[PDF] Top 20 Global burden of drug-resistant tuberculosis in children: a mathematical modelling study

... paediatric tuberculosis incidence in China, India and Russia, without considering any differences in drug-resistance ...underlying burden estimates from Jenkins et ...a global estimate in the ... See full document

... of children with ...for children with tuberculosis who do not receive tuberculosis treatment were not available from recent studies, we assumed that these children had the same risk of ... See full document

... AND burden AND model* AND (“resist*” OR “multidrug*” OR “MDR-” OR drug-resistant)” for articles published in English up to Nov 1, ...total global latent tuberculosis infections and the ... See full document

... classify drug-resistant ...total burden of MDR/RR-TB at ...absolute burden of MDR/RR-TB at re-treatment should also be taken into account by users if they wished to estimate the absolute ... See full document

... 20 children sick with TB. Our study underlines the need in all settings to ascertain the likely drug-resistance profile of children with TB disease or latent ...Because children with TB ... See full document

... previous study provided estimates at the national level for more than 100 countries, detailed assessment of the dominant drug resistance pathways in specific settings would assist local control ...the ... See full document

... current study show that the prevalence of MDR/RR-TB at this major hospital in Guizhou Province is higher than the average number in the world and confirm the existence of heterogeneity in drug resistance ... See full document

... by modelling intermediate steps to ...in children can be compared with paediatric notifi cations to identify potential shortfalls in ...paediatric tuberculosis, and the data used as inputs for the ... See full document

... with Drug Sensitivity Testing (DST) are performed on all re-treatment cases, DR TB contacts, new under -treatment pulmonary TB patients who remain smear positive till the end of intensive phase, presumptive MDR, ... See full document

... Critical questions include the number of those with LTBI at highest risk of developing dis- ease, i.e., those infected within the past 2 y [12]. This population is a focus of proposed “test and treat” strategies in TB, ... See full document

... In addition, the ability to monitor enrollment and data entry targets in real time was an important feature of the study design. This allowed any problems with achieving enrollment goals to be addressed quickly ... See full document

... Original studies will be described using study charac- teristics summary table and forest plot. A meta-analysis, to compute a pooled estimate, will be performed if vari- ability among studies is low. However, if ... See full document

... one report describes this for Dlm [68], two reports for two cohorts receiving both Bdq and Dlm [23, 70], and one report describes the safety and efficacy of a modified STR in which kanamycin was replaced with Bdq [67]. ... See full document

... The equilibrium MDR-TB incidence and replacement time, respectively, as functions of the unsuccessful live outcome rate (i.e., default or failure) and the relative detection rates are shown in Figure 3. In these graphs ... See full document

... by drug susceptibility testing ...highly resistant cases in danger of resistance amplification to XDR-TB, without excessively delaying enrolment and start of ...nine-month study regimen drugs and ... See full document

... the study. It is a type of infection by mycobacterium tuberculosis which is resistant to one or more of the fi rst- line anti-TB ...the study were age, sex, educational status, address of the ... See full document

... a global cause for ...dormant tuberculosis bacteria and the person develops TB when the bacteria are no longer ...primary drug responsible for killing the bacilli, studies and research in the ... See full document

... anti- tuberculosis drugs (SLD's) like ethionamide / prothionamide, cycloserine, PAS, kanamycin / capreomycin ,flouroquinolones (levofloxacin, ofloxacin, moxifloxacin), clofazimine, macrolides ...suspected ... See full document

... Currently, drug susceptibility testing is not routinely performed on MTB isolates cultured from children and drug suscept- ibility testing of isolates in children with tuberculosis in ... See full document

... QT monitoring and the management of QT prolongation The inclusion in the STREAM regimen of high doses of moxifloxacin, which is known to cause QT prolongation [20], together with the fact that many of the patients would ... See full document