[PDF] Top 20 Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins
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Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins
... of NS2 and its interaction with both structural and nonstructural ...with NS2 but not NS3 ...of NS2 by altering its topology with respect to mem- ...that NS2 is a ... See full document
12
Yellow Fever Virus Replicons as an Expression System for Hepatitis C Virus Structural Proteins
... HCV structural proteins and possibly HCV assembly, chimeric YF/HCV ge- nomes were constructed in which the structural genes of YF- 17D were replaced by the structural genes of a ... See full document
5
Hepatitis C Virus Nonstructural Protein 5B Is Involved in Virus Morphogenesis
... HCV assembly and maturation steps had been poorly character- ...of virus assembly (24, 49, ...NS proteins NS2, NS3, NS4B, NS5A, and p7 are involved in HCV assembly and maturation ... See full document
9
Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
... of NS2, are also required for infectious HCV ...reporter virus, RNA ...reduced both intra- and extracellular infectivity ...core protein in supernatants derived from cells depleted of these ... See full document
21
NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies
... capsid protein maturation and lipid droplet targeting involved in particle morphogenesis (23–25) as well as the role of NS3-4A protease in disrupting host innate im- mune responses through the cleavage of the ... See full document
19
Genetic and Functional Characterization of the N-Terminal Region of the Hepatitis C Virus NS2 Protein
... for NS2, and this activity is dispensable for infectious virus production (13, 25, ...Thus, NS2 is hypoth- esized to regulate this process through modulating interactions between structural ... See full document
16
Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins
... NS5A with RNA and to elucidate the minimal requirements thereof. NS5A appears to exist in equilibrium between mono- mer and dimer, with the monomer being favored (Fig. 8). Binding of “specific” (G/U) RNA shifts the ... See full document
12
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
... Thus, structural integrity of each of these proteins, forming most likely a multisubunit protein complex, is essential for differential phosphorylation of ...an NS2-5B polyprotein were almost ... See full document
9
Determinants of the Hepatitis C Virus Nonstructural Protein 2 Protease Domain Required for Production of Infectious Virus
... Although NS2 expression and stability were not dramatically altered by most C-terminal substitutions, it is possible that deletion of L217 changes the structure of NS2 by liberating the C ... See full document
12
NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.
... HCV structural proteins, C-p7, in place of luciferase or NPT in the first ...when C-p7 is expressed from a replicating, NS2-deleted HCV RNA, which would otherwise ultimately be destined ... See full document
15
Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I
... inhibiting both IFN production and signal ...the C terminus of MDA-5 in order to block IFN induction ...(e.g., hepatitis C virus NS3/4A [12]) or even IRF3 itself (rotavirus NSP1 ...A ... See full document
9
Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus
... RNA virus containing an open reading frame (ORF) encoding a single polypeptide chain, which is cleaved into structural (core, E1, E2, and p7) and nonstructural (NS2, NS3, NS4A, NS4B, NS5A, and ... See full document
14
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
... HCV NS2/3 pro- tease, we propose that following co- and posttranslational pro- cessing of the amino terminal structural proteins, the rapid intramolecular cleaving reaction between NS2 and NS3 ... See full document
14
Minute Virus of Mice Small Nonstructural Protein NS2 Interacts and Colocalizes with the Smn Protein
... Recently, a novel subnuclear compartment has been identi- fied following infection by the two highly related parvoviruses MVM and H-1 (2, 9). This structure, termed autonomous parvovirus-associated replication (APAR) ... See full document
6
Nonstructural proteins NS2 of minute virus of mice associate in vivo with 14-3-3 protein family members.
... 32-kDa proteins with nonfunc- tional carboxy-terminally modified NS2 ...express NS2 or producing C-terminally modified NS2 proteins were deficient in the accumulation of viral ... See full document
8
In vitro study of the NS2-3 protease of hepatitis C virus.
... strictly structural role ...the structural integrity of the HCV ...the NS2-3 autoprotease activity ...the NS2-3 protease integrity and functionality remains to be ... See full document
8
Structural and Nonstructural Proteins of Saint Louis Encephalitis Virus
... Identification of the proteins synthesized in the infected cells as being viral structural or nonstructural was accomplished by co-electrophoresis of cytoplasmic extracts from 3H-amino a[r] ... See full document
10
Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3
... cellular proteins interacting with the NS5A protein by yeast two-hybrid screening of a human he- patocyte cDNA ...of proteins mediating transport of proteins and possibly RNAs ... See full document
9
The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3).
... of hepatitis C virus (HCV) nonstructural protein 3 (NS3), a polypeptide encompassing amino acids 1175 to 1657, which cover only the putative helicase domain, was expressed in ... See full document
8
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.
... In flavivirus, NS3 is necessary, but not sufficient, for processing at the nonstructural cleavage sites: in addition to the catalytic NS3 domain, NS2B is required for proteolytic activit[r] ... See full document
8
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