[PDF] Top 20 Indirect T cell allorecognition of donor MHC class I alloantigens
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Indirect T cell allorecognition of donor MHC class I alloantigens
... helper T cell clones (Sprent 1978a and ...that T cell depleted mice given thymuses carrying foreign MHC molecules produced T cells that were tolerant of both the host and graft ... See full document
264
Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... anti-human MHC class I, and anti-human MHC class II were diluted 1:50, and anti-human CD80, anti-human CD83, and anti-human CD86 were diluted ...in cell surface immune molecule ... See full document
10
Allorecognition by T Lymphocytes and Allograft Rejection
... alloreactive T cells in vitro and in ...blockade, donor- specific transfusion ...self-MHC class II molecules to mediate their suppress functions, they are thought to be non-antigen ...suppress ... See full document
10
Donor dendritic cell–derived exosomes promote allograft targeting immune response
... (a) donor intact MHC molecules to trigger activation of directly alloreactive naive CD8 T cells and (b) donor-derived peptides in recipient (self) MHC molecules to stimulate indirectly ... See full document
17
T cell responses to human platelet antigen–1a involve a unique form of indirect allorecognition
... HPA-1a–specific T cells do not exclusively recognize integrin β3 residue ...HPA-1a–specific T cells, we examined T cell activation and pep- tide-binding to APCs with peptides in which Leu33 ... See full document
15
Inhibition of allorecognition by a human class II MHC–derived peptide through the induction of apoptosis
... the T-cell response to, or recognition of, antigen in gener- ...to alloantigens but also autoantigens in the setting of autoimmune ...of T cells primed to ... See full document
10
Peptide–MHC class I tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations
... functional T cells (12, 18, 19) and have prompted suggestions that T cell immunology has be- come biased toward the type of cells amenable to detection with multimeric pMHC ...vaccinated donor ... See full document
18
Organizational Accessibility and Community Connections: Examining Changes in the Spatial Proximity of Pubic Housing Residents to Social Service Providers and Providers' Responses to Redevelopment
... NK cell cytotoxicity by measuring perforin and granzyme B ...NK cell (during primary infection) and CTL populations (during secondary infection) contained in PBMCs primarily release perforin and granzyme ... See full document
150
Tumor-specific CD4 T cells eradicate myeloma cells genetically deficient in MHC class II display
... an indirect mechanism that involves secretion of myeloma protein [20, ...constitutive MHC II expression, MOPC315 cells may start to express MHC class II under certain in vivo conditions, as ... See full document
8
CD4 T cell–mediated cardiac allograft rejection requires donor but not host MHC class II
... harvested donor heart was placed in 4°C saline until ...the donor aorta to the recipient aorta was made using running 10-0 nylon ...the donor pulmonary artery to the recipient IVC was made in similar ... See full document
9
Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction
... μm cell strainer, gently pressed through and washed through with cold RMPI/FCS2, and then transferred into a 50 ml conical ...the cell pellet was then resuspended in 15 ml PBS ...red cell lysis ... See full document
19
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... effective T-cells are those that rec- ognize target cells bearing low densities of cognate pMHC on their surface ...defined T-cell antigens indicate that the best T-cell agonists are ... See full document
21
Bhonsle, Latika (2012): Characterization of potentially autoaggressive brain infiltrating CD8+ T cells in multiple sclerosis patients. Dissertation, LMU München: Fakultät für Biologie
... same T cell clone may also express two distinct α-chains simultaneously, but inadequate mRNA preservation may allow the detection of only one α-chain from the ...during T cell ...the ... See full document
174
Characterization of the Cytolytic T-Lymphocyte Response to a Candidate Vaccine Strain of Equine Herpesvirus 1 in CBA Mice
... pneumonitis, cell-associated viremia, and abortion (5, ...and T-cell responses; thus, the role of distinct immune functions conferring protection is not clearly ...specific cell population ... See full document
7
Investigating and Manipulating Major Histocompatibility Complex (MHC) Class I-Restricted Peptide Epitopes and Cognate T-cell Responses.
... diabetogenic T-cell clones via anergy induction, phenotype conversion, or clonal deletion; and ultimately, to restore the balance of islet-specific effector and suppressor T cells in at-risk ...CD8+ ... See full document
192
Immunoinformatics-Guided Designing of an Epitope-Based Vaccine Against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein
... A recent review documented that the particular genomic and proteomic analysis of respective proteins of SARS-CoV-2 including M, SGP, E, N proteins propounds the eligibility in representing protective immune responses ... See full document
42
Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein.
... In this report we investigate the number of T-cell epitopes in the Gag protein that are recognized by CTL from a sample of HIV-1-infected individuals with MHC class I polymorphisms that [r] ... See full document
9
Equine Herpesvirus Type 1-Mediated Oncolysis of Human Glioblastoma Multiforme Cells
... caballus MHC-I has been shown to be an entry recep- tor for EHV-1 ...glioma cell lines expressed human MHC-I and whether this expression is correlated with ...express ... See full document
5
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... HCC cell lines tested express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...the class I ... See full document
10
Peripheral blood T cells and neutrophils from asthma patients express class-I MHC-restricted T cell-associated molecule
... Class-I MHC-restricted T cell-associated molecule (CRTAM) was initially described as a protein expressed only on activated NKT cells and CD8 T cells ...CD4 T cells. The ... See full document
6
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