[PDF] Top 20 Hepatitis C Virus entry: the early steps in the viral replication cycle
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Hepatitis C Virus entry: the early steps in the viral replication cycle
... the viral replication ...RNA replication but not the whole viral rep- lication ...efficient replication of the HCV genome in vitro interfered with virus packaging and secre- tion ... See full document
11
Primary T cells from human CD4/CCR5 transgenic rats support all early steps of HIV 1 replication including integration, but display impaired viral gene expression
... HIV-1 replication in rodents manifest themselves at vari- ous steps of the viral replication ...of virus and host, and this work has resulted in a greater molecular understanding of ... See full document
16
Early Steps of the Virus Replication Cycle Are Inhibited in Prostate Cancer Cells Resistant to Oncolytic Vesicular Stomatitis Virus
... stomatitis virus (VSV) is currently being studied as a candidate oncolytic virus for tumor therapies due to its potent tumoricidal ...the viral replication cycle that is inhibited in ... See full document
12
Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype
... cell cycle progression were affected following HBV infection ...cell cycle control were altered ...cell cycle PCR array containing 84 key cell cycle-regulatory genes was utilized ...cell ... See full document
19
Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture
... the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high ... See full document
13
The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
... different steps of the coronavirus (CoV) infection ...impair entry but also RNA synthesis and subsequent protein expression of different CoVs ...mouse hepatitis virus [MHV], feline infectious ... See full document
11
Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication
... a viral trans-acting ...in viral life cycle re- mains largely ...HBV replication in tissue culture (29) but necessary for establishment of woodchuck hepatitis virus in- fection ... See full document
10
EWSR1 Binds the Hepatitis C Virus cis-Acting Replication Element and Is Required for Efficient Viral Replication
... epatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis, and hepatocellular ...RNA virus classified within the family Fla- viviridae. The viral genome encodes an open ... See full document
10
The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... eliminate viral components of HBV and blocks the viral life ...of viral proteins and contribute to viral ...both viral replication and hepatocarcinogenesis during HBV infection ... See full document
10
Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly
... cap-independent viral protein translation ...or viral genome ...in viral genome replication ...HCV replication while they are dispensable for an HCV subgenomic replicon lacking almost ... See full document
17
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses
... to virus invasion of target ...productive entry of HCV virus particles into Huh7-Lunet cells are in line with this model and suggests that interactions with a specific highly sulfated type of GAG may ... See full document
13
The Hepatitis E Virus Capsid C-Terminal Region Is Essential for the Viral Life Cycle: Implication for Viral Genome Encapsidation and Particle Stabilization
... The observation, via WB (Fig. 3A), of a “smear” of antigen with a maximum size of 55 kDa was unexpected, given that the capsid protein lacking C52aa (predicted size, 6 kDa) was expected to migrate at 66 kDa (that is, 72 ... See full document
6
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... wild-type virus with that of a virus that has a modest level of resistance to the PR inhibitor used ...wild-type virus would be more sensitive than the ...mutant virus (Table ...the ... See full document
5
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
... devoid of genomic RNA, we further investigated the subcellular colocalization of HCV proteins to determine whether this mutation would induce a mislocalization of the E1 glycoprotein. For this, Huh-7 cells were ... See full document
19
Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection
... examined virus budding and morphology on the surfaces of A431 cells and the A431-AnxA6 stable cell line after infection with influenza virus strain WSN at an MOI of 5 for 10 ...influenza virus WSN ... See full document
13
WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress
... HCMV replication by downregulating expression of viral early and late genes ...immediate early promoter (MIEP) ...the virus assembly compartment and entraps it in mature virions to ... See full document
19
Sigma-1 Receptor Regulates Early Steps of Viral RNA Replication at the Onset of Hepatitis C Virus Infection
... the hepatitis C virus life ...of viral RNA observed after infection of S1R-deficient cells ...RNA replication indicate that S1R is rate limiting for the initial steps of HCV RNA ... See full document
14
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production
... of viral pathogens is important for understanding viral characteristics and for developing antiviral ...strategies. Hepatitis C virus (HCV) is a major cause of chronic liver diseases ... See full document
16
The α Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation
... The roles of NS5A for viral replication and/or infection still remain a mystery. What becomes increasingly evident is that regulation of NS5A hyperphosphorylation plays an important role. We started to ... See full document
8
Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice.
... Thus, the early events of viral entry into the gastrointestinal tract can be summarized as a virusISVP-virus cycle in which the conversion of inoculated virus to ISVPs occurs in the lume[r] ... See full document
6
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