therapeutic development. Nat. Rev. Microbiol. 7:226 –236. http://dx.doi.org/10.1038/nrmicro2090. 5. Mailles A, ... See full document
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V3 specific neutralizing antibodies in sera from HIV 1 gp160 immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation dependent CD4 binding site of gp120 NIH NIAID AIDS Vaccine Clinical Trials Network
... sion-inhibition antibodies were studied further. In competitive antibody binding experiments, antibodies reactive with the con- formation-dependent, CD4 binding site of gpl 20 were undet[r] ... See full document
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Functional Mimicry of a Human Immunodeficiency Virus Type 1 Coreceptor by a Neutralizing Monoclonal Antibody
... tibody binding and CCR5 recognition can be separated in the context of a functional HIV-1 envelope ...glycoprotein. Functional mimicry of the CCR5 N terminus by the 412 ...indicated ... See full document
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An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum
... a conformation gp120 determinant that involves the C1 region ...the antibody does not bind to the native trimer ...of HIV-1-infected cells. Moreover, these data suggest that the conformation ... See full document
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A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody.
... A potent, neutralizing human monoclonal antibody against a unique epitope overlapping the CD4-binding site of HIV-1 gpl20 that is broadly conserved across North American and African viru[r] ... See full document
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Antibody-Dependent Cellular Cytotoxicity against Primary HIV-Infected CD4+ T Cells Is Directly Associated with the Magnitude of Surface IgG Binding
... IgG binding. Although modification of the Fc to enhance Fc␥RIII binding increased ADCC activity, it did not attain the level of complex ...FcR binding but, rather, is at the level of antigen-specific ... See full document
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Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies
... the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been studied extensively for their ability to block viral infectivity, little data are currently available on nonneutralizing ... See full document
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Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes
... of HIV entry pos- tulates that gp41 undergoes major refolding steps as it medi- ates membrane fusion ...fusion-active conformation consisting of a thermostable six-helix bundle structure ...gp120 ... See full document
5
Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site.
... IgG1b12 antibody; and Mary Racho for valu- able technical ...of HIV-1, mouse MAb 0.5 b , and human HIV immunoglobulin were obtained from the NIH AIDS Research and Reference Reagent Program; ... See full document
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Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner
... anti-V2 monoclonal antibodies (MAbs), we tested whether they can mediate Ab-dependent cellular phagocytosis (ADCP), which is an important element of anti-HIV-1 ...chronically ... See full document
13
Mode of inhibition of HIV 1 Integrase by a C terminal domain specific monoclonal antibody*
... of HIV-1 integrase (IN) we developed and characterized a library of monoclonal antibodies (mAbs) directed against this ...inhibit HIV-1 IN processing activity in vitro; a corresponding Fv ... See full document
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Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin binding adhesins fibronectin binding protein A and fibronectin binding protein B from Staphylococcus aureus
... the antibody epitope to the N-terminal segment and the fibronectin-binding site to the C-terminal segment of the ...the antibody might result from steric hindrance or a conforma- tional change in the ... See full document
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Differences in the Binding Affinity of an HIV 1 V2 Apex Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody Dependent Cellular Cytotoxicity from Neutralization
... of HIV-1 and SIV smm/mac and to the rapid evolution of their viral envelope glycoproteins in response to host immune responses, antibodies to the HIV-1 Env protein, including broadly neutralizing antibod- ... See full document
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A new murine monoclonal antibody reports an activation dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex
... B S Coller J Clin Invest. 1985;76(1):101-108. https://doi.org/10.1172/JCI111931. Considerable evidence indicates that the glycoprotein (GP) IIb/IIIa complex on human platelets functions as a receptor for ... See full document
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Deficient Antibody-Dependent Cellular Cytotoxicity against Human Immunodeficiency Virus (HIV)-Expressing Target Cells in Perinatal HIV Infection
... of human immunodeficiency virus (HIV)-infected children, age-matched HIV-seronegative controls, and HIV-infected asymptomatic and symptomatic adults were com- pared for their ability to ... See full document
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Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1.
... A conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody. Walker (ed.), Techniques in H[r] ... See full document
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Functional assessment and structural basis of antibody binding to human papillomavirus capsid
... the neutralization mechanism and the specific binding sites of neutralizing mAbs. 372[r] ... See full document
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Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells
... between antibody-dependent NK cell acti- vation (with background subtracted) against reactivated ACH-2 cells and against unactivated ACH-2 ...an antibody- dependent manner. ... See full document
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