[PDF] Top 20 Galectin-9 Functionally Impairs Natural Killer Cells in Humans and Mice

... for humans, we find that the genetic absence of galectin-9 in mice is associ- ated with greater IFN- ␥ production by NK cells and enhanced ...of galectin-9 knockout ... See full document

... Here, we examined the expression level of cis -NATs using SAGE tags and oligonucleotide arrays in public databases. We obtained the same distribution of the expression level of cis -NATs at least in the same tissue or ... See full document

... NK cells, patients with antibiotic-responsive arthritis had higher frequencies of iNKT cells in SF than PB, but these cells were often absent in SF in patients with antibiotic-refractory ...iNKT ... See full document

... NK cells has not been well ...which mice were given high levels of alcohol (20%, w/v) in their drinking water showed inhibition of NK cell cytolytic activity ...in mice. As- sessments of NK cell ... See full document

... host cells is tightly regulated by several cellular ...in mice using MCMV have convincingly shown that NKG2D ligand downregulation is of vital importance for the virus to be able to replicate and spread in ... See full document

... uNK cells Similar to humans, the pregnant mouse also develops a he- mochorial placenta to support embryo development and evades a destructive immune response despite high accumulation of pregnancy-specific ... See full document

... target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced ...in humans, causing severe viral pneumonia leading to acute respiratory ... See full document

... NK cells may also contribute to overproduction of pro- inflammatory cytokines, which can result in immuno- pathology ...NK cells can also produce the anti-inflammatory cytokine IL-10, which limits immune ... See full document

... Briefly, mice were anesthetized, and the cecum was exposed, ligated with a 3–0 silk suture and punctured once with an 18-gauge ...All mice received a subcutaneous injection of 1 ml of sterile saline to ... See full document

... NK cells is controlled by a com- plex repertoire of activating and inhibitory signals generated by a multitude of receptors triggering cytotoxicity and the release of chemokines and ...NK cells must be ... See full document

... T cells may respond directly to pathogen associated molecular ...T cells play a prominent role in the immune response to mycobacterial ...in mice, γδ T cells were recruited to the lungs and ... See full document

... which natural killer (NK) cells are thought to play an important defensive ...NK cells were similar to that of blood (P greater than ...these cells (P less than ...NK cells to ... See full document

... NK cells with the most important CD107a upregulation were those with no or very low Tim-3 surface expression as a consequence of stimulation (Figure ...NK cells competes with the monoclonal antibody for ... See full document

... It is not fully elucidated yet, how iNKT cells inter- act with other parts of the immune system in SSc. However, they produce immunoregulatory cytokines influencing immune cell differentiation. The IL-23- Th17 ... See full document

... NK cells, influence subsequent adaptive immune ...abnormal cells and produce cytokines and chemokines, NK cells are positioned for a key role in regulating autoim- mune ...NK cells are ... See full document

... of natural cytotoxicity towards the classic NK cell target K562 in active ...endothelial cells [28]. Therefore, the reduced natural cytotoxicity towards K562 might be relevant in ...K562 cells ... See full document

... NK-92 cells designed to express the Fc receptor CD16 (FcgammaRIIIa) are enabled to kill through the mechanism of antibody-dependent cell- mediated cytotoxicity [70, 71], with the prospective to augment an- tibody ... See full document

... ural killer T (NKT) cells, a recently identified lymphoid cell lineage, are required for the acceptance of intrahepatic rat islet ...C57BL/6 mice, with no need for immunosuppressive ...NKT ... See full document

... Mechanism, Natural killer cell receptors, Tumour surveillance ABSTRACT An important component of the innate immune system, the natural killer cells that originate from the lymphoid cell ... See full document

... cell-deficient mice: a model for the study of ‘helpless’ CD8+ T cells, which resemble CTL in chronic infections in which pathogens are not cleared despite a robust CTL ... See full document