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Integrase and integration: biochemical activities of HIV 1 integrase
... Abstract Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive ...infection. Integrase, a retroviral enzyme, catalyses ...of ... See full document
13
GCN5 dependent acetylation of HIV 1 integrase enhances viral integration
... grated HIV-1 DNA, while stable knockdown cell clones were processed two weeks after infection using primers specific to the luciferase ...non-integrated HIV-1 DNA and avoid cross-reaction with ... See full document
16
Human Immunodeficiency Virus Type 1 (HIV-1) Integrase: Resistance to Diketo Acid Integrase Inhibitors Impairs HIV-1 Replication and Integration and Confers Cross-Resistance to l-Chicoric Acid
... of HIV IN has been a subject of intense research, the lack of a full-length IN crystal structure has hindered the identification and development of clinically useful IN ...on HIV replication and ... See full document
13
Peptides derived from the HIV 1 integrase promote HIV 1 infection and multi integration of viral cDNA in LEDGF/p75 knockdown cells
... 31. Jenkins TM, Engelman A, Ghirlando R, Craigie R: A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization. J Biol Chem 1996, ... See full document
11
Uneven Genetic Robustness of HIV-1 Integrase
... The HIV-1 integrase (IN) protein is responsible for the integration of the viral genome into the host cell ...during HIV-1 infection. Previously, we measured the robustness of ... See full document
16
Progress in development of HIV 1 integrase inhibitor
... the HIV genomic RNA is uncoated and ...by HIV protease occurs, leading to morphological maturation of ...of HIV-1 presents several viable targets that could be exploited for the development of ... See full document
15
CURRENT STATUS OF HIV-1 INTEGRASE INHIBITORS
... of HIV have been identified, HIV-1 and HIV-2. While HIV-2 is spreading in India and West Africa, HIV-1 is more virulent and the number one cause of AIDS ...with HIV ... See full document
14
Biochemical and virological analysis of the 18 residue C terminal tail of HIV 1 integrase
... of HIV-1 integrase yet to be visualized by structural ...in integrase function and HIV-1 replication, a set of deletion mutants that successively lacked three amino acids was ... See full document
13
Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors
... ring of raltegravir is nicely inserted into the cavity (Figure 6-13) that is formed by displacement of the 3ƍ-adenosine the when viral DNA associates with integrase in a pre- integration complex. This ... See full document
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Inhibition of HIV 1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
... In the present work, we further confirm and emphasize the role that importin α plays in promoting nuclear import of the viral IN and thus in virus infection. Multiple approaches and various experimental systems such as ... See full document
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Mutations Located outside the Integrase Gene Can Confer Resistance to HIV 1 Integrase Strand Transfer Inhibitors
... the integrase strand transfer inhibitors raltegravir and elvite- gravir is often due to well-identified mutations in the integrase ...type 1 (HIV-1) Lai. After integration into ... See full document
11
Isolation and Characterization of an Oligomerization-Negative Mutant of HIV-1 Integrase
... of HIV-1 had profound effects on HIV-1 ...viral integration in vivo and indicates that proper oligomerization of IN is essen- tial for viral ... See full document
12
Characterization of the HIV 1 integrase chromatin and LEDGF/p75 binding abilities by mutagenic analysis within the catalytic core domain of integrase
... This suggests that the chromatin association of IN, rather than LEDGF/p75 binding, is essential for HIV-1 infection. These results are consistent with the previous study by Shun and his co-workers in which ... See full document
14
Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitro.
... type 1 (HIV-1) integrase (IN) catalyzes the integration of viral DNA into the host chromosome, an essential step in retroviral ...against HIV-1 IN were ...vitro ... See full document
8
Histone deacetylase 1 interacts with HIV 1 Integrase and modulates viral replication
... viral integration and can potentially lead to the development of new antiviral ...for integrase-containing complex followed by mass spectrometry ...with HIV-1 ...of HIV-1 ...in ... See full document
17
Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir
... e Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of HIV-1 integrase to irreversibly link the reverse-transcribed viral DNA to the host ... See full document
10
Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
... of HIV-1 replication including virion maturation, reverse transcription, nuclear import, and integration (see Introduction), suggesting that it may be the combination of multiple inhibitory processes ... See full document
190
Comparative biochemical analysis of HIV 1 subtype B and C integrase enzymes
... Competing interests The authors declare that they have no competing interests. Authors' contributions TB designed all of the biochemistry and enzyme experi- ments performed in this assay. She wrote the first draft of the ... See full document
10
DNA damage enhances integration of HIV 1 into macrophages by overcoming integrase inhibition
... with HIV-1 virus and an adenovirus that expressed rare- cutting endonucleases such as I-SceI or I-PpoI, we reprodu- cibly observed that the viral DNA was integrated into the corresponding DSB ...viral ... See full document
18
Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation
... of HIV-1 replication, including virion maturation, reverse transcription, nuclear import, and integration (see the introduction), suggesting that it may be the combination of multiple inhibitory ... See full document
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