[PDF] Top 20 Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis.
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Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis.
... Simian virus 40 early promoter expression vectors for the HBV S protein (pSVBX24H) (14), for the simultaneous expression of L, M, and S proteins (pSV45H) (24), and for the expression of M ... See full document
6
The Pre-S2 Domain of the Hepatitis B Virus Is Dispensable for Infectivity but Serves a Spacer Function for L-Protein-Connected Virus Assembly
... of pre-S1 and pre-S2 (designated HBV L ⫺ M ⫺ ), or a derivative of L ⫺ M ⫺ with an artificially introduced stop codon (TCA to TAA) at position 6 of the S ORF (desig- nated HBV L ⫺ M ⫺ S ⫺ ...L ... See full document
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Infectivity Determinants of the Hepatitis B Virus Pre-S Domain Are Confined to the N-Terminal 75 Amino Acid Residues
... Hepatitis B virus (HBV) is characterized by a narrow host range that reflects the specificity of interaction between enve- lope proteins and human hepatocyte receptors at viral entry ...designated ... See full document
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Efficient Inhibition of Hepatitis B Virus Infection by Acylated Peptides Derived from the Large Viral Surface Protein
... the large (L), middle (M), and small (S) surface ...hydrophobic S domain serves as a mem- brane anchor and plays important roles in virus assembly (3) and possibly membrane ... See full document
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An 80-Kilodalton Protein That Binds to the Pre-S1 Domain of Hepatitis B Virus
... that hepatitis B virus (HBV) binds to a receptor on the plasma membrane of human hepatocytes via the pre-S1 domain of the large envelope protein as an initial step in HBV ... See full document
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Hepatitis B Virus Subviral Envelope Particle Morphogenesis and Intracellular Trafficking
... the surface proteins are not only incorporated into virion en- velopes but they also bud to generate empty subviral spherical or filamentous particles without nucleocapsids in an intracel- lular compartment, with ... See full document
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The First Transmembrane Domain of the Hepatitis B Virus Large Envelope Protein Is Crucial for Infectivity
... L protein S domain did not affect par- ticle assembly except for one mutation, LM ⌬ (I188/I191), which prevented complete viral particle secretion ...the virus titer depends on the ... See full document
11
Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction
... termed large (L), middle (M), and small (S) ...outer virus shell, which is embedded in an endoplasmic reticulum (ER)-derived lipid ...and S proteins share the C-terminal 226 amino acids ... See full document
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Mapping of the Hepatitis B Virus Pre-S1 Domain Involved in Receptor Recognition
... The hepatitis B virus (HBV) genome is a relaxed-circular, partially duplex DNA with a covalently attached polymerase that displays reverse transcriptase activities (40, ...and large (L) ... See full document
13
Topology of the large envelope protein of duck hepatitis B virus suggests a mechanism for membrane translocation during particle morphogenesis.
... of virus enve- lope caused by low pH, we tested the integrity of the DHBV envelope by using three different ...core particle DNA in enveloped particles to DNase I in the pres- ence of pronase ...core ... See full document
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Dual topology of the large envelope protein of duck hepatitis B virus: determinants preventing pre-S translocation and glycosylation.
... the large envelope protein (L protein) of hepadnaviruses was investigated using the duck hepatitis B virus (DHBV) model, which also allows the study of hepadnavirus ... See full document
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Molecular Chaperone GRP78/BiP Interacts with the Large Surface Protein of Hepatitis B Virus In Vitro and In Vivo
... The hepatitis B virus (HBV) is a noncytopathic double- stranded DNA virus of the hepadnavirus family that causes acute and chronic liver ...enveloped virus whose envelope consists of ... See full document
5
A Hydrophobic Domain in the Large Envelope Protein Is Essential for Fusion of Duck Hepatitis B Virus at the Late Endosome
... to virus is sufficient time for internal- ization of most of the attached particles from the cell ...the S domain, indicated by an ...of virus derived from LMH transfected cells, as ... See full document
11
The large surface protein of duck hepatitis B virus is phosphorylated in the pre-S domain.
... DISCUSSION The data presented here clearly demonstrate that a proportion of the large envelope protein of DHBV is modified by phosphorylation of serine and/or threonine residues within t[r] ... See full document
7
A short linear sequence in the pre-S domain of the large hepatitis B virus envelope protein required for virion formation.
... The pre-S2 domain contains another N-glycosylation site at Asn 4 which is used only in the case of the M protein ...L protein. The M and S proteins were expressed from their autologous ... See full document
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Inhibition of Duck Hepatitis B Virus Infection by a Myristoylated Pre-S Peptide of the Large Viral Surface Protein
... immunodeficiency virus envelope protein-derived peptides have similarly been shown to be capable of efficiently inhibiting the entry of this virus into its host ...defined domain of the ... See full document
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Role of the Pre-S2 Domain of the Large Envelope Protein in Hepatitis B Virus Assembly and Infectivity
... mutant pre-S1-pre-S2-S genes. The amount of viral surface proteins synthesized in transfected cells was too weak to be detectable under our Western blot conditions (data not ...of ... See full document
6
Characterization of the major duck hepatitis B virus core particle protein.
... DHBcAg polypeptide exhibits heterogeneity in SDS-PAGE that can be completely removed following treatment of native core particles with alkaline phosphatase Fig.. 3, suggesting that the p[r] ... See full document
6
Mapping of Functional Subdomains in the Terminal Protein Domain of Hepatitis B Virus Polymerase
... TP domain, all known HBV (n ⫽ 583) and DHBV (n ⫽ 45) sequences with a complete TP domain were aligned to derive a consensus sequence for each ...TP domain of both HBV and DHBV P ...TP domain ... See full document
15
Selective synthesis and secretion of particles composed of the hepatitis B virus middle surface protein directed by a recombinant vaccinia virus: induction of antibodies to pre-S and S epitopes.
... 4 0022-538X/87/041286-05$02.00/0 Copyright © 1987, American Society for Microbiology Selective Synthesis and Secretion of Particles Composed of the Hepatitis B Virus Middle Surface Prote[r] ... See full document
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