[PDF] Top 20 Human T-Cell Leukemia Virus Type 1 Tax Relieves Repression of Proliferating Cell Nuclear Antigen Gene Expression
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Human T-Cell Leukemia Virus Type 1 Tax Relieves Repression of Proliferating Cell Nuclear Antigen Gene Expression
... of Tax-mediated transactivation of the TATAA- less PCNA ...⫺ 1), ⌬ PIR, or ⌬ PDR sequences in a luciferase reporter plasmid were cotransfected into 293 cells together with the pRL-SV40 Renilla luciferase ... See full document
9
Costimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activator Tax.
... of T cells through their antigen-specific T-cell receptor results in the coordinate expression of a number of cytokine genes such as interleukin-2 (IL-2), IL-3, granulocyte- macrophage ... See full document
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Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator
... Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are complex retroviruses that persist in the host, eventually causing leukemia and neurological ... See full document
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Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax.
... of cell growth and differenti- ation (27), have been linked with certain leukemias (28, 40), and have been implicated in Tax-induced repression of b -poly- merase gene expression (52), ... See full document
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Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
... of T lymphocytes by HTLV-1 is due primarily to the expression of the 40-kDa Tax retrovirus oncoprotein, which deregulates a variety of impor- tant cellular processes (6, ...13). Tax has ... See full document
7
Mutational analysis of human T-cell leukemia virus type 2 Tax.
... Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) contain at least two trans-regulatory genes, tax and rex (23, 27, 39, ...Both ... See full document
6
The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.
... Human T-cell leukemia virus type 1 (HTLV-1) is a retrovi- rus associated with the development of adult T-cell leukemia (52, 86) and a ... See full document
14
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
... VCAM-1 gene, performed with the respective CAT reporter constructs transfected either in CEM cells in the presence of a Tax expression plasmid or in JPX-9 cells either induced or left ... See full document
9
CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein
... lanes 1 to 4, and C, lanes 1 to 2) or a second probe which contains a mutated ATF sequence (mATF) ...when Tax- expressing C8166-45 cells or MT4 cells were compared to Ju- rkat ...lanes 1 and ... See full document
13
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... The human T-cell leukemia virus type 1 (HTLV-1) transforming protein, Tax, is a potent transactivator of both viral and cellular gene ...of Tax ... See full document
10
Human T-Cell Leukemia Virus Type 1 Tax Protein Abrogates Interleukin-2 Dependence in a Mouse T-Cell Line
... Therefore, Tax and Tax703 proteins inhibited apoptosis of CTLL-2 cells in the absence of ...these Tax proteins induced IL-2-independent proliferation of CTLL-2, but TaxWT pro- duced a limited degree of ... See full document
7
APOBEC3G targets human T cell leukemia virus type 1
... of cell-free HTLV-1 virions, we could not detect p19 production in the supernatant of infection culture (data not ...of cell free virions of HTLV-1, which was very low ... See full document
10
Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein
... ATL cell lines, suggesting that it might play an unsuspected role in the biological process leading to ATLL development (28, ...reporter gene and the simian virus 40 poly(A) signal was cloned in the ... See full document
7
Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax
... plus Tax have increased chromosomal ...HTLV-1 Tax-neo, HA-PTTG-neo, or Tax plus HA-PTTG-neo were selected using ...(lane 1), HCT116-Tax (lane 2), HCT116-PTTG (lane 3), and ... See full document
8
Transmission of Human T-Cell Leukemia Virus Type 1 to Mice
... MT-2 cell DNA as the ...MT-2 cell DNA ...MT-2 cell DNA but not from mouse spleen DNA, indicating that the quality of MT-2 cell DNA is suitable for use as a template (data not ...MT-2 ... See full document
6
Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells
... viral gene expression may be ...HTLV-1 tax expression suggests that these stimuli may alter HTLV-1 pathogenesis in ...HTLV-1 gene ex- pression to different degrees ... See full document
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Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1
... by Tax 1. In order to determine the effect of Tax 1 on the ability of Sp1 to bind its responsive elements, we performed EMSAs using a probe containing the Sp1 consensus ...in nuclear ... See full document
7
Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein
... mutant Tax protein or the pCMV-1 negative control plasmid, and 1 mg of ...of Tax mutant proteins by the basal CAT activity in the presence of ...wild type. (B) Activation of endogenous ... See full document
6
Role of Tax protein in human T cell leukemia virus type I leukemogenicity
... of Tax which enhance mutations and other chromosomal aberrations and interfere with DNA repair should be expected to induce cell cycle arrest or ...the cell cycle arrest and ...of Tax on the ... See full document
24
Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
... the Tax-CBP/p300 interac- tion in cellular transformation by HTLV-1, a molecular clone (37) containing a valine 89-to-alanine mutation in the tax gene was constructed ...of Tax (amino ... See full document
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