[PDF] Top 20 Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins
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Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins
... Institute of San Diego. The HBV-Tg lineages used in this study expressed HBV proteins of the ayw subtype, were produced as described previously, and are listed in Table 1 (16–18, 31, 33). For convenience, we ... See full document
12
Phosphorylation of hepatitis B virus precore and core proteins.
... To investigate whether the phosphorylation of core and precore proteins requires other HBV gene products, we fused the putative phosphorylation sites the carboxy terminus of the precore-[r] ... See full document
5
The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport.
... In order to investigate whether this sequence contains an unusual nuclear localization signal, a protein named lOG was created by fusing the proximal precore sequence to the amino termin[r] ... See full document
7
Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide.
... Since COS-7 cells transfected with pECE-PC did not synthesize detectable amounts of P21c, we cotransfected plasmids expressing core and precore proteins pECE-C and pECE-PC, respectively [r] ... See full document
6
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
... The hepatitis B virus (HBV) is an enveloped DNA virus whose ...critical core protein concentration threshold is reached inside the cell ...envelope proteins to produce infectious ... See full document
6
Original Article Association of hepatitis B virus basal core promoter T1762/A1764 and precore A1896 mutations with serum hepatitis B virus DNA load, hepatitis B e antigen status, serum α-fetoprotein and hepatitis B virus-related liver disease progression
... basal core promoter (BCP) T1762/A1764 dual mutation and precore (PC) A1896 mutation of HBV are associated with an increased risk of HBV- related liver disease ...the virus throughout the liver, and ... See full document
13
Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan
... Worldwide, hepatitis B virus (HBV) infection is a major health ...phases: immune tolerance, immune clearance, and residual or inte- grated phases (11, ...chronic hepatitis ... See full document
7
Immune-Induced Evolutionary Selection Focused on a Single Reading Frame in Overlapping Hepatitis B Virus Proteins
... enveloped virus with a partially double-stranded circular DNA genome of ...The precore core reading frame codes for the capsid protein (core) and for the hepatitis B e antigen ... See full document
9
Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication.
... S]methionine in methionine-free medium (200 mCi per 60-mm-diameter plate). After labeling, the media were harvested and cells were lysed with RIPA buffer (10 mM Tris-HCl [pH 8], 150 mM NaCl, 1% Triton X 100, 1% sodium ... See full document
7
Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise
... an immune complex equilibrium. The reactiva- tion phase, also called immune escape or HBeAg negative CHB, is associated with increased ALT levels and liver in- flammation, and the appearance of ... See full document
11
Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
... Hepatitis B virus (HBV) is the prototype member of the hepadnavirus family, a group of enveloped DNA viruses that primarily infect the ...active hepatitis, liver cirrhosis, and hepatocellular ... See full document
9
Hepatitis B Virus Core Related Antigens as Markers for Monitoring Chronic Hepatitis B Infection
... related proteins would continue to be produced for a certain period of time in spite of the achievement of adequate sup- pression of the viral DNA ...truncated precore protein, which is also detected by the ... See full document
6
Immune and Viral Profile from Tolerance to Hepatitis B Surface Antigen Clearance: a Longitudinal Study of Vertically Hepatitis B Virus-Infected Children on Combined Therapy
... HBV core immunodominant epitopes for T helper, T cytotoxic, and B lymphocytes was already detectable at TW2, while the patients were on lamivudine treatment alone, and became significant compared to the ... See full document
13
Expression of the hepatitis B virus core gene in vitro and in vivo.
... Extracts of three HBV-infected human livers lanes 1 to 3, in vitro-synthesized core proteins initiated at ATGs 1 lane P and 2 lane C of the C gene, and immunoprecipitated precore and cor[r] ... See full document
5
Enrichment of a Precore-Minus Mutant of Duck Hepatitis B Virus in Experimental Mixed Infections
... mutant virus was expressed that was sufficient to overcome its replication ...wild-type virus by the 2619A virus in these birds was correlated with elevated titers of anti- core ...wild-type ... See full document
7
Hepatitis B Virus Genotypes and Precore and Core Mutants in Brazilian Patients
... the virus isolates was later proposed dividing HBV into six genotypes (36–38), designated A to ...the core gene and was discovered in France and United States (49), and genotype H, which was found in ... See full document
6
Mutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
... chronic hepatitis and hepatocellular carcinoma (HCC). Hepatitis B infection leads to more than one million deaths every year ...immunodeficiency virus (HIV) is another important challenge in ... See full document
8
Hepatitis B Virus of Genotype B with or without Recombination with Genotype C over the Precore Region plus the Core Gene
... from hepatitis B e antigen to the corresponding antibody oc- curs earlier in HBV/B than HBV/C carriers, which is impli- cated in different severities of liver disease developing in them (13, ...HBV ... See full document
8
Detection of pre C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers
... and core region of hepatitis B virus (HBV) DNA by a polymerase chain reaction in 22 chronic ...9 hepatitis B e antigen-positive asymptomatic carriers, a single DNA band was ... See full document
10
Immune response to hepatitis A virus capsid proteins after infection
... the immune response of humans to viral capsid polypeptides of hepatitis A virus (HAV) after natural infection, which is very important for vaccine ...dominant immune response against VP1 (98% ... See full document
7
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