[PDF] Top 20 The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection.
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The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection.
... Because the majority of herpes simplex virus type 1 HSV-1 transcripts are not spliced 60, whereas the majority of cellular transcripts are spliced, we have considered the possibility tha[r] ... See full document
14
Association of Herpes Simplex Virus Type 1 ICP8 and ICP27 Proteins with Cellular RNA Polymerase II Holoenzyme
... its protein components, the cellular Pol II holoenzyme is a large, multisubunit complex composed of the core Pol II, general transcription factors such as TFIIB, TFIIE, TFIIF, and TFIIH but not TBP and its ... See full document
12
Head to Tail Intramolecular Interaction of Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Important for Its Interaction with Cellular mRNA Export Receptor TAP/NXF1
... of ICP27, encompassing the leucine-rich region, the nuclear localization signal, the RGG box RNA binding domain and binding sites for TAP/NXF1 (3), Hsc70 (5), RNA polymerase II (12), RNA export factors Aly and Ref ... See full document
9
PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0
... HSV-1 infection (6, 23), and the replication of neither wild-type (wt) nor ICP0-negative HSV-1 viruses is improved in mouse PML ⫺/⫺ fibroblasts ...single protein but rather a family of related isoforms that ... See full document
11
The Conserved Carboxyl-Terminal Half of Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Dispensable for Viral Growth in the Presence of Compensatory Mutations
... lytic infection, amplifying viral genomes for later packaging into progeny ...(13). ICP27 has an important role in activating viral DNA replication, as it stimulates the levels of replicated DNA by ... See full document
13
Herpes Simplex Virus 1 Regulatory Protein ICP27 Undergoes a Head-to-Tail Intramolecular Interaction
... Some cellular proteins have been shown to fold into a head-to-tail conformation that can inhibit interactions with ligands or other proteins (7, 11, 22, 27, 28, 28, 44, ...scaffold protein PDZK1 undergoes a ... See full document
12
The Interaction of the Cellular Export Adaptor Protein Aly/REF with ICP27 Contributes to the Efficiency of Herpes Simplex Virus 1 mRNA Export
... multifunctional protein that plays a number of impor- tant roles during HSV-1 ...viral mRNA export, a task that ICP27 accomplishes by binding viral RNA (22–24, 39) and interacting with ... See full document
8
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1
... infections. ICP27 from herpes simplex virus is a multifunctional regulatory protein that is functionally conserved in all known human ...of cellular proteins, as well as ... See full document
12
Arginine Methylation of the RGG Box Does Not Appear To Regulate ICP27 Import during Herpes Simplex Virus Infection
... multifunctional regulatory protein that shuttles between the nucleus and cytoplasm in herpes simplex virus 1 (HSV-1)-infected ...cells. ICP27 interacts with a number of cel- ... See full document
5
Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... VP16 mRNA is greatly decreased in cells infected with viruses lacking ...how ICP27 modulates VP16 gene expres- sion, we undertook a series of experiments that carefully com- pared the levels of VP16 ... See full document
12
Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.
... which ICP27 carries out its lytic functions have not yet been ...that ICP27 may work, at least in part, through posttranscriptional gene regulatory ...which ICP27 can either activate or ... See full document
13
The Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Required for the Prevention of Apoptosis in Infected Human Cells
... Herpes simplex virus type 1 (HSV-1) is a neurotropic her- pesvirus which causes a variety of infections in ...the virus after reactivation from the latent state. During a productive ... See full document
11
Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.
... Infected-cell protein 4 (ICP4) is the major transcriptional activator of herpes simplex virus (HSV) gene expression during productive ...as cellular genes and genes of ... See full document
11
Identification of a Motif in the C Terminus of Herpes Simplex Virus Regulatory Protein ICP4 That Contributes to Activation of Transcription
... productive infection for the viral mutants were then compared in Vero cells infected at a low multiplicity ...similar levels (based on immunoblot analysis with anti-EGFP [data not shown]) and localized to ... See full document
13
Herpes Simplex Virus ICP27 Is Required for Virus-Induced Stabilization of the ARE-Containing IEX-1 mRNA Encoded by the Human IER3 Gene
... IEX-1 mRNA appears to be stabilized by the stresses associated with the transfection protocol (data not ...that ICP27 is directly responsible for the altered turnover of ...the ICP27 mutants d1-2, ... See full document
10
Modification and Reorganization of the Cytoprotective Cellular Chaperone Hsp27 during Herpes Simplex Virus Type 1 Infection
... points during the course of ...the virus. It is also possible that Hsp27 mod- ification during HSV-1 infection is related to a newly described role for the protein in ARE (AU-rich RNA ... See full document
9
Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.
... after infection with HSV, host cell protein synthesis is shut off (7, ...virion-associated protein and the expression of ICP27 (10, 12, 27, ...off cellular protein synthesis at ... See full document
10
Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants
... functional mRNA molecules in the ...that ICP27 can activate or repress the expression of reporter genes driven by HSV promoters in transient cotransfection assays (17, 30, 41, 42, 45, 53, ...that ... See full document
13
The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction.
... by protein phosphorylation ...70-kDa protein and the 85-kDa protein may be significant in the effect of ICP27 on splicing and the reassortment of ...the levels of phosphorylation of ... See full document
11
Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.
... HSV ICP27 protein in transient CAT ...of ICP27 have proved to directly up-regulate expression of standard CAT reporter cassettes (40, 44, 63, 67), but with the EBV and HSV versions this occurred in a ... See full document
9
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