[PDF] Top 20 Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.
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Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.
... 2339 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Herpes simplex virus HSV virions contain at least two regulatory proteins that modulate gene expression in infected [r] ... See full document
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Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.
... The herpes simplex virus transactivator VP16 and the virion host shutoff protein vhs are viral structural components that direct the activation of ... See full document
8
Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State
... Herpes simplex virus type (HSV) is a ubiquitous human pathogen responsible for a variety of conditions, including cold sores, genital sores, and keratitis in immunocompetent ...the virion ... See full document
9
Selective Ablation of Virion Host Shutoff Protein RNase Activity Attenuates Herpes Simplex Virus 2 in Mice
... Western blot analysis. Cell lysates were prepared by mock infecting or infect- ing Vero cells at a multiplicity of infection (MOI) of 5 with either the 333 (wild-type), 333d41 (vhs ⫺ deletion mutant), D215N ... See full document
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Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated Immunotherapy
... and vhs deleted allow the stimulation of antigen-specific T-cell ...which vhs is also removed might be used as vectors for DC due to their ability to infect DC at high efficiency and because the ... See full document
9
Herpes Simplex Virus 1 Counteracts Tetherin Restriction via Its Virion Host Shutoff Activity
... cell-associated virus titers ...leased virus titers ...relative virus release as a percentage of total infectivity demonstrated a significant ...as VP16 or on the expression of VP1/2 from the ... See full document
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The Herpes Simplex Virus 1 Virion Host Shutoff Protein Enhances Translation of Viral Late mRNAs by Preventing mRNA Overload
... the vhs-deficient virus ...of vhs does not stem from one or more structural features of the affected mRNAs but instead arises be- cause these transcripts accumulate late during ... See full document
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mRNA Decay during Herpes Simplex Virus (HSV) Infections: Mutations That Affect Translation of an mRNA Influence the Sites at Which It Is Cleaved by the HSV Virion Host Shutoff (Vhs) Protein
... which Vhs is directed to its preferred cut sites, in this study we examined in vitro degra- dation of target mRNAs in rabbit reticulocyte lysates containing in vitro-translated ...Vhs. Vhs caused ... See full document
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The Effect of Herpes Simplex Virus Virion Host Shutoff Gene- a New Suicide Gene- on Tumor Cells
... HSV-2 Vhs is 40 folds stronger than that of HSV-1 [7]. Vhs acts as an RNase either alone or in conjunction with eukaryotic translation initiation factor 4H [2, 8, ...The Vhs preferentially initiates ... See full document
5
Herpes Simplex Virus Virion Host Shutoff Protein Requires a Mammalian Factor for Efficient In Vitro Endoribonuclease Activity
... that vhs is an integral component of the vhs-dependent endoribonuclease but leave open the possibility that one or more mammalian subunits or cofactors are required for its ...expressing vhs in the ... See full document
14
mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease
... that Vhs induces mRNA turnover, a central unanswered question is whether Vhs is itself an RNase or, instead, activates a cellular ...onstrated Vhs-dependent cleavage of target mRNAs in cyto- plasmic ... See full document
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The Virion Host Shutoff Protein (UL41) of Herpes Simplex Virus 1 Is an Endoribonuclease with a Substrate Specificity Similar to That of RNase A
... GST-vhs protein preferentially cleaves ss C residues over ss U residues, five additional oligo- nucleotides, RNA 4 to RNA 8, were ...more complex than those of the last oligonucleotides tested (RNA 4 ... See full document
5
Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase
... wild-type virus was highly selective (14, 16, ...with VHS protein (15), and (iii) in uninfected cells, TTP binds AREs and sequesters the mRNAs for degradation by exo- somes (5, ... See full document
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The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation
... vaccinia virus-infected cells ...with vhs- deficient HSV-1, a nuclear DNA ...more complex, at least in cells infected with an HSV-1 vhs ...during vhs mutant infection, titrating one or ... See full document
9
mRNA Decay during Herpes Simplex Virus (HSV) Infections: Protein-Protein Interactions Involving the HSV Virion Host Shutoff Protein and Translation Factors eIF4H and eIF4A
... formed with a DNA cocktail containing pACT2-Vhs, the large SacII-BamHI fragment of pAS2-4H, and a SalI-linearized pGEX-eIF4H plasmid containing a mutant eIF4H allele. The large SacII-BamHI fragment of pAS2-4H ... See full document
14
The Herpes Simplex Virus 2 Virion-Associated Ribonuclease vhs Interferes with Stress Granule Formation
... that vhs is an endoribonuclease whose activity in vivo is directed toward cellular and viral mRNAs (24, 25, ...of vhs into the tegument of virions allows this endoribonuclease to be delivered to the ... See full document
13
Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41
... in host antiviral responses, it is reasonable to presume that DNA viruses should evolve certain mechanisms to block this signal ...US3, VP16, and UL42, which have previously been proved to inhibit IFN ... See full document
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The vhs1 Mutant Form of Herpes Simplex Virus Virion Host Shutoff Protein Retains Significant Internal Ribosome Entry Site-Directed RNA Cleavage Activity
... mutant vhs on SRP␣ RNA, a transcript that lacks an IRES ...wild-type vhs (Fig. 3B). In contrast, reactions containing the vhs1 mutant protein did not display readily detectable quantities of these ... See full document
5
Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein
... by vhs (59, ...that vhs is recruited to mRNAs through interactions with translation initiation factors predicts that the 5⬘ cap should markedly stimulate degradation of mRNAs that lack an ...contain ... See full document
10
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1
... mutant virus, we employed a cell line expressing a constitutively active form of MEK (caMEK), designated ...⌬ VHS mutant viruses showed impaired replication in HT92-6 cells compared to replication in the ... See full document
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