[PDF] Top 20 The interaction of bovine factor VIII with human platelets
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The interaction of bovine factor VIII with human platelets
... of human platelets with purified bovine Factor VIII caused three types of aggregation: (a) primary agglutination; (b) secondary aggregation involving the platelet release reaction; and ... See full document
13
Interaction of von Willebrand factor with human platelets in the plasma milieu
... Willebrand factor (vWf) to stimulated platelets in the plasma milieu was performed using a radiolabeled monoclonal antibody to ...activated platelets but did not inhibit the ristocetin-induced vWf ... See full document
9
Infusing Factor Viii-Expressing Platelets Or Megakaryocytes As A Novel Therapeutic Strategy For Hemophilia A
... infused Factor (F) VIII ...of platelets and is capable of restoring hemostasis in FVIIInull mice, even in the presence of circulating ...with human pFVIII-expressing murine platelet. Infusion ... See full document
135
Regulation of Adamts13 Function in Hemostasis by Cofactor and Substrate Exosite interactions
... Willebrand factor (VWF) by ADAMTS13 is enhanced by clotting factor VIII ...in human embryonic kidney ...and platelets, which modulate VWF proteolysis via the A1 ... See full document
188
Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high titer inhibitory antibodies
... While gene therapy for hemophilia A has been attempted in humans, therapeutic levels of FVIII have not yet been achieved (7, 17). This failure may be attributed in part to the fact that none of these approaches directed ... See full document
10
Understanding and Improving Platelet-Delivered Factor (F) VIII Hemostatic Efficacy in Hemophilia A Mice
... functional Factor (F) ...Since platelets target to hemostatic injuries, ectopically expressed platelet (p) FVIII is an attractive alternative FVIII delivery ...platelet human B-domainless ... See full document
138
Role of human factor VIII in factor X activation
... Unactivated platelets did not support Factor X activation by Factors IXa and ...activated Factor VIII on the kinetics of bovine Factor X activation was primarily to increase the ... See full document
10
Thrombin induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
... VIIIVWF factor, by rabbit monospecific antibody against Factor VIII, and was not inhibited by an excess of fibrinogen or ...active platelets, in contrast to a system with ristocetin that ... See full document
12
Survival of 125iodine labeled Factor VIII in normals and patients with classic hemophilia Observations on the heterogeneity of human Factor VIII
... Radiolabeled human Factor VIII was used to study its survival in normals and patients with classic hemophilia, and to study the heterogeneity of Factor VIII; Purified Factor ... See full document
13
Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches?
... synthesized from the gene located on the X chromosome, it undergoes post-translational modification such as N-glyco- sylation and sulfation that are important for protein–protein interactions. Activation of FVIII is ... See full document
7
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
... to platelets can be competitively inhibited by unlabeled human or bovine FVIII/vWF, but not by human thrombin, fibrinogen, alpha 2-macroglobulin, equine collagen, or a lectin of Ricinus ... See full document
10
Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII
... nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von ... See full document
7
Role of factor VIII von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III
... from human umbilical arteries, was studied in a perfusion chamber under well defined flow ...a human albumin solution (HAS) to which purified Factor VIII-von Willebrand factor complex ... See full document
11
Molecular basis of factor VIII inhibition by human antibodies Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid
... to factor VIII have recently been shown to react with discrete regions of the factor VIII light chain (within the C2 domain) and/or the factor VIII heavy chain (within the ... See full document
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Effects of thrombin treatment of preparations of factor VIII and the Ca2+ dissociated small active fragment
... When human, canine, or bovine factor VIII preparations are chromatographed on 4% agarose at ionic strength ...the factor VIII activity elutes as a single peak in the void volume ... See full document
11
Studies on the purification and characterization of human factor VIII
... Factor VIII (antihemophilic globulin) has been prepared from Hyland method IV AHG and cryoprecipitate using limited chymotryptic digestion followed by Sepharose gel ...of factor VIII is ... See full document
12
THE SURVIVAL OF FACTOR VIII (ANTIHEMOPHILIC GLOBULIN) AND FACTOR IX (PLASMA THROMBOPLASTIN COMPONENT) IN NORMAL HUMANS
... Half-lives and standard errors of estimate of the second components of the Factor VIII survival curves in five Figure 2 shows the survival curve for Factor normal human recipients VIII i[r] ... See full document
9
Variant von Willebrand's Disease: CHARACTERIZATION OF TWO SUBTYPES BY ANALYSIS OF MULTIMERIC COMPOSITION OF FACTOR VIII/VON WILLEBRAND FACTOR IN PLASMA AND PLATELETS
... present with an average M r of 14.5 × 10 6 . Though the dimer (apparent M r = 0.48 × 10 6 ) and the monomer (apparent M r = 0.28 × 10 6 ) generated by reduction of disulfide bonds were readily identified in this system, ... See full document
9
Inhibition by human thrombomodulin of factor Xa mediated cleavage of prothrombin
... by Factor Xa in the presence of phospholipid or platelets, calcium, and Factor ...of Factor Xa and specific, saturable binding of thrombomodulin to Factor Xa ... See full document
6
Immunoradiometric measurement of the factor VIII procoagulant antigen
... A fluid-phase immunoradiometric assay has been developed which identifies an antigen on the Factor VIII (antihemophilic factor) procoagulant protein. This sensitive and quantitative assay is not ... See full document
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