[PDF] Top 20 Inhibition of HIV 1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression
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Inhibition of HIV 1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression
... for HIV-1, Jurkat cells were transfected with 2 different siRNAs targeting GliPR, control non-silencing siRNA, or mock transfec- tion without any ...mRNA expression was reduced by around 64% to 69% ... See full document
10
Excessive RNA Splicing and Inhibition of HIV-1 Replication Induced by Modified U1 Small Nuclear RNAs
... virus replication should be inhibited by promoting excessive splicing of HIV-1 RNA and reducing the amount of unspliced viral RNA available for synthesis of Gag and for use as genome ...of ... See full document
11
DBR1 siRNA inhibition of HIV 1 replication
... siRNA expression reduced the level of DBR1 mRNA in a dose and time dependent manner and decreased the amount of virus produced from infected ...siRNA-mediated inhibition of HIV-1 ... See full document
9
Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers.
... the inhibition of any retrovi- rus. It is our hope to develop HIV-1 PR as an antiviral gene, with the goal of application of this technology to the inhibition of HIV-1 ... See full document
7
Strong In Vivo Inhibition of HIV 1 Replication by Nullbasic, a Tat Mutant
... NB-ZSG expression was maintained in ⬃ 80% of the CD4 ⫹ cells over 39 ...for HIV-1 replication because it stimulates transcription from the viral promoter by interaction with P-TEFb and then ... See full document
17
Inhibition of Early and Late Events of the HIV-1 Replication Cycle by Cytoplasmic Fab Intrabodies against the Matrix Protein, p17
... Inhibition of HIV-1 Proviral Gene Expression of CD4+ Jurkat T Cells Stably Expressing Cytoplasmic Anti-MA Fab3H7 Intrabodies. The ability of cytoplasmic Fab3H7 intrabodies to inhibit HIV[r] ... See full document
15
APOBEC3G UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV 1 replication
... fusion protein is indeed more resistant to Vif-mediated degradation than ...fusion protein was found to bind less polyubiquitin than APOBEC3G, suggesting that UBA2 stabilizes APOBEC3G by preventing ... See full document
13
Efficient inhibition of HIV 1 replication by an artificial polycistronic miRNA construct
... we did not observed any off-target effects of miR-ACB by evaluating cell proliferation rate, interferon response, and interruption of native mRNAs. The strategy described here provides a method to con- struct miRNA ... See full document
11
Endoribonuclease-Prepared Short Interfering RNAs Induce Effective and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication
... Short interfering RNAs (siRNAs) targeting viral or cellular genes can efficiently inhibit human immunodeficiency virus type 1 (HIV-1) ...optimal HIV-1 gene silencing by ... See full document
7
Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary Macrophages by Using Tat- or CCR5-Specific Small Interfering RNAs Expressed from a Lentivirus Vector
... erase expression by the infecting indicator virus, while the wild-type Tat expression plasmid pHIV/Tat had little or no positive ...of HIV-1 replication and gene expression was ... See full document
9
Modulating HIV 1 replication by RNA interference directed against human transcription elongation factor SPT5
... and HIV-1 ...of expression that were still sufficient for hSpt5 to carry out its essential ...RNAi against hSpt5 as a potential therapeutic strategy for fighting HIV-1 infection ... See full document
13
Inhibition of HIV Replication by Apolipoprotein A I Binding Protein Targeting the Lipid Rafts
... affect HIV-1 replication in the cells with HLA-B*35 genotype whereas it did significantly increase virus replication in cells with other HLA ...with HIV susceptibility or control ... See full document
20
In vivo analysis of highly conserved Nef activities in HIV 1 replication and pathogenesis
... and inhibition of ASK1 ...on HIV-1 infection in vivo ...the protein for regions of special signifi- cance for viral replication and ... See full document
16
Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin
... Results: Chemically synthesized siRNAs were designed to target the mRNA produced by the three genomic segments. We first demonstrated that the siRNAs targeting the NP mRNA displayed a stronger antiviral effect than those ... See full document
11
Inhibition of Severe Acute Respiratory Syndrome Virus Replication by Small Interfering RNAs in Mammalian Cells
... average reference C t value from the average target C t value. The ⌬⌬C t value involves subtraction by the ⌬Ct experimental control value. RESULTS Inhibition of CPE of SARS-CoV by siRNA. To study the CPE of ... See full document
5
Alternative Approaches for Efficient Inhibition of Hepatitis C Virus RNA Replication by Small Interfering RNAs
... Heidelberg, 1 and Max-Planck-Institute for Molecular Cell Biology and Genetics, D-01307 Dresden, 2 Germany Received 8 October 2003/Accepted 4 December 2003 Persistent infection with hepatitis C virus (HCV) is a ... See full document
11
Hypomethylation and aberrant expression of the glioma pathogenesis related 1 gene in Wilms tumors
... GLIPR1/RTVP-1 was demonstrated in prostate cancer, impli- cating it as a putative tumor-suppressor gene [28]. We were therefore prompted to evaluate its epigenetic status in WTs relative to normal fetal and ... See full document
9
Glioma Pathogenesis Related Protein 1: Tumor Suppressor Activities and Therapeutic Potential
... GLIPR1 as a therapeutic agent Elucidation of the unique tumor-suppressor properties of GLIPR1/Glipr1 led to the notion that GLIPR1 treatment may be effective for local and/or systemic control of prostate cancer and, ... See full document
5
Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs
... a replication-inactive initiation complex ...DNA replication. The isolation of identical sequences for both RNAs B-5-1 and B-5-8 suggests that they do not belong to a family of highly repeated ... See full document
11
Inhibition of Coxsackievirus B3 Replication by Small Interfering RNAs Requires Perfect Sequence Match in the Central Region of the Viral Positive Strand
... of small interfering RNA (siRNA) in knockdown of gene expression is an emerging technology in antiviral gene ...protect against CVB3 infection, we evaluated the effects of RNAi on viral ... See full document
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