[PDF] Top 20 Gene-nutrient interactions and susceptibility to human obesity
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Gene-nutrient interactions and susceptibility to human obesity
... with obesity susceptibility gene variants inter- acting with an obesogenic environment to increase obes- ity, James ...during human evolution [64, ...of gene variants has occurred dur- ... See full document
9
Gene expression profiles of a mouse congenic strain carrying an obesity susceptibility QTL under obesigenic diets
... of obesity, likely through the interactions of susceptibility genes with obesigenic environments, such as high-fat, high-sucrose (HFS) ...an obesity quantitative trait locus (QTL), tabw2, ... See full document
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The Impact of Individual Human Immunodeficiency Virus Type 1 Protease Mutations on Drug Susceptibility Is Highly Influenced by Complex Interactions with the Background Protease Sequence
... ity of HIV, it is difficult to find the genetically related variants required for such a study in patient databases, even if they contain sequences from thousands of virus isolates. Traditional approaches utilizing ... See full document
9
Lipopolysaccharide-treated Human Monocytes Regulate Gene Expressions After Interactions with Human Adipocytes
... in human monocytes increased by interactions with cancer cells and that this increase can be suppressed by pretreatment with low-dose LPS ...LPS-treated human monocytes regulate inflammatory ... See full document
5
Analysis of the breast cancer susceptibility gene (BRCA1) region in human and mouse
... protein-protein interactions and indeed, a novel protein, BARDl, has been found to interact w ith BRCAl via the RING finger (Wu et ...rter gene and m ay provide a role for BRCAl in transcriptional control ... See full document
196
Gene-environment interactions and obesity: recent developments and future directions
... novel interactions, including the interactions between the LEPR rs12753193 and BMI on C-reactive protein levels, between the ICAM1 rs1799969 and smoking on intercellular adhesion mole- cule 1 (ICAM-1 ) ... See full document
6
The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus
... candidate gene approach, polymorphisms in sev- eral other immune response and cytokine genes have been implicated as genetic risk factors in certain ...of human type 1 and type 2 DM, is complex and it is ... See full document
6
Gene-Environment Interactions and Epigenetic Basis of Human Diseases
... against obesity and ...adipogenic gene activities during in vitro adipogenesis, including the adipose most abundant transcript 1 (apM1), the glucose transporter Glut4, and glycerol phosphate dehydrogenase ... See full document
14
Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario
... of human dis- eases, including cancer. The dramatic advances in human genome research coupled with the recent progress in high- throughput technology for molecular biology and genet- ics now allow the study ... See full document
15
Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions
... for Human and Machine Cognition to create a conceptual model of diet and health-related data that provides a foun- dation for future nutrigenomics ontologies describing pub- lished ...phenotype, nutrient, ... See full document
17
Original Article Association of estrogen receptor alpha gene polymorphisms and its gene-gene interactions with knee osteoarthritis susceptibility in Chinese Han population
... ESR1 gene were both associated with increased knee OA risk in Chinese ...the human ESR1 gene polymorphisms and knee OA risk, previously several studies were conducted to investigate this ... See full document
7
Automated nutrient screening system enables high-throughput optimisation of microalgae production conditions
... Table 2 shows the three highest growth rates (in bold) obtained for the eight species tested and the N and P conditions under which these were obtained. Closer ana- lysis shows that the relative standard deviation (RSD) ... See full document
17
Foliar Nutrient Balance Standards for Maize (Zea mays L ) at High Yield Level
... Therefore, nutrient balance standards reflected ex- ceptional climatic and soil conditions during those pro- ductive ...on nutrient balance targets to reach under the most favorable grow- ing ...validate ... See full document
11
LDGIdb: a database of gene interactions inferred from long range strong linkage disequilibrium between pairs of SNPs
... potential gene interactions at the protein and RNA level, ...incorporates human disease-association databases such as Genome-Wide Association Studies (GWAS) and Online Mendelian Inheritance in Man ... See full document
8
Genetic polymorphisms in the <em>TERT</em> gene and susceptibility to non-small cell lung cancer in a Chinese Han population
... However, one limitation that might have affected the results of the association study was the lack of smoking status data of the control individuals. This limitation made it difficult to perform a gene-smoking ... See full document
9
Identification of Novel Transcription Start Sites and Distinct Proximal Promoter Regions for Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2
... mouse gene has been disrupted and the human CYP gene has been introduced, express only human CYPs and have been very useful in the studies of human CYP1A, CYP3A4 and CYP2E1 induction, ... See full document
115
Characterizing human genomic coevolution in locus-gene regulatory interactions
... eQTL interactions, and we discovered that pairs of SNPs and genes that appear coevolved are enriched for eQTL ...eQTL interactions could be ...inter-chromosomal interactions such as trans-eQTL ... See full document
15
A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene
... a gene-breaking transposon–based (GBT- based) insertional mutagenesis screening platform in the scalable zebrafish (Danio rerio) model, we sought to develop a forward genetic approach for discover- ing CM genes ... See full document
14
Article: Association of MC4R codon 42 polymorphism with obese/diabetic ethnic Kashmiri population
... This study identifies sequence variants in MC4R gene in a pure ethnic Kashmiri population. Prior to DNA sequencing samples were screened for the presence of mutations by Conformation Sensitive Gel Electrophoresis ... See full document
9
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
... An integrated response: a role for cellular senescence in obesity. Recent studies have identified an important role for cellular senes- cence in many diseases including those associated with obesity. ... See full document
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