[PDF] Top 20 Host Factors in Enterovirus 71 Replication
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Host Factors in Enterovirus 71 Replication
... the replication complex probably through a direct and specific interaction with the EV71 2C ...viral replication of EV71 and possibly other ...the replication of many enteroviruses ... See full document
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Human MicroRNA hsa-miR-296-5p Suppresses Enterovirus 71 Replication by Targeting the Viral Genome
... Enterovirus 71 (EV71) is a member of the Picornaviridae family and belongs to the genus Enterovirus (human enterovirus ...in host cells (28), which are likely to play a role in the ... See full document
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Cell Surface Vimentin Is an Attachment Receptor for Enterovirus 71
... the replication of EV71 in VK-U251 cells was also re- FIG 6 Effect of pretreating host cells with vimentin antibodies on the binding of EV71 to the ...BrCr replication in U251 cells that had been ... See full document
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hnRNP A1 Interacts with the 5′ Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication
... the host cell, the ge- nome RNA is translated into two polyproteins, P123 and P1234; these are processed by a viral protease, giving rise first to several intermediate cleavage products and then to the four viral ... See full document
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Strategies to develop antivirals against enterovirus 71
... The VP1 protein of poliovirus or rhinovirus has also been shown to form a canyon structure, which is important for receptor binding. In addition, conformational change of the VP1 protein is the crucial step for viral ... See full document
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Differential expression of miRNAs in enterovirus 71 infected cells
... the host response to EV71 infection and to elucidate the pathogenesis mechanism of EV71 virus, miRNAs profiles in the EV71-infected cells were examined in this ... See full document
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Predicting Intraserotypic Recombination in Enterovirus 71
... model enterovirus is poliovirus (PV), the causative agent of poliomyelitis, a condition characterized by acute flaccid ...virus, enterovirus 71 (EV-A71), causes similar clinical outcomes in recurrent ... See full document
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MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells
... of host defense. They initiate specific host immune responses by capturing, process- ing, and presenting antigens through MHC-I and MHC- II molecules on the cellular surface and activating naïve T cells ... See full document
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Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein
... Identification of RAN GTPase as one of the miR-197 target genes in RD cells using MS-based SILAC and 3= UTR reporter assays. We speculated that the downregulation of EV71-induced miRNA expression might, in turn, increase ... See full document
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Cell and tissue tropism of enterovirus 71 and other enteroviruses infections
... Enterovirus 71 (EV71) is a member of Picornaviridae that causes mild and self-limiting hand, foot, and mouth disease ...neurotropic enterovirus for which there is currently no effective antiviral ... See full document
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Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry
... Knockout of FN reduces EV71 binding affinity to host cells. The observation that FN upregulates EV71 proliferation prompted us to further investigate the viral life cycle stage at which FN is involved. We ... See full document
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Recent developments in antiviral agents against enterovirus 71 infection
... high replication and mutation rates of enteroviruses may generate resistance to these direct- acting ...Targeting host factors may establish a higher genetic barrier to resistance and can be used in ... See full document
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Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells
... According to current and our previous studies, rhabdo- myosarcoma (RD) cells and the Henrietta Lacks strain of cancer (HeLa) cells can be used as in vitro models to investigate the interplay between EV71 and its ... See full document
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Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
... infect host cells, needing toutilizemany functional components of different cellular signaling pathways in ...EV71 replication in embryonic rhabdomyosarcoma (RD) cells [4, 5], human embryonic kidney (HEK) ... See full document
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Inhibition of enterovirus 71 replication and viral 3C protease by quercetin
... EV71 replication through a novel mechanism by targeting trans-acting factors ...EV71 replication by inhibition of the activity of the virus-encoded 3C pro , and the results verified that flavo- noids ... See full document
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SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication
... with enterovirus 71 (EV71) often causes neurological diseases in children, and EV71 is responsible for the majority of ...and host cell, antiviral drugs against enteroviruses may be ...virus ... See full document
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Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model
... with host membrane vesicles, which form viral replication complexes where viral RNA synthesis takes place ...a replication complex with RNA on the ...the host cytoplasm early after infection ... See full document
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Formononetin inhibits enterovirus 71 replication by regulating COX 2/PGE2 expression
... Overall, our findings provide a new clue for developing the anti-EV71 drug which acts on inhibition of both viral replication and inflammatory factors expression. This may offer hopes in the treatment of ... See full document
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Enterovirus 71 Infection Induces Apoptosis in Vero Cells
... doubt that apoptosis noted were caused by HEV71 infection. Nonetheless, it was argued that perhaps the inability to detect HEV71 positive cells in the patients’ tissues was due to the induction of apoptosis that ... See full document
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HLA-A33 Is Associated With Susceptibility to Enterovirus 71 Infection
... 219 enterovirus 71 cases, 26% (56 of 219 cases) were uncomplicated cases, 74% (163 of 219 cases) were complicated cases, 57% (125 of 219 cases) were complicated cases with central nervous system ... See full document
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