[PDF] Top 20 Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication
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Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication
... ⴙ 1 does not play a role in the HCV replication cycle in cell ...impaired RNA replication is due to the lack of core ⫹ 1 expression or to the alterations of stem- loop ... See full document
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Tomato Bushy Stunt Virus Genomic RNA Accumulation Is Regulated by Interdependent cis-Acting Elements within the Movement Protein Open Reading Frames
... lanes 1 to 4), restored ...of viral RNAs for pT/BtSc (⌬nt 4368 to 4404), pT/HSc (⌬nt 4172 to 4404), and pT/BgSc (⌬nt 4117 to 4404) was very low or below detectable levels ...lanes 1 to ...restored ... See full document
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EWSR1 Binds the Hepatitis C Virus cis-Acting Replication Element and Is Required for Efficient Viral Replication
... epatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis, and hepatocellular ...positive-strand RNA virus classified within the family Fla- viviridae. The viral ... See full document
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Systematic Analysis of Enhancer and Critical cis-Acting RNA Elements in the Protein-Encoding Region of the Hepatitis C Virus Genome
... for viral genome replication (57); however, a new study reported that this interaction was not critical for viral production of an intragenotype 2a chimeric virus, J6/JFH-1, in ... See full document
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Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... Hepatitis C virus (HCV) is an enveloped RNA virus con- taining a single-stranded, positive-sense RNA genome approx- imately ...The viral RNA genome is composed of a ... See full document
7
Interplay of RNA Elements in the Dengue Virus 5′ and 3′ Ends Required for Viral RNA Replication
... mediating translation of Renilla luciferase (Luciferase) reporter gene and the viral open reading frame (ORF) spanning the C-terminal sequence of E and NS1 to ...the viral ... See full document
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Sequence and Structural Elements at the 3′ Terminus of Bovine Viral Diarrhea Virus Genomic RNA: Functional Role during RNA Replication
... Bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus in the family Flaviviridae, has a positive-stranded RNA genome consisting of a single open reading frame and ... See full document
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3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)
... Hepatitis C virus (HCV) is a major cause of liver disease, with more than 130 million people currently chronically in- fected worldwide (46, ...genotype 1-infected ...The viral genome ... See full document
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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
... ) RNA will most likely interfere with IRES activity residing in the complementary sequences of the 5 ⬘ ...genotype 1 isolates hold true for the widely used genotype 2a isolate JFH1 that supports production ... See full document
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A Recombinant Hepatitis C Virus RNA-Dependent RNA Polymerase Capable of Copying the Full-Length Viral RNA
... Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus causing acute and chronic hepatitis in humans, frequently leading to liver cirrhosis and hepatocellular ... See full document
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cis- and trans-Acting Elements in Flavivirus RNA Replication
... of virus secretion noted above could be the inability of these RNAs with dele- tions in the helicase domain of NS3 to be packaged due to the absence of a putative packaging signal normally located (say) in the ... See full document
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Sigma-1 Receptor Regulates Early Steps of Viral RNA Replication at the Onset of Hepatitis C Virus Infection
... of viral replication, we set out to determine whether S1R and components of the viral repli- case colocalize during HCV ...D183 virus and incubated for 16, 48, and 72 h, after which the cells ... See full document
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Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication
... proviral role of ADAR1. This protein enhances viral replication, particularly for RNA viruses, by at least two mechanisms: RNA editing and PKR inhibition (15, ...immunodeficiency ... See full document
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A new cis-acting element for RNA replication within the 5' noncoding region of poliovirus type 1 RNA.
... poliovirus RNA contains signals important for virus-specific RNA replication and ...(nt 1 to 88) and the remaining structure (downstream of nt 120) are for viral RNA ... See full document
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Fine Mapping of a cis-Acting Sequence Element in Yellow Fever Virus RNA That Is Required for RNA Replication and Cyclization
... the RNA sequences essential for replication, we examined constructs C18, C15, and C14, and representative results for C15 and C14 are shown in ...were replication competent as evidenced by the ... See full document
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Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication
... HCV RNA synthesis, in which genome replication occurs within ER-derived vesicles of the membranous web whose formation is believed to be driven, at least in part, by the oligomerization of NS4B (10, 15, ... See full document
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DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... double-stranded RNA and separate the RNA strands or might contribute to the function of HCV NS3 ...the replication of subgenomic replicon RNA was also partially suppressed in DDX3 knockdown ... See full document
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Viral Evolution and Interferon Resistance of Hepatitis C Virus RNA Replication in a Cell Culture Model
... produced cell colonies only as a rare event, and an R2884G adaptive mutation produced cell colonies with com- paratively high efficiency (31). The L2198S mutation alone rendered only a slight improvement in transduction ... See full document
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Phosphorylation of Hepatitis C Virus RNA Polymerases Ser29 and Ser42 by Protein Kinase C-Related Kinase 2 Regulates Viral RNA Replication
... bind RNA (54), may require a conformational change of NS5B for its interaction with these cel- lular ...which viral and/or cel- lular proteins lose or acquire the ability to bind phosphorylated ...of ... See full document
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Identification of the cis-acting signal for minus-strand RNA synthesis of a murine coronavirus: implications for the role of minus-strand RNA in RNA replication and transcription.
... We further showed that the DI clones which actively transcribed a subgenomic mRNA from an internal intergenic sequence synthesized much less minus-strand RNA than those clones which did [r] ... See full document
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