[PDF] Top 20 Human T cell leukemia virus type I Tax induces the expression of CD83 on T cells
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Human T cell leukemia virus type I Tax induces the expression of CD83 on T cells
... that CD83 was expressed selectively on Tax1-expressing human CD4 + T cells in short-term cultured peripheral blood mononuclear cells (PBMCs) isolated from HTLV-I + donors, ... See full document
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Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene
... synovial cell proliferation with bone ...synovial cell proliferation remain to be ...that human T cell leukemia virus type I (HTLV-I) may play an ... See full document
9
Role of Tax protein in human T cell leukemia virus type I leukemogenicity
... render Tax highly oncogenic as reflected by its ability to transform rodent fibroblasts and primary human T-cells and to induce tumors in transgenic ...of Tax and their apparent ... See full document
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Human T cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
... p40 expression [43]. Because the expression of genes that were induced in A549 cells cocul- tured with MT-2 cells was regulated by only NF-κB and AP-1, and Tax protein increases ... See full document
10
Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression.
... The X region of human T-cell leukemia virus type I (HTLV-I) encodes two proteins that regulate viral gene expression.. The tax protein is the product of the transactivator gene and has b[r] ... See full document
10
Molecular biology of the type I human T cell leukemia virus (HTLV I) and adult T cell leukemia
... The central role of these genes in normal T-cell activation and growth suggests that Tax activation of these cellular transcription units may represent an important mechanism by which HT[r] ... See full document
7
Human T-cell leukemia virus type I trans activator induces class I major histocompatibility complex antigen expression in glial cells.
... In this study, we demonstrated that the tax protein of HTLV-I can induce the expression of class I MHC antigens on glial cells (Fig. 1) by affecting the promoter of class I MHC genes (Fi[r] ... See full document
5
Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells
... gene expression may be ...HTLV-1 tax expression suggests that these stimuli may alter HTLV-1 pathogenesis in ...infected cells, possibly reflecting the effects of variable levels of ... See full document
7
Human T cell leukemia virus type 2 Tax protein induces interleukin 2 independent growth in a T cell line
... mouse T-cell line from an IL-2-dependent growth into an independent ...in T-cells, thus suggesting that this growth promoting activity of Tax2 contributes to HTLV-2-medi- ated ... See full document
7
Human T cell leukemia virus type I (HTLV I) infection and the onset of adult T cell leukemia (ATL)
... the virus replication due to nonsense muta- tions or impairment of viral gene functions, some become capable of replicating under different circumstances such as the presence of anti-HIV drugs and activation of ... See full document
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Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.
... Evidence for phosphorylation of trans-activator p4Ox of human T-cell leukemia virus type I produced in insect cells with a baculovirus expression vector. HTLV-1 associated myelopathy, a [r] ... See full document
6
The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein.
... Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40O"' protein in the human T-cell line, Jurkat. Detection and isolation of typ[r] ... See full document
6
Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells.
... unstimulated cells, NF- k B activity is regulated, in part, by posttranslational mech- ...termed I k B, that are respon- sible for cytoplasmic retention of NF- k B. I k B also constitutes a family of ... See full document
6
Expression and characterization of the trans-activating protein Tax of human T-cell leukemia virus type I in Saccharomyces cerevisiae.
... A high-copy-number plasmid bearing the tax gene under the control of the yeast alcohol dehydrogenase 1 promoter (2) transformed yeast cells but failed to show the 40-kDa Tax protein upon[r] ... See full document
9
Two discrete events, human T cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T cells
... the cell such as to pro- voke demise. Our findings suggest that Tax cannot singu- larly induce apoptosis efficiently in a T-cell ...for Tax to cause apop- tosis in a Jurkat ... See full document
12
Mutational analysis of human T-cell leukemia virus type 2 Tax.
... of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was performed to identify regions within Tax-2 important for activation of promoters through the ... See full document
6
Highly Enhanced Expression of CD70 on Human T-Lymphotropic Virus Type 1-Carrying T-Cell Lines and Adult T-Cell Leukemia Cells
... 2008 Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia ...the cell surface molecules that will become suitable targets of ... See full document
10
Costimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activator Tax.
... of Tax in cytokine gene expression is to costimulate high levels of tran- scription in cooperation with T-cell receptor ...HTLV-1-infected T cells, possibly as a result of ... See full document
8
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... by Tax, may possibly converge, creating a unique set of circum- stances required for T-lymphocyte transformation by ...D Tax do not eliminate the possibility that other viral gene products assist in ... See full document
9
Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene.
... vimentin promoter linked to the chloramphenicol acetyltransferase gene were transfected in HeLa cells and in two cell lines of hematopoietic origin (Jurkat T lymphoblastoid cells and U93[r] ... See full document
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