[PDF] Top 20 Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis
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Identification of key genes and pathways in human clear cell renal cell carcinoma (ccRCC) by co-expression analysis
... between genes and penalize weak ...other genes for network generation. To classify genes with similar expression profiles into gene modules, average linkage hierarchical clustering was ... See full document
14
A nomogram based on 9-lncRNAs signature for improving prognostic prediction of clear cell renal cell carcinoma
... : renal cell carcinoma; ccRCC : clear cell renal cell carcinoma; UICC: Inter- national Union Against Cancer; AJCC: American Joint Committee on Cancer; ... See full document
15
Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing
... some genes regulating metabolism and angiogenesis [17, ...signaling pathways associated with metabolism, inflammation and angiogenesis, accelerating oncogen- esis consequently ...of ccRCC. However, ... See full document
12
Original Article Identifying RHEB as a metastatic driver in clear-cell renal cell carcinoma through bioinformatics analysis
... of genes expression between two groups, and 1207 genes have been selected and collected, including 724 of down-regulation and 483 of up-regulation, according to the ...to analysis the DEGs in ... See full document
12
Somatic mutations in renal cell carcinomas from Chinese patients revealed by targeted gene panel sequencing and their associations with prognosis and PD-L1 expression
... Renal cell carcinoma (RCC) is among the most common human cancers in the United States, with approximately 63,990 new patients and 14,400 deaths annually ...mainly clear cell ... See full document
6
<p>CircHIPK3 Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Cells Proliferation and Metastasis via Altering of miR-508-3p/CXCL13 Signal</p>
... with ccRCC. (A and B) The expression of circHIPK3 in ccRCC tissues and paired paratumor tissues was determined by a RT-qPCR ...of ccRCC tissues was measured by ISH ...of ccRCC patients ... See full document
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<p>KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo</p>
... the expression in human clear cell renal cell carcinoma (ccRCC) tissues and explore the effects of kinesin family member 4A (KIF4A) on ccRCC ...in ... See full document
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Construction of a novel gene-based model for prognosis prediction of clear cell renal cell carcinoma
... ROC analysis of each gene was performed and the results showed that the sensitivity and specificity of sin- gle parameter was poorer than that of five-gene prognos- tic signature, which suggested that the ... See full document
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Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma
... Localized renal cell carcinoma can be cured by surgery treatment, however, the survival rate of patients sharply declined once the disease became ...metastatic. ccRCC is usually resistant to ... See full document
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Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma
... (IL)-8 expression is ele- vated, during sunitinib resistance, which suggests that IL-8 is also an key contributor and a potential therapeu- tic target to reverse sunitinib resistance in ccRCC ... See full document
9
Identification of clear cell renal cell carcinoma and oncocytoma using a three gene promoter methylation panel
... methylated genes in RCC, which might be useful as diag- nostic ...on ccRCC, only, whereas other included the most frequent RCTs and identified specific methylation patterns for each subtype in general [22], ... See full document
9
Upregulation of Rarb, Rarg, and Rorc Genes in Clear Cell Renal Cell Carcinoma
... quantitative expression analysis of genes encoding nuclear receptors of retinoids in clear cell renal cell carcinoma in ...identify genes with the ... See full document
9
Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma
... altered genes in cancer patients (indicating less effort of cell homeostasis to protect their sequence/expression as for low plyers) and therefore targeting them may not bring much therapeutic ...the ... See full document
8
Identification of potential key genes associated with ovarian clear cell carcinoma
... gene expression datasets were retrieved from GEO, including microarray information of 27 OCCC samples and 30 normal ovary ...protein–protein expression analyses based on public databases were performed to ... See full document
10
Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma
... high expression subgroup by X-tile ...to analysis the correlation between characteristics variables and MUC3A ...regression analysis were performed for prognostic ...multivariable analysis was ... See full document
10
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
... tumor cell glycolysis, and altered metabolism through altered transcriptional ...and cell intrinsic metabolism of ccRCC TIL from 54 ...CD4 ccRCC TIL were only moderately affected, CD8 ... See full document
14
Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma
... a cell-surface glycoprotein on T cells, B cells, and macrophages that inhibits their ...metastatic renal cell carcinoma, nivolumab and ipilimumab were found to contribute to a response rate of ... See full document
5
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
... tumour-suppressor genes compared with cells expressing wild type VHL ...high expression of PAI-1 was associated with high tumour stage and significantly lower survival ... See full document
5
Alteration of ASIC1 expression in clear cell renal cell carcinoma
... Arrays were deparaffinized in xylene and hydrated in an alco- hol series. After deparaffinization, the arrays were treated with boiling citrate buffer (10 mmol/L; pH 6.0) for 2 minutes for antigen retrieval. The treated ... See full document
7
Prognostic role of CD82/KAI1 in multiple human malignant neoplasms: a meta-analysis of 31 studies
... CD82 expression could be a favorable prognostic factor of various ...subgroup analysis based on the characteristics of the individual studies, we observed the statistically significant outcomes when data ... See full document
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