[PDF] Top 20 Human Immunodeficiency Virus Type 1 Virion Density Is Not Determined by Nucleocapsid Basic Residues
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Human Immunodeficiency Virus Type 1 Virion Density Is Not Determined by Nucleocapsid Basic Residues
... on virion density, replacement of HIV-1 NC basic residues with alanine dramatically impairs Gag-Gag interaction, as indicated by virion assembly defects and by failure of the ... See full document
7
Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity.
... Lack of nonspecific RNA incorporation by NC mutants. Previous reports indicate that mutations in NC that reduce genomic RNA incorporation lead to increased incorporation of spliced viral mRNAs (7, 15, 33). For this ... See full document
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Elimination of Protease Activity Restores Efficient Virion Production to a Human Immunodeficiency Virus Type 1 Nucleocapsid Deletion Mutant
... To examine the DelNC virions further, we added them to a microscale reversed-phase HPLC column to separate and iso- late the different proteins in the virions (Fig. 3A). The analysis detected all of the major mature Gag ... See full document
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Association of Human Immunodeficiency Virus Type 1 Gag with Membrane Does Not Require Highly Basic Sequences in the Nucleocapsid: Use of a Novel Gag Multimerization Assay
... The density of Gag-containing DRM has been observed to be higher than that of typical raft membranes in flotation gradients (20, 51), presumably due to the association of tightly packed Gag molecules with a ... See full document
10
Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion Encapsidation
... three residues may constitute the core of a site required for the Vif interaction, we constructed additional mutant proteins in which the chemical natures of the three side chains were ...charged, basic, ... See full document
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Redundant Roles for Nucleocapsid and Matrix RNA-Binding Sequences in Human Immunodeficiency Virus Type 1 Assembly
... the virion. While the nucleocapsid (NC) domain is the most conspicuous RNA-binding region of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein, we ... See full document
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Context-Dependent Phenotype of a Human Immunodeficiency Virus Type 1 Nucleocapsid Mutation
... Retroviral nucleocapsid (NC) carries out important func- tions throughout the entire retroviral life cycle (2, ...and virion assembly and directs the packaging of two copies of viral genomic RNA into ...the ... See full document
5
Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging
... for human APOBEC3G packaging into human immunodeficiency virus type 1 (HIV-1) ...Gag virus-like particles (VLP) that lacked all the viral genomic RNA packaging ... See full document
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Sequence-Specific Binding of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein to Short Oligonucleotides
... Cross-linking of short oligonucleotides by NC. In the course of our experiments to define a minimal stable binding site for NC, we found that initial experiments with the tetranucleotide TGTG failed to give reproducible ... See full document
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Genetic Analysis of the Localization of APOBEC3F to Human Immunodeficiency Virus Type 1 Virion Cores
... leucine residues play a role in mature core localization of ...C-terminal residues of A3F and ...boxed residues of A3C (amino acids 165 to 190) replaced the boxed residues of A3F-C (amino ... See full document
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Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.
... on virion formation and maturation. Virion content analysis showed that N-terminal basic residues are involved in the packaging of genomic RNA ...of residues R7, R10, and K11 to ... See full document
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The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.
... in virion structure and infectivity, we generated HIV-1 DNA mutants in the RAPRKK sequence of NCp7 and analyzed the mutant virions produced by transfected ...infectious virus (A30P) or noninfec- ... See full document
7
Basic Residues in Human Immunodeficiency Virus Type 1 Nucleocapsid Promote Virion Assembly via Interaction with RNA
... of virus-producing cells by electron microscopy showed that a higher proportion of mutant virions exhibit immature ...NC basic-residue mutations on virion morphology have been reported (4, ...per ... See full document
12
Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.
... Ten to 14 days posttransfection, when more than 70% of the transfectants expressed HIV-1-specific antigens, progeny virus present in culture supernatants was collected, filtered through [r] ... See full document
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Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein.
... To determine whether the amino acid changes in the MA protein domain that abolish virus replication affect viral particle assembly or release, the mutant proviruses were transfected into[r] ... See full document
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The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent.
... Infectivity assay of HIV-1 Zn2+ finger rearrangement mutants with HCLZ cells Virus pNC1/1 pNC2/2 pNC2/1 pNL4-3 wild type None calf thymus DNA Amt of p24A in inoculum no.. of ng/mla focib[r] ... See full document
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Selective Interactions of Polyanions with Basic Surfaces on Human Immunodeficiency Virus Type 1 gp120
... of human origin were used (their specificities are in parentheses): 21h (CD4 binding site [CD4bs]), 19b (V3 loop) (53), 17b, and 48d (CD4i epitope) (77) were from ...The human anti-gp120 MAb 2G12 (79, 80) ... See full document
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Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Human imm[r] ... See full document
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Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type 1 nucleocapsid protein
... in virion [20, ...the virion dose-dependently ...the virion proteins in a parallel comparison with bacterial cell lysates expressing the CA-NC fusion protein and identi- fied the 30 kD protein band ... See full document
15
Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain
... inhibit virus assembly (Fig. 1), suggesting that NC does not simply mask sequences which are toxic to virus ...facilitate virus-like particle release ...of virus-like ...wt human ... See full document
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