[PDF] Top 20 The Herpes Simplex Virus 1 UL51 Gene Product Has Cell Type-Specific Functions in Cell-to-Cell Spread
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The Herpes Simplex Virus 1 UL51 Gene Product Has Cell Type-Specific Functions in Cell-to-Cell Spread
... mutant spread phenotypes cannot be accounted for by defects in gE ...in UL51 on CCS could never be larger than that of a deletion of ...acids 1 to 335 of gE were deleted and compared their ... See full document
11
Requirement of Interaction of Nectin-1α/HveC with Afadin for Efficient Cell-Cell Spread of Herpes Simplex Virus Type 1
... nectin- 1␣-⌬C-L, and L cells. The gD-binding activities of nectin-1␣-L cells and nectin-1␣-⌬C-L cells were similar but remarkably higher than that of L cells ...It has recently been shown that ... See full document
10
The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread
... Herpes simplex virus (HSV) expresses a number of membrane glycoproteins, including gB, gD, and gH/gL, that function in both entry of virus particles and movement of virus from an ... See full document
10
The Herpes Simplex Virus gE-gI Complex Facilitates Cell-to-Cell Spread and Binds to Components of Cell Junctions
... epithelial cell junctions in the absence of other HSV polypeptides provides important clues as to how gE-gI facilitates epithelial cell-to-cell ...gE-gI functions, based on the present ... See full document
10
Herpes Simplex Virus gE/gI Expressed in Epithelial Cells Interferes with Cell-to-Cell Spread
... gE gene was inserted into a shuttle vector, pAdtet7, which contains loxP sites; a basal HCMV promoter that is regulated by a tetracycline transac- tivator protein; and flanking Ad sequences (9, ...Ad type 5 ... See full document
10
Transcriptional targeting of herpes simplex virus for cell-specific replication.
... or cell-specific targeting of vectors is critical to the success of gene ...to virus-mediated gene therapy, where viral replication and associated cytotoxicity are limited to a ... See full document
9
The equine herpesvirus 1 glycoprotein gp21/22a, the herpes simplex virus type 1 gM homolog, is involved in virus penetration and cell-to-cell spread of virions.
... a cell line which expresses EHV-1 gM and complements its ...viral spread in cultured cells. HSV-1 gM has similarly been implicated in cell-to-cell fusion, which may ... See full document
6
Cell Type-Specific Induction and Inhibition of Apoptosis by Herpes Simplex Virus Type 2 ICP10
... the specific cell ...(UL39) gene expression leads to the same initial signaling event in all cell types, yet results in different apoptotic outcomes due to differences in the subsequent ... See full document
5
Herpes Simplex Virus 1 pUL34 Plays a Critical Role in Cell-to-Cell Spread of Virus in Addition to Its Role in Virus Replication
... alternative spread path- way depends on the effect of the R58Stop ...phenotype has been previously found by Negatsch and colleagues in the supposedly wild-type strain HSV-1 KOS ...alternative ... See full document
13
Mutations in Herpes Simplex Virus Glycoprotein D Distinguish Entry of Free Virus from Cell-Cell Spread
... gD gene were amplified from genome-length viral DNA of wild- type and mutant viruses using the Advantage-HF 2 PCR kit (Clontech) and primers gDflankL (5⬘-GTGATGTCGGGTCCAAACTC-3⬘) plus gDflankR (5⬘- ...PCR ... See full document
10
Responses of Herpes Simplex Virus Type 1-Infected Cells to the Presence of Extracellular Antibodies: gE-Dependent Glycoprotein Capping and Enhancement in Cell-to-Cell Spread
... itself has a much less potent plaque-inhibitory effect at lower concentra- ...in cell- to-cell spread might involve a coclustering of multiple glyco- proteins, as observed in the capping ... See full document
8
Cell-Type-Specific Tyrosine Phosphorylation of the Herpes Simplex Virus Tegument Protein VP11/12 Encoded by Gene UL46
... by gene UL46. Tyrosine phosphorylation of VP 11/12 was lymphocyte specific, and in Jurkat cells it required the Src family kinase Lck, a key player in the activation pathways of both T and NK ...NK ... See full document
11
Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
... increase virus infection of cells low in adeno- virus receptor density ...and has the sequence ...mutant gene revealed a molecular size consistent with the predicted ...the cell surface ... See full document
12
Novel Mutations in gB and gH Circumvent the Requirement for Known gD Receptors in Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread
... enhance virus entry into cells that lack canonical gD ...for virus growth in the ab- sence of known functional gD receptors, we transferred these mu- tations into a wild-type virus background; ... See full document
13
Contribution of Endocytic Motifs in the Cytoplasmic Tail of Herpes Simplex Virus Type 1 Glycoprotein B to Virus Replication and Cell-Cell Fusion
... the cell membrane was ...to virus infection, we con- structed recombinant viruses containing either gBY889A or gBLL871AA in place of gB, using classical cotransfection pro- ...this virus derived from ... See full document
15
The Extracellular Domain of Herpes Simplex Virus gE Is Indispensable for Efficient Cell-to-Cell Spread: Evidence for gE/gI Receptors
... of cell-free virus, gE/gI receptors may be more exclusively local- ized to cell ...apical cell surfaces in order to mediate HSV entry into epithelial ...for cell-to-cell ... See full document
12
Polarized Cell Migration during Cell-to-Cell Transmission of Herpes Simplex Virus in Human Skin Keratinocytes
... Simplex Virus in Human Skin Keratinocytes Fernando Abaitua, ...of virus propagation is one wherein virus replicates in one cell, producing infectious particles that transmit to the next ... See full document
12
Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity
... in UL51, serine 184 (Ser-184), but not the other identified phosphorylation sites, significantly re- duced viral replication and cell-cell spread in HaCaT ...in UL51 Ser-184 significantly ... See full document
21
Conservation of Type Specific B Cell Epitopes of Glycoprotein G in Clinical Herpes Simplex Virus Type 2 Isolates
... Except for two clinical HSV-2 isolates which harbored iden- tical, single missense mutations at the very end of the carboxy terminus of the immunodominant region, the three epitope regions were conserved among the ... See full document
6
Herpes Simplex Virus gE/gI Must Accumulate in the trans-Golgi Network at Early Times and Then Redistribute to Cell Junctions To Promote Cell-Cell Spread
... facilitates cell-to-cell ...into specific subdomains of the TGN that then sort nascent virions to cell ...apparently functions at some post-TGN site and must move to cell ... See full document
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