[PDF] Top 20 HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
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HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
... IMPORTANCE Endogenous retroviruses inhabit big portions of our ...accurate HERV-K HML-2 expression ...study HERV-K expression in the presence or absence of ... See full document
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HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses In Vivo but Not to Increased Virion Production
... in HML-2 RNA was assessed in PBMCs from HIV-1-infected patients in the absence or presence of antiretroviral therapy (P ⬍ ...of expression was about 2-fold higher than that seen ... See full document
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Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1
... Recombinant HIV-1 Tat activates HERV-K (HML-2) gene ...from cells that were subjected to different Tat treatments and amplified by one-step Sybr green real-time qRT-PCR ... See full document
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Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3
... to HERV-K, is not initiated at a TATA motif present in the LTR but is mediated by Sp1 or Sp3 protein binding to several GC boxes in the vicinity of the TSS, although the involvement of an Inr has often been ... See full document
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HIV-1 Interacts with Human Endogenous Retrovirus K (HML-2) Envelopes Derived from Human Primary Lymphocytes
... modern-day HERV-Ks are still expressed in primary lymphocytes and could play a role in the HIV-1 life ...artificial HERV-K consensus sequence which resembles that of an ancestral ... See full document
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Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein
... 2012. HIV infection and HERV expression: a ...Clayton K, Duan E, Song H, Xu Y, Sengupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski ...2012. ... See full document
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Staufen-1 Interacts with the Human Endogenous Retrovirus Family HERV-K(HML-2) Rec and Gag Proteins and Increases Virion Production
... in cells that express viral RNA but not in mRNA-decay- related processing ...and HERV-K(HML-2) Gag ...full-length primary transcripts into particles in the ...export ... See full document
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Human endogenous retrovirus HERV K(HML 2) encodes a stable signal peptide with biological properties distinct from Rec
... and HML-2 SP are processed in the same ...to HML-2 type 2 proviruses argues for a vital role of SP in the former viral life ...that HML-2 SP served to back up or modulate ... See full document
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Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV 1 infection
... various HIV-1 infected cell ...of HIV-1 associated changes in HERV transcription pattern than clinical samples and provides the appropriate controls to evaluate expression of ... See full document
17
Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
... chronic HIV-1 infection and have implications for both a better understand- ing of HIV-1 pathogenesis and a potential new approach to HIV-1 ...the primary advantage ... See full document
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Human Endogenous Retrovirus K(HML-2) Gag- and Env-Specific T-Cell Responses Are Infrequently Detected in HIV-1-Infected Subjects Using Standard Peptide Matrix-Based Screening
... by HIV-1 to favor retroviral expression may result in the expression of HERV ...of T-cell responses to peptides derived from diverse HERV families, selected for their ... See full document
5
Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV 1 latency
... analysed expression of HERVs in uninfected or HIV-1-infected primary CD4 + T cells from three individual donors with or without panobinostat treat- ...These cells ... See full document
11
The HERV-K Human Endogenous Retrovirus Envelope Protein Antagonizes Tetherin Antiviral Activity
... against HIV-1, has been proven to counteract numerous enveloped ...producer cells, keeping them tethered to the cell ...that human HERV-K(HML2) elements, the remnants of ... See full document
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HERV-K(OLD): Ancestor Sequences of the Human Endogenous Retrovirus Family HERV-K(HML-2)
... of HERV-K homol- ogous sequences in Old World primates, we observed a second mutational event that emerged at the same time in evolution, leading to a shortened gag gene ...of ... See full document
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CpG Methylation Directly Regulates Transcriptional Activity of the Human Endogenous Retrovirus Family HERV-K(HML-2)
... Specific PCR primers were located between 32 and 85 bp upstream from the 5 ⬘ LTR. Due to a large amount of repetitive elements upstream from some of the LTRs, a nested PCR approach was employed to generate ... See full document
8
Human-Specific Integrations of the HERV-K Endogenous Retrovirus Family
... of endogenous retrovirus-like sequences (HERVs) exist in the genomes of humans and other ...the HERV-K group, contains members that encode functional proteins and that have been implicated in ... See full document
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HERV K–specific T cells eliminate diverse HIV 1/2 and SIV primary isolates
... kill cells infected with this ...the infection with 99UG_A0848M1 was particularly potent, such that the majority of cells were immediately infected by our synchronized magnetofection ...these ... See full document
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Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer
... replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic ...certain human tumor cell lines have been shown to release ... See full document
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Expression analysis of the human endogenous retrovirus HERV K in human astrocytic tumors
... tumor specific antigens may be an option and HERV-K splice products could serve as ...Furthermore, HERV- K derived proteins may play a role during the tumorigenic ...the ... See full document
6
Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.
... the human endogenous retrovi- rus HTDV/HERV-K exists in ...Positive human sera clearly label HTDV particles in immunofluorescence and im- munoelectron ...cle-producing cells, two ... See full document
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