[PDF] Top 20 Towards an integrated view of Wnt signaling in development

... studying Wnt signal transduction have focused on resolving the biochemical nature of downstream signaling ...given Wnt signal is highly ...about signaling events that also integrates more ... See full document

... the development and homeostasis of virtually all ...many Wnt signaling components and have revealed their underlying ...by Wnt proteins and β -catenin. For example, although structures of ... See full document

... during development and adult- hood (for a review, see ...of Wnt signaling components during development of the CNS has also been ...of Wnt signaling in the developing neural tube ... See full document

... Wnt signaling has been implicated in postnatal bone mass homeostasis. Wnt molecules exert their functions by activating several distinct intracellular pathways, including that mediated by β -catenin, ... See full document

... embryonic development, the inner ear depends on signaling information originating from the embryonic hindbrain to establish dorsoventral and anteroposterior ...and Wnt signaling pathways are ... See full document

... these signaling events leads to a diverse array of devastating diseases including ...embryonic development by providing both quantitative and directional ...on Wnt signaling pathways in ... See full document

... 2008). Wnt signaling has been implicated in cancers, degenerative diseases, injury, and other post developmental ...understood Wnt signaling system is the canonical pathway ...canonical ... See full document

... that Wnt/β- catenin signaling is also involved later in neural crest cell fate specification after crest cells have been ...of Wnt/β-catenin signaling in pre-migratory zebrafish neural crest ... See full document

... factor signaling pathways, such as VEGF, TGF β , BMP4 and hedgehog, have been identified that are required directly or indirectly for formation of both lineages (Dickson et ...-catenin signaling plays a key ... See full document

... gonadal development and sex maintenance were found, including the Wnt signaling pathway (103; 2 %) and progesterone-mediated oocyte maturation (77; ... See full document

... cell development, the loss of β -cat in a transgenic mouse model did not significantly perturb islet endocrine cell mass or function ...FGF-10 signaling and induced the loss of expression of Pdx-1 [49], a ... See full document

... Luciferase assays were performed in a 96-well plate format by plating 50,000 ES cells 24 hours prior to transfection. For the Gal4 reporter assays, cells were transfected with 150 ng Gal4-luciferase reporter and 40 ng ... See full document

... canonical Wnt signaling pathway plays important roles in T cell development and activation, which may provide potential avenues for alleviating dysregulated immunity in ...of Wnt ... See full document

... autocrine signaling by tumor necrosis factor α [24, ...β signaling by c-Ski repressor was also shown to accompany this process ...30]. Wnt 8A and 5B ligand expression was also found upregulated at ... See full document

... at the same time as lung development [20]. The diaphragm is composed of the dorsomedial crural muscle, the ventrolateral costal muscle, and an amuscular central tendon [20]. The costal diaphragm is thin and ... See full document

... canonical Wnt signaling pathway in chondrogenic cells ...OA development, such that intraperitoneal administration of Dkk1 antisense oligonucleotides ameliorated chondrocyte apoptosis and cartilage ... See full document

... of Wnt/canonical pathway was identified in the development of begin and malignant breast ...of Wnt ligands and decreased activity of Wnt/Ca 2+ pathway (Howe and Brown, 2004; Clevers and Nusse, ... See full document

... -catenin signaling pathway, suggest- ing the hierarchical relationship between RAS signaling and Wnt signaling in promoting aging-related ...RAS signaling or C1q-Wnt/ β -catenin ... See full document

... tooth development. During the initiation of mouse tooth development, the expression of Wnt10a and other Wnt ligands, as well as Wnt/ β - catenin signaling activity, are mainly ... See full document

... activated Wnt signaling through accumulation of β-catenin by suppressing APC expression, leading to cell ...miR-374a/Wnt signaling path- way in PDLSCs ... See full document