[PDF] Top 20 Identification of a functional receptor for granulocyte colony stimulating factor on platelets

... on platelets. The expression of G-CSF receptors on platelets was demonstrated by flow cytometry and radioreceptor ...direct functional influence on platelet response, the effects on platelet ... See full document

... the identification of an alternatively spliced isoform of the GM-CSFRa subunit in which Alu derived sequence is predicted to add 34 amino acids to the membrane proximal extracellular portion of the ...the ... See full document

... Acute myeloid leukaemia (AML) is a clonal disorder characterised by discordant proliferation and differentiation of primitive myeloid cells leading to excessive accumulation of malignant blast cells. AML incorporates a ... See full document

... any functional G-CSFR protein still produce mature neutrophils, albeit at a reduced level (17, ...significant functional defects suggesting that the G-CSFR is providing nonredundant signals essential for ... See full document

... (3). Granulocyte colony-stimulating factor (G- CSF) has been shown to upregulate IL-8 receptor expression on PMNs, suggesting a role for G-CSF in mod- ulating IL-8–stimulated PMN ... See full document

... terplay between the receptors in the process of an- giogenesis. Further functional studies aimed to ex- plore the issue are needed. It appears that G-CSFR presence has been observed in many cancer cells, e.g. ... See full document

... Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-monocyte colony-stimulating[r] ... See full document

... The Ras genes were first identified as the transforming agents of the H arvey and Kirsten murine sarcom a viruses (Harvey, 1964, Kirsten and Mayer, 1967). The isolated viruses were shown to contain viral Ras oncogenes ... See full document

... and functional repair mechanisms, including regeneration of cerebral white matter and improvement in neurocognitive ...a granulocyte-colony stimulating factor (G-CSF) receptor ... See full document

... hematopoietic factor granulocyte-colony stimulating factor (G-CSF) effectively reduces infarct size and improves functional outcome after various types of experimental stroke ... See full document

... the identification of new proinflammatory molecules as potential therapeutic ...that granulocyte-macrophage colony-stimulating factor (GM-CSF), known to be a hematopoietic ... See full document

... One aspect of our study, not previously encoun- tered in rG-CSF pharmacokinetic studies, was the extremely high pre-first-dose G-CSF serum and urine concentrations in our neutropenic neonates with sepsis and shock. The ... See full document

... growth factor receptor (EGFR) in the absence o f ligand has been demonstrated in the epidermoid carcinoma cell A431 and skin fibroblasts to have a receptor half life of 9 - 16 hours (Krupper al ... See full document

... TNF receptor (GITR), and CD40), adoptive T-cell therapies and chi- meric antigen receptor (CAR) T-cells, chemotherapy, RT, and targeted therapies as candidate agents for com- bination in this category ... See full document

... Although platelet parameters, including the mean platelet volume (MPV) and the platelet distribution width (PDW) have been routinely available to clinicians for some time, their role in the diagnosis and management of ... See full document

... ulocyte-colony stimulating factor-producing gallbladder can- cer without recurrence more than 2 years after resection: report of a ...with granulocyte colony-stim- ulating ... See full document

... cyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor and – more recently, for patients who fail to mobilize with a G-CSF or ... See full document

... With these gene and protein expression profiles, now we know that MDSCs utilize a number of mechanisms to suppress both the innate and adaptive responses of anti- tumor immunity, mostly through the direct inhibition of T ... See full document

... Staurosporine (Sigma Chemical Co., St. Louis, MO) as well as protease inhibitors can completely prevent G-CSF receptor downmodulation. Thus, it appears TNF may act as a regulator of G-CSF receptor ... See full document

... Treatment with G-CSF or GM-CSF enhanced cellular functions that were critical in infectious diseases, such as neutrophil, monocyte, and macrophage activation and increased circulating white blood cells [52-54]. In a ... See full document