[PDF] Top 20 Individual participant data meta-analysis of prognostic factor studies: state of the art?

... using individual participant data (IPD) [12], where the raw data are obtained from multiple studies and synthesised, has been championed as a potential solution for synthesising ... See full document

... included studies, meta-analyses (MA) of aggregated data (AD, hereinafter referred as AD-MA) were not conducted in the above ...current state of scientific knowledge on treatment predictors and ... See full document

... IPD meta-analysis scenario where IPD studies are obtained and then ...multiple studies in the ...IPD meta-analysis of prognostic factor [37] and modelling [16] ... See full document

... confounding factor of the sex differences in stroke severity in several (5/6) ...biomarker data of the severity of stroke may provide a better assessment of severity than a single instrument like the ... See full document

... risk factor variables as were possible, but we acknowledge that the effects reported could be caused by residual confounding, although this would be ...of studies that did not have data on SES ... See full document

... the data generating ...IPD meta-analysis of randomised trials, the simulation-based approach could be equally used to esti- mate power for other IPD meta-analysis research, such as ... See full document

... single factor to determine success is maternal ...and individual dose adjustments are often ...conventional meta-analyses is difficult and many studies report test accuracy of these continuous ... See full document

... nonmeta- analysis settings have also identified the danger of ignoring clustering, such as in cluster randomized trials [33,34] and multicentre randomized trials ...regression analysis of a clinical trial ... See full document

... control studies published in English, French, Spanish, and German, and must have reported IPD on pregnancy as a risk factor for influenza-associated mortality (primary out- come) and/or influenza associated ... See full document

... the individual outcomes using a generalized linear model (GLM) with a normal distribution with a standard deviation of 1 and an identity link for the continuous outcomes, a Bernoulli distribution and logit link ... See full document

... (FE) meta-analysis methods (which assume that individual studies are estimating the same underlying treatment effect) and random effects (RE) methods (which assume that different ... See full document

... exchange data from various ...the data from any research project with NIH grants exceed- ing US$500,000 ...disease-specific data repositories that primarily, but not exclusively, host data ... See full document

... In this study, we utilised prospectively collected longitu- dinal data on alcohol consumption from six cohorts to examine the association of 10-year drinking trajectories and risk of developing and/or dying from ... See full document

... [33], meta-analysis of IPD will be con- ducted with both two- and one-stage ...primary studies in order to generate study-level effect size point estimates and ...conventional meta-analytical ... See full document

... case-control analysis from the California Cerebral Palsy project investigating whether in utero exposure to magnesium sulphate was associated with a lower prevalence of cerebral palsy in low birth weight infants ... See full document

... In addition to the one-stage IPD, we performed a two-stage IPD to examine the effects of study-level variables. We calculated the odds ratio (OR) of deterioration for each study and we pooled the out- comes using a ... See full document

... Microaspiration of contaminated oropharyngeal and gastric secretions is the main mechanism of entry of bacteria into the lower respiratory tract [9, 10]. Local and general host defenses play an important role in the ... See full document

... Data for this research were provided by Pfizer’s Clinical Trial Data Request Program (Study ID# WI205957). Pfizer had no role in the study design, data collection, statistical analysis, ... See full document

... this meta-analysis were Chinese, the results of this study cannot be extended to all populations; secondly, different lncRNAs were used to assess the prognosis of HCC, and there was a lack of specific ... See full document

... the data collection proforma; secure data handling; review the publication strategy for the collaboration; ensure that data are only used, and any additional research (including updating of the ... See full document