[PDF] Top 20 Induced pluripotent stem cells: advances to applications

... way, stem cell-based regenerative medicine is expected to drive the evolution of medical sciences from palliation, which mitigates symptoms, to curative therapy aimed at treating the root cause of degenerative and ... See full document

... called induced pluripotent stem cells (iPSCs) allows to reprogram the patient ’ s somatic cells to a pluripotent state by the forced expression of a defined set of transcription ... See full document

... of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing ... See full document

... Purkinje cells to model developmental and disease- relevant ataxia ...Purkinje cells only showed abnormal dendritic development upon stress but not under normal culture conditions, suggesting that ... See full document

... a pluripotent state, VPA enables repro- gramming with OS alone with an efficiency similar to that of OSK, suggesting that VPA treatment effectively obviates the need for Klf4 ... See full document

... Induced pluripotent stem cellsare generated by the genetic reprogramming of somatic cells by certain factors which are important in producing an embryonic stem cell-like state with ... See full document

... human induced pluripotent stem cells were differentiated into endothelial cells and then injected into immunodeficient mice with ischemic ...positive cells and transplanted them ... See full document

... somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly ... See full document

... Continuous advances in science and technology have been slowly increasing the mean life expectancy on a global ...recent advances using induced pluripotent stem cells gen- erated ... See full document

... pre-clinical stem cell therapies due to their physiological and morphological similarity to humans [28, 29], but they also may greatly benefit from pluripotency in vitro to the generation of genetically su- perior ... See full document

... cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative ...using ... See full document

... The efficiency of induction is increased by many additional genes which have been identified as members of the Klf family such as Klf1, Klf2, Klf4, and Klf5; the Myc family such as c-myc, L-myc, and N-myc; Nanog, and ... See full document

... heal. Induced pluripotent stem cells will likely focus more on disease treatment while embryonic stem cells will concentrate on debilitating injuries and degenerative disorders ... See full document

... the advances made in scientific research and medical treatment of cardiovas- cular diseases, there are still patients who die from these diseases every ...allogeneic stem cells isolated from ... See full document

... In combination with state-of-the-art bioanalytical methods, hESC-CMs have been reported as an alterna- tive model for in vitro cardiotoxicity [6, 7]. Navarrete and colleagues [8] reported that hiPSC-CMs can recap- ... See full document

... human pluripotent stem cells (hPSCs), including embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), as useful models for trophoblast differentiation; ... See full document

... neural stem cells; aiPSC: Artificially-induced pluripotent stem cells; ALP: Alkaline phosphatase; ASCs: Adult stem cells; a-SMA: Alpha-smooth muscle actin; BDNF: ... See full document

... iSCPs: Induced-Schwann cell precursors; iSCs: iSCP-derived Schwann cells; iPSC: Induced pluripotent stem cells; hESCs: Human embryonic stem cells; NCSCs: Neural ... See full document

... Next, the cultivation medium of the terminally differ- entiated GMSLNs was withdrawn 30 min after incuba- tion with cells and subjected to high-performance liquid chromatography analysis for GABA secretion. Conse- ... See full document

... iPS cells may be to down-regulate p53 and counteract this pro- apoptotic effect of c-Myc (Rowland et ...transforming cells, c-Myc may also play a role in loosening chromatin ...as pluripotent ... See full document