[PDF] Top 20 Hereditary deficiency of the second component of complement (C'2) in man
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Hereditary deficiency of the second component of complement (C'2) in man
... The hemolytic, bactericidal, and immune adherence activities of C'2 deficient serum were fully restored upon the addition of highly purified human C'2.5 These observations suggest that t[r] ... See full document
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Effect of C′1 esterase on vascular permeability in man: studies in normal and complement deficient individuals and in patients with hereditary angioneurotic edema
... specific hereditary deficiency of C¢2 is evidence for the complement-dependent nature of this ...intradermal C¢1 esterase developed by individuals with an acquired specific ... See full document
9
The molecular basis of hereditary complement factor I deficiency
... Family 2: investigation of ...a second smaller product ( z 475 bp), in similar quantity to the larger one, was generated from the proband’s RNA only ... See full document
10
Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man Reconstitution of normal C8 from the mixture of two abnormal C8 molecules
... component of complement (C8)-deficient subjects. The sera fell into two groups, depending on whether hemolytic activity was restored by the addition of the beta-chain (group 1) or the alpha-gamma-subunit ... See full document
10
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
... classical complement pathway in glau- coma ...the complement cascade in general in glaucoma ...a second key component of the complement cascade, C5, modulates the progression of RGC ... See full document
8
The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement
... C2 deficiency were ...C2 deficiency gene and the HLA-B gene, with a recombinant fraction of ...C2 deficiency and HLA-B at a maximum likelihood value of the recombinant fraction of ... See full document
10
Invasive meningococcal disease in three siblings with hereditary deficiency of the 8th component of complement: evidence for the importance of an early diagnosis
... lectin complement pathways was measured in serum from the 3 siblings and their parents (37-year-old woman and 42-year-old ...Serum complement factors were measured by haemolytic assays and ...three ... See full document
6
Hereditary deficiency of the sixth component of complement in man II Studies of hemostasis
... sixth component of complement (C6), an evaluation was made of the hemostatic functions of the homozygous proband of a newly recognized human kindred with hereditary C6 ... See full document
6
Inherited deficiency of the second component of complement Rheumatic disease associations
... heterozygous deficiency of the second component of complement (C2) was determined in patients with rheumatic disease including 137 with systemic lupus erythematosus (SLE), 274 with juvenile ... See full document
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Hereditary deficiency of the fifth component of complement in man II Biological properties of C5 deficient human serum
... several biological properties of C5-deficient (C5D) human serum, particularly sera obtained from two C5D homozygotes. The proband, who has inactive systemic lupus erythematosus is completely lacking C5, while her healthy ... See full document
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Hereditary deficiency of the sixth component of complement in man I Immunochemical, biologic, and family studies
... other complement components were ...C6 deficiency, while the proband is homozygous and one sibling is ...C6 deficiency appears to follow classic mendelian inheritance, with all three possible ... See full document
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Hereditary deficiency of the fifth component of complement in man I Clinical, immunochemical, and family studies
... with hereditary deficiency of the fifth component of complement (C5) is ...hemolytic complement activity, even during ...Other complement components were normal during remission ... See full document
10
Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization
... with serum for 20 minutes + 20 mM EDTA served as nega- tive control for C activation. Subsequently, PS-NPs were pelleted by centrifugation (5,000 g for 6 minutes at 4 ° C), followed by washing twice in ... See full document
13
Management of Hereditary Angioedema in Pediatric Patients
... comprehensive care clinics are capable of meeting edu- cational, research, and development requirements in ad- dition to delivering state-of-the-art patient care (Table 2). International cooperation between ... See full document
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Microglia in Alzheimer’s disease
... Under physiological conditions, microglia retain a neural-specific phenotype (82) and remain in a relatively quiescent state due to mutual exchange of neuronal and astrocytic signals (83, 84). Neuron- microglial ... See full document
11
Fixation of the first component of complement (C′1a) by human antibodies
... Antibodies of the Rh system do not fix significant amounts of C¢1a in the absence of anti- antibody when antiserum of a single Rh specificity was used. However, when three antisera at different specificity are ... See full document
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Genetic polymorphism of the third component of human complement (C′3)
... The allotypes appear to differ in net surface charge at pH 8.6, but show no obvious differences in complement activity, in molecular size, or in binding of Ca ++ . The concentrations of the two gene products in ... See full document
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Synthesis of C1 inhibitor in fibroblasts from patients with type I and type II hereditary angioneurotic edema
... with hereditary angioneurotic edema (HANE) have serum levels of functionally active inhibitor of the first component of complement (C1 INH) between 5 and 30% of normal, instead of the 50% expected ... See full document
Molecular basis of complement C3 deficiency in guinea pigs
... determined deficiency of the third component of complement (C3) in guinea pigs, we found that C3-deficient liver and peritoneal macrophages contain C3 messenger RNA of normal size (approximately 5 ... See full document
12
Monocyte surface expression of Fcγ receptor RI (CD64), a biomarker reflecting type I interferon levels in systemic lupus erythematosus
... tamine, 100 IU/ml penicillin, and 100 μg/ml streptomycin. Cytokines were from BD Bioscience, unless otherwise indicated. Cells were incubated for 19 hours at 37°C in medium containing 25% serum from either SLE ... See full document
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