[PDF] Top 20 Impact of genetic polymorphisms on clinical response to antithrombotics

... the clinical implications of utilizing pharmacogenetic therapy is the impact of VKORC1 and CYP2C9 variants on warfarin ...in response to warfarin, a potentially dangerous medication that is cumber- ... See full document

... tumors often show high EGFR expression and/or increased gene copy number. The efficacy of cetuximab is demonstrated in the recurrent/metastatic (R/M) HNSCC settings of clinical trials: ECOG, Erbitux in First-line ... See full document

... in response to ...ABCC1 polymorphisms may have an effective impact on atorvastatin efficacy in reduction of LDL-C serum level in Iranian patients with primary ... See full document

... exploit genetic information in cancer treatment, we must adopt a comprehensive approach, assessing which genes play critical roles in the response to any given ...the response of individual patients: ... See full document

... Patients underwent external beam RT with a 10- 18MV linear accelerator. A 3D-CRT was used in all patients. Patients were treated in prone position with full-bladder. A dedicated up-down table was used for patient ... See full document

... poor response to DNP ...the clinical efficacy of DNP therapy in patients with mild-to- moderate AD; furthermore, CYP2D6 genotype analysis may be useful in identifying subgroups of patients with AD who ... See full document

... the impact of these characteristics on the pooled ...XPC polymorphisms and chemother- apy response was evaluated under a homozygote model (aa versus AA, allele A represents the major allele and ... See full document

... impact of expression of ABCB1 1236C > T, 2677G > T/A, and 3435C > T polymorphisms on the antiproliferative effects of imatinib, nilotinib, dasatinib, and ponatinib using K562 cell lines. They ... See full document

... with genetic variants that are common in the population, ie, typically vari- ants with minor allele frequencies of 5% or ...nucleotide polymorphisms [SNPs]) included on GWAS arrays are generally neutral ... See full document

... the impact of age, gender, segregation, socio-economic status, nutritional habits and genetic fac- tors on the development of acute appendicitis [8, ...ever, genetic predisposition is still very ... See full document

... seasonal response of many genetic polymorphisms [21–24] make Drosophila an excellent model system to study the impact of large-effect alleles segregating in natural populations on rapid ... See full document

... chemotherapy response, and OS patients with AA genotype in ERCC2 rs1799793 were likely to have bet- ter chemotherapy response, whereas the rs13181 poly- morphism was not associated with the chemotherapy ... See full document

... Frequencies and percentages were used to summarize cat- egorical data. For continuous data, median and range were used to describe centrality and dispersion, respectively. To test whether the genotype frequencies are in ... See full document

... treatment response and toxicity are influenced by the polymorphisms of this ...CYP2D6 polymorphisms in risperidone treatment in terms of basic knowledge, pharmacogenetics, effectiveness, adverse ... See full document

... all clinical traits are polygenic, raising the num- ber of potential phenotypes factorially; even the simplest genetic predictors lead to a range of ...these polymorphisms result in a large range ... See full document

... At the first glance, the exact test for 2 5 × 3 is almost impossible. However, Kreiner (1992) shows that a conditional independence test in a multidimensional table can be converted to a conditional independence test in ... See full document

... the genetic makeup of an individual affects his/her response to ...inherited genetic variation on drug response in patients by correlating gene expression or single nucleotide ... See full document

... 3. Huyck KL, Panhuysen CI, Cuenco KT, Zhang J, Goldhammer H, Jones ES, et al. The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. American ... See full document

... protein 2 or cluster of differentiation 26 (CD26). 22 ACE2 is also identi fi ed as the cell surface receptor for SARS-CoV-2 S-protein. 17 DPP4, the receptor for MERS-CoV, is expressed ubiquitously in many tissues – ... See full document

... drug response, we conducted stratified analyses of Asian, Caucasian and cisplatin- based ...platinum response in Asian population by pooling 12 studies [7, 21, 22, 35, 42-49] included 2570 subjects (OR = ... See full document