[PDF] Top 20 Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx
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Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx
... of JMJD5 was crucial for HBV ...of JMJD5 with HBx facilitates HBV replication through the hydroxylase activity of ...IMPORTANCE HBx protein encoded by hepatitis B ... See full document
13
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation.
... 1994 Hepatitis B virus is a major risk factor in human hepatocellular ...17-kDa hepatitis B virus gene product, HBx, binds directly to the human tumor suppressor ... See full document
9
Inhibition of Cellular Proteasome Activities Mediates HBX-Independent Hepatitis B Virus Replication In Vivo
... HBV replication in vivo and that this effect is mediated by the function of ...tional interaction of HBX with the proteasome complex in cell culture ...HBV replication resides in a ... See full document
6
The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication
... As HBx has no known direct DNA binding property, therefore, it is not a typical ...mediated through protein-protein interaction with endogenous cellular proteins, transcription factors and cofactors, ... See full document
9
Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner
... of HBx that dramatically increased cccDNA levels and viral replication in an HBx- dependent ...stabilized HBx and pro- moted its rapid translocation to the nuclear and mitochondrial ...with ... See full document
25
The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... HBV replication at different steps of the viral life cycle in various ways ...HBV replication via binding the C-terminal of HBx and blocking HBx-mediated degradation of Smc5/6 that is ... See full document
10
Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA
... Coimmunoprecipitation analysis coupled with site-directed mutagenesis revealed that the region from amino acids 17 to 20 of the HBx, particularly HBx Cys 17 , is re- sponsible for the interaction ... See full document
18
HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function
... of HBx favors its chromatin localization and transcriptional reg- ulation ...of HBx affects the localization of HBx, we examined the subcellular localization of HBx and its ...WT HBx ... See full document
13
DDB1 Stimulates Viral Transcription of Hepatitis B Virus via HBx-Independent Mechanisms
... ABSTRACT HBx, a small regulatory protein of hepatitis B virus (HBV), augments viral DNA replication by stimulating viral ...reported HBx-binding proteins, DDB1 has drawn ... See full document
10
The Viral Oncoprotein HBx of Hepatitis B virus Promotes the Growth of Hepatocellular Carcinoma through Cooperating with the Cellular Oncoprotein RMP
... As HBx has been shown to cooperate with on- cogenes by upregulating their expression (13,14,17), we examined if HBx regulated the expression of en- dogenous oncogene RMP in HCC ...of HBx expression ... See full document
12
Activation and Inhibition of Cellular Calcium and Tyrosine Kinase Signaling Pathways Identify Targets of the HBx Protein Involved in Hepatitis B Virus Replication
... viral replication (3, ...whether HBx activa- tion of viral replication can be inhibited by herbimycin A or geldanamycin, which have demonstrated clinical activity in down-regulation of tyrosine ... See full document
7
Inhibition of hepatitis B virus (HBV) gene expression and replication by HBx gene silencing in a hydrodynamic injection mouse model with a new clone of HBV genotype B
... the HBx coding region has a stronger antiviral effect than that targeting the region nt 314– ...preference, interaction with the cellular machinery called RISC and so on are likely to contribute to ... See full document
15
The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival
... with hepatitis B virus (HBV) is a risk factor for developing liver diseases such as hepatocellular carcinoma ...(HCC). HBx is a multifunctional protein encoded by the HBV genome; ... See full document
14
Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1
... activation through interaction with Jab1 ...HBV replication mediated by ...HBV replication, which were totally different from HEK293 ...HBV replication remains to be further ... See full document
10
Involvement of Creatine Kinase B in Hepatitis C Virus Genome Replication through Interaction with the Viral NS4A Protein
... with hepatitis C virus (HCV) is a major cause of chronic liver ...cell factor(s) participating in the HCV replication complex (RC) and to clarify the regulatory mechanisms of viral genome ... See full document
11
The hepatitis E virus ORF3 protein regulates the expression of liver-specific genes by modulating localization of hepatocyte nuclear factor 4
... The hepatitis E virus (HEV) is a small RNA virus and the cause of acute viral hepatitis ...liver-enriched hepatocyte nuclear factor 4 (HNF4), which regulates ... See full document
10
Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... transcription factor on HBV transcription and replication observed in cell culture can be recapitulated in vivo in the HBV transgenic mouse model ...growth factor binding protein 1 gene ...viral ... See full document
7
Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... HNF6 accelerates the rates of decay of HBV RNA indepen- dent of La. As the HNF6-mediated HBV RNA reduction occurs posttranscriptionally, we suggest that HNF6 may promote the turnover rate of HBV pgRNA. To this end, we ... See full document
11
MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway
... ABSTRACT Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured ...miR-130a regulates HCV and hepatitis B ... See full document
15
MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway
... ABSTRACT Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured ...miR-130a regulates HCV and hepatitis B ... See full document
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