[PDF] Top 20 Human neuronal in vitro model of the ischemic penumbra
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Human neuronal in vitro model of the ischemic penumbra
... hypoxia, neuronal networks were less resistant to a second period of low oxygen condi- tions (synchronicity was completely lost after 24 hours of re-oxygenation in all ...in vitro studies on rat brains ... See full document
45
Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging
... This pilot study was not designed to establish the superiority of one method over another, but to explore the relationship between T2*OC responsiveness and blood flow in the evolving stroke lesion: as such, it was not ... See full document
9
Original Article BET protein BRD4 as a new therapeutic target in cerebral ischemic stroke
... (MCAO) model of ischemic stroke in ...volume, neuronal apoptosis and neuroinflammatory response were examined 24 h after ...and neuronal apoptosis were all significantly inhibited in ... See full document
8
Improving Acute Stroke Management with CT Perfusion Imaging: Approaches to Treatment Guidance and Brain Tissue Salvage
... of penumbra to ...peri-procedural ischemic strokes, as detected by MR imaging, in patients undergoing endovascular repair of intracranial aneurysms 86 ... See full document
285
Recombinant human brain-derived neurotrophic factor prevents neuronal apoptosis in a novel in vitro model of subarachnoid hemorrhage
... animal model for SAH was established by directly injecting a hemolysate into the subarachnoid space of rats or ...in vitro applications of the hemolysate SAH model have not been reported, and the ... See full document
9
Intermittent Hypothermia Is Neuroprotective in an in vitro Model of Ischemic Stroke
... and neuronal death using cell counting kit (CCK-8), enzyme-linked immuno- sorbent assay (ELISA), BCECF AM, Fluo-3 AM, DCFH-DA and dihydroethidium (DHE), JC-1 staining and terminal deoxynucleotidyl ... See full document
9
Original Article Activation of STAT3 is involved in neuronal apoptosis in focal cerebral ischemia/reperfusion rats via Bcl 2/Fas pathway
... involved neuronal apoptosis in focal cerebral ischemia/reperfusion ...MCAO model was used to produce transient focal isch- ...the neuronal apoptosis were detected by TUNEL ...in ischemic zone, ... See full document
10
Human Embryo Neuronal Culture in Vitro: A Model to Study Cellular Physiology, Receptors, Power and Toxicity of Cytostatic Drugs for Human Use
... Metotrexate, competitive antagonist of the folic acid on catalytic site of the dihydrofolate reductase (DHFR), has an action which can be weakened by three factors: the reduction of polyglutamate inside the cell, ... See full document
6
Identifying and utilizing the ischemic penumbra
... the ischemic region evolve into irre- versible brain injury over time and that this evolution is most critically linked to the severity of the decline in cerebral blood flow ...The ischemic penumbra ... See full document
8
Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation
... with neuronal apoptosis and the production of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF- α ) and interleukin 1 β (IL-1 β ), which are favored by acting as perpetrators in the central nervous ... See full document
17
3-<em>n</em>-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke
... PC12 neuronal cells were purchased from the American Type Culture Collection and cultured in DMEM (Grand Island, NY, USA) supplemented with 10% FBS. Cultures were divided into four groups: the control group was ... See full document
11
Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury
... experienced ischemic/re- perfusion injury, we found that treatment with ZSTK474 inhibited the expression of Iba-1 and GFAP in the ische- mic penumbra, altered the phenotype of microglia/macro- phages to a ... See full document
11
The new language of cerebral ischemia
... of ischemic mechanisms has been vastly abetted by the use of transgenic and knockout mouse ...the neuronal isoform of nitric oxide syn- thase (NOS), smaller infarcts develop and the mice have less severe ... See full document
11
Thrombolysis in acute ischemic stroke: Experience from a tertiary care centre in India.
... acute ischemic stroke has undergone a sea of change with the introduction of intravenous thrombolysis ...and Penumbra trials in which patients with acute ischemic stroke were treated using ... See full document
6
Hyperglycemia and Stroke
... In response to an inflammatory stimulus, there is an increase in I kB kinase-α and I k B kinase-ß, which phosphorylate I kB and result in its ubiquitination and proteosomal degradation. Degradation of I k B results in ... See full document
6
Susceptibility Weighted Imaging in Acute Stroke with Co-morbids: Magnetic Resonance Imaging Protocol Revisited
... Not only veins but PVS can reflect small arteries with deoxyhemoglobin blood in the Penumbra area. Consistent with previous SWI studies [15,18,19], our study of 22 patients showed PVS in 15, microbleed in 6, and ... See full document
8
Cloning and in Vitro Expression of the Human Alpha‑Fetoprotein Gene
... cells. Human AFP are able to induce apoptosis and to inhibit growth of the tumor ...the human AFP. Complementary DNA encoding human alpha-fetoprotein was cloned into bacterial vectors under the ... See full document
6
Hyperbaric oxygen therapy after acute ischemic stroke with large penumbra: a case report
... chamber, model 3300, company’s name: Sechrist, Anaheim, CA, USA, year of manufacture: 2010) over a 2-week period that started in post-stroke day 2 (after stopping therapeutic hyperten- ... See full document
7
Diffusion Weighted Imaging of Acute Excitotoxic Brain Injury
... the penumbra by means of neuron-glial cell units and synapses via excitotoxic mechanisms ...of ischemic injury after occlusion of the middle cerebral ... See full document
13
Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice
... peri- ischemic angiogenesis, positively affecting the differenti- ation of endogenous neuroblasts and plasticity within the ischemic ...attenuate ischemic brain injury and improve neurobehav- ioral ... See full document
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