[PDF] Top 20 Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
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Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... of CD4 (9, 25, 39, 41, 42, 44, ...within Nef, situated at both the amino and carboxy termini of this viral regulatory ...of Nef have been proposed to interact with the cytoplasmic tail of ... See full document
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Maintenance of Nef-Mediated Modulation of Major Histocompatibility Complex Class I and CD4 after Sexual Transmission of Human Immunodeficiency Virus Type 1
... The human immunode- ficiency virus type 1 Nef protein performs several functions potentially important for successful infection, including immune escape via down-regulation of class I ... See full document
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Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain
... Human immunodeficiency virus type 1 (HIV-1) Nef is a protein containing roughly 200 amino acid ...of viral gene expression (13) and is a component of viral ... See full document
5
Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP
... the Nef-induced pertur- bations of membrane trafficking was further analyzed using chimeras in which the wt or mutated Nef was fused to the extracellular and transmembrane domains of the CD8 ␣ ...of ... See full document
6
Predicting the Impact of Blocking Human Immunodeficiency Virus Type 1 Nef In Vivo
... Human immunodeficiency virus type 1 (HIV-1) Nef is a multifunctional protein that confers an ability to evade killing by cytotoxic T lymphocytes (CTLs) as well as other ... See full document
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Association of Nef with the Human Immunodeficiency Virus Type 1 Core
... protein Nef is essential for efficient replica- tion and pathogenesis of primate ...the nef open reading frame results in attenuation of simian immunodeficiency virus in rhesus ... See full document
7
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
... of nef on the immunogenicity and pathoge- nicity of HIV-1 infection suggests that this gene could be a target for enhancing cellular immunity in chronically infected individuals or the design of ... See full document
6
CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... mary nef alleles were inserted into the respective vectors as a pool to ensure that they were representative for each time point ...(4). nef alleles derived from the 1989 and 1998 samples did not ... See full document
5
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
... Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is ...causes ... See full document
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Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity
... of Nef is required for enhance- ment of ...respective virus to replicate in nonprestimulated primary ...that viral phenotypes in single-cycle replication assays correspond to growth in primary ... See full document
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Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo
... The Nef protein of simian and human immunodeficiency virus (SIV and HIV) is an important determinant of AIDS pathogenesis (12, 20, ...SIV Nef interact with cell signaling and ... See full document
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Nef-Induced CD4 Endocytosis in Human Immunodeficiency Virus Type 1 Host Cells: Role of p56lck Kinase
... proper virus process- ing and assembly, the genomes of primate lentiviruses such as human immunodeficiency virus type 1 (HIV-1) encode auxil- iary proteins that modulate ... See full document
12
Functional Characterization of the Human Immunodeficiency Virus Type 1 Nef Acidic Domain
... the enhancement of infectivity but not CD4 down- ...MHC-I downregulation in both the NPA and NMA models. A crucial Nef residue that has not been included in either the NPA or NMA model is ... See full document
12
Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.
... for Nef-mediated downregulation of cell surface CD4, transfection mixtures con- taining ...wild-type human CD4 expression plasmid pcCD4, and increasing amounts of one of ... See full document
7
Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef
... The human immunodeficiency virus type 1 (HIV-1) early gene nef is highly polymorphic (10, 25, 30, 38, ...the Nef gene product alters numerous pathways of T-cell ... See full document
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Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... of Nef to enhance the infec- tivity of HIV-1 virions produced either in CD4-negative ad- herent cells or in a T-cell ...that Nef targets HIV-1 budding to lipid rafts in transiently ... See full document
6
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism
... of human and simian immodeficiency viruses (HIV and SIV, respec- tively) (15, 25, ...27). Nef increases viral spread both indirectly by mechanisms of immune evasion and directly by enhancing ... See full document
5
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... The Nef protein of human immunodeficiency virus type 1 (HIV-1) stimulates viral ...disrupted nef genes were 4 to 40 times less infectious than ... See full document
9
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... While Nef is packaged nonspecifically and at relatively low levels compared to those of Vpr, its presence in HIV-1 virions may nevertheless be biologically ...that Nef associates with cellular ... See full document
6
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... of Nef, cell surface CD4 molecules are actively endocytosed, accumulate into early endosomes, and are degraded, while CD4 synthesis is not ...The enhancement of endocytosis was observed both ... See full document
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