[PDF] Top 20 Insights into the Complexity and Functionality of Hepatitis C Virus NS5A Phosphorylation
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Insights into the Complexity and Functionality of Hepatitis C Virus NS5A Phosphorylation
... subsequent phosphorylation at S41, S37, and S33 by GSK-3 ...for NS5A, and intriguingly, S222 and S225 are predicted to constitute GSK3 phosphorylation ...mimicking phosphorylation, the S238D ... See full document
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Insights into the complexity and functionality of hepatitis C virus NS5A phosphorylation
... subsequent phosphorylation at S41, S37, and S33 by GSK-3 ...for NS5A, and intriguingly, S222 and S225 are predicted to constitute GSK3 phosphorylation ...mimicking phosphorylation, the S238D ... See full document
13
Identification of a novel phosphorylation site in hepatitis C virus NS5A
... of NS5A is depicted, showing the location of the ...and NS5A was purified by using protein G beads and a polyclonal sheep anti- NS5A serum (Macdonald et ... See full document
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Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.
... of NS5A phosphorylation, pulse-chase and mutation analyses were per- ...that phosphorylation on NS5A took place after completion of the proteolytic cleavages at the N and C termini of ... See full document
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A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
... of NS5A does not discriminate between hyper- and hypophosphorylated forms, we wanted to determine if serine 222 was a discrete component of one form over the other or a component of both ...prepared, NS5A ... See full document
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Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase.
... For PPM, excised strips containing the phosphoprotein of interest were wetted briefly in methanol followed by water, incubated in 0.5% polyvinylpyrrolidone- 360–100 mM acetic acid for 30 min at 37°C to block ... See full document
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Regulation of hepatitis C virus replication via threonine phosphorylation of the NS5A protein
... infectious virus, in vitro tran- scripts of either wild-type or mutant full-length mJFH-1 virus RNA were electroporated into Huh7 ...infectious virus, with the only significant reductions being ... See full document
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Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein-protein interactions.
... distinct NS5A species is a technical challenge which is limited by the sensitivity of mass spectrometric ...an NS5A species that was phosphory- lated within LCSI only on S222 and S225 ...during virus ... See full document
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Serine Phosphorylation of the Hepatitis C Virus NS5A Protein Controls the Establishment of Replication Complexes
... for NS5A to dimerize, while domains II and III are intrinsically disordered but have recently been shown to have elements of transient sec- ondary structure throughout ...domains. NS5A exists in two ... See full document
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Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions
... distinct NS5A species is a technical challenge which is limited by the sensitivity of mass spectrometric ...an NS5A species that was phosphory- lated within LCSI only on S222 and S225 ...during virus ... See full document
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Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes
... for NS5A to dimerize, while domains II and III are intrinsically disordered but have recently been shown to have elements of transient sec- ondary structure throughout ...domains. NS5A exists in two ... See full document
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The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation.
... HCV NS5A region, a series of plasmids were constructed by ...its C terminus. The checkered box indicates E tag fused in frame at the C-terminal end of the HCV polypeptide (abbreviated E in the ... See full document
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Hepatitis C Virus NS5A Disrupts STAT1 Phosphorylation and Suppresses Type I Interferon Signaling
... GT1 NS5A suppresses IFN responsiveness more strongly than GT3 NS5A in conjunction with stronger binding to ...through C-terminal NS5A binding to STAT1, which results in reduced P-STAT1, ISRE ... See full document
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Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action
... for hepatitis C virus (HCV)-infected patients consists of lengthy treatment with interferon and ...HCV-encoded NS5A protein has emerged as a promising DAA ...targeting NS5A exhibit ... See full document
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Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.
... However, in the present study, we were not able to observe elevated levels of apoptosis in either HEK293 or Huh7 cells following overexpression of Kv2.1 (data not shown). We con- FIGURE 8. A model of NS5A ... See full document
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Regulation of the Production of Infectious Genotype 1a Hepatitis C Virus by NS5A Domain III
... Although hepatitis C virus (HCV) assembly remains incompletely understood, recent studies with the genotype 2a JFH-1 strain suggest that it is dependent upon the phosphorylation of Ser ... See full document
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Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
... protein NS5A of hepatitis c virus (HCV) has been demonstrated to be a phosphoprotein with an apparent molecular mass of 56 ...of NS5A (p58) by additional phosphorylation ...with ... See full document
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Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase
... 3. c-Abl phosphorylates NS5A at Tyr 330 ...or c-Abl shRNA-encoding ...phosphorylated NS5A was evaluated by anti-phosphotyrosine (p-Tyr) ...of NS5A. B, COS-7 cells were transfected with ... See full document
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Identification of Hepatitis C Virus NS5A Inhibitors
... the NS5A protein of HCV can be targeted by small molecules, resulting in specific and potent ...of NS5A is still poorly understood, and no enzy- matic activity has been ascribed to ...interesting ... See full document
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Antigenic Heterogeneity of the Hepatitis C Virus NS5A Protein
... of hepatitis C virus (HCV) on the antigenic properties of the NS5 protein was studied by using recombinant ...HCV NS5A protein at amino acids 2212 to ...the NS5A immunodominant ... See full document
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