[PDF] Top 20 Identification of three subtypes of triple negative breast cancer with potential therapeutic implications

... Conclusions Three TNBC subtypes were characterized in this work: one molecular apocrine and two basal-like with, inter alia, opposite immune ...different subtypes of TNBC identified ...these ... See full document

... Triple negative breast cancers (TNBCs) account for 15% of all breast cancers, and represent one of the most aggressive forms of the disease, exhibiting short relapse-free ...other ... See full document

... BC subtypes [ 12 ...non-neoplastic breast samples [ 17 , 18 ], using adjacent-to-tumour tissues as non-neoplastic ...adjacent-to-tumour breast tissue contains changes in DNA methylation that may ... See full document

... Recently, a dual-luciferase assay-based screening of 1563 compounds for STAT3 inhibitors was performed, leading to the identification of Bt354 [108]. Further stud- ies have shown that Bt354 inhibits STAT3 ... See full document

... Identification of robust biomarkers that can assist prediction of response to ICB is essential to further advance precision immunotherapy. The results of clinical trials highlighted the predictive value of immune ... See full document

... distinct subtypes of TNBC can be identified with putative molecular ...as identification of potential markers of response to ...The identification of cell lines representing TNBC tumor ... See full document

... Abstract Triple-negative breast cancer (TNBC) is an aggressive subset of breast carcinomas that lack expression of estrogen receptor (ER), progesterone receptor (PR), and human ... See full document

... lung, breast, brain, liver, colon cancer and ...new therapeutic strategies, mechanisms of tumor develop, and manifestation of cellular transformation to be used in the fight against ...and ... See full document

... diagnosed, identification of targeted therapy is of great significance through differences in the genetic profile of primary ...undergoing breast-conserving therapy had better outcomes than with modified ... See full document

... + breast cancer ...independent potential prognostic marker for disease-specific survival and disease-free survival of breast ...normal breast tissue, and overexpression of cyclin B1 was ... See full document

... pathologically defined TNBC (Fig. 2.2b) and in the integrative cluster 10 (Fig. 2.2c), which demonstrated high concordance with the basal-like molecular subtype. In addition, almost 50% (34/70) of the cases with copy ... See full document

... riple negative breast cancer (TNBC) is associated with a poor prognosis compared to other types of breast ...'triple negative' is not one homogenous tumor type, but rather is ... See full document

... different breast cancer subtypes, we should also reconsider our traditional concepts and beliefs regarding cancer risk ...ER- breast cancers may not be possible; these controversial ... See full document

... TNBC is a heterogeneous disease that comprising multiple intrinsic subtypes with different clinical outcomes (3). Owing to its genetic heterogeneity and acquired resistance, TNBC has a relatively higher relapse ... See full document

... of breast cancer ...receptor-positive breast cancer cells (group ...other breast cancer cells (Figure ...viability, breast cancer cells were cultured in medium ... See full document

... of breast cancer using the Kinex TM antibody arrays that can interrogate several hundred more proteins and phosphoproteins than RPPA and in a less complex fashion than mass spectroscopy-based ...identified ... See full document

... microdissected breast tumors recognized the classification of breast cancer to subgroups according to protein and phosphoprotein level ...non-microdissected breast tumors has been illustrated ... See full document

... Background: Triple-negative breast cancer (TNBC) is associated with characteristically poor ...with breast cancer. The identification of biomarkers that allow early ... See full document

... ABSTRACT Triple-negative breast carcinomas (TNBC) are characterized by particularly poor outcomes, and there are no established markers significantly associated with ...the potential lncRNAs ... See full document

... other therapeutic targets, such as αβ-crystallin, Sox2, embryonic transcription factor, osteopontin, phosphorylated glycoprotein, nestin and type 4 intermediate fi lament ... See full document