[PDF] Top 20 Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A
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Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A
... IMPORTANCE Dengue virus is an important human pathogen responsible for den- gue hemorrhagic fever, whose global incidence has increased dramatically over the last several ...of dengue virus ... See full document
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Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5′ Stem-Loop of Genomic RNA
... in NS5 (K61Q in methyltransferase and W751R in ...genetic interactions among flaviviral methyltransferase, RdRp, and the 5 ⴕ stem-loop of the genomic ... See full document
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The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis
... region, stem-loop A (SLA), that serves as a promoter for NS5 polymerase binding and ...the dengue virus NS5 protein. Using mutated purified NS5 recombinant proteins ... See full document
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RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA.
... encephalitis virus (JEV) is not well ...JEV NS5 and NS3, respectively, which are proposed as components of the RNA ...putative stem-loop structure present within the plus-strand 3 * NCR was ... See full document
8
Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication
... 25% polymerase activity and the V264P mutant showed only 15% polymerase activity compared to the ...DENV3 NS5 V264 and JEV NS5 V267 lie in allowed regions of the Ramachandran ...the NS5 ... See full document
5
Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH
... of dengue virus (DENV) polymerase, nonstructural protein 5 (NS5), to accumulate within the nucleolus of infected cells and to target green fluorescent protein (GFP) to the nucleolus of live ... See full document
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Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach
... Waals interactions, hydrogen bonding, electrostatic interactions, conformational entropy, and ...of NS5 RpRd of the four serotypes of DENV were docked with two sets of compounds: molecules sharing ... See full document
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The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
... the NS5-MTase toward the ‘front’ of the polymerase, where the priming loop is situated (see Figure ...re-positioning. NS5-MTase could thus, via a direct interaction, stabilize the proper ... See full document
17
Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus
... million dengue cases occur every year, and over 40% of the world population is at risk ...severe dengue are hos- pitalized each year including a large proportion of children,” and of those, about ...of ... See full document
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Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel
... flavivirus NS5, whereas residue Thr413 is divergent among various members of ...preincubated NS5 with RNA template for 1 h before adding the inhibitor (NITD-2) and [ 3 H]GTP to initiate the reaction; under ... See full document
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Characterization of dengue virus interactions with host cells
... how dengue, a mosquito-borne Flavivirus, interacts with host cells and to characterize in vitro differences between viruses isolated before and after the emergence of DHF in Sri ... See full document
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Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene I
... (31) virus or with ...inserted between the target pro- teins and the split fluorescent segments to ensure flexibility and accessibility of each protein product within the ...putative interactions ... See full document
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Operational utility of the reverse transcription recombinase polymerase amplification for detection of dengue virus
... relationship between the number of the devia- tions from the protocol, and participant’s research experience versus the result ...accuracy between groups of participants with different research experience ... See full document
9
Structures of NS5 Methyltransferase from Zika Virus
... ZIKV NS5-MTase consists of a MTase core (residues 54–223) with a Rossmann fold, composed of seven b strands (b1–b7) and four a helices (aX, aA, aD, and aE) ( Figures 1 and S1 ...a loop (amino acids 81–86) ... See full document
7
Long-Range RNA-RNA Interactions Circularize the Dengue Virus Genome
... the dengue virus genome interact in vitro with high ...interaction between these RNA elements results in cyclization of the viral ...full-length dengue virus ...of dengue ... See full document
13
Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor
... DENV-3 polymerase/inhibitor cocrystal structure at a ...interface between the fingers and thumb subdomains (5, ...the dengue virus serotype 3 (DENV-3) RdRp were obtained at 4°C following a ... See full document
5
Interactions between dengue type 3 viruses and human dendritic cells
... require virus assembly or cell to cell ...method, virus particles have to enter cells and spread from cell to cell over a period of 5-7 ...titrating virus. One of the advantages of the FACS assay is ... See full document
156
The Crown and Stem of the V3 Loop Play Distinct Roles in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Interactions with the CCR5 Coreceptor
... ⬃10- and ⬃100-fold less efficiently than entry mediated by the wild-type JR-FL envelope glycoproteins. The LJL chimera me- diated entry into CXCR4 ⫹ cells as efficiently as wild-type gp160 LAI . JLL and JJL also mediated ... See full document
5
Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments
... in virus yield, and an absence of virus-induced CPE, but with WT-like levels of RNA replication and virus ...or virus-induced-CPE-defective NS2A mutants containing muta- tions within pTMS1, ... See full document
24
The Helical Domains of the Stem Region of Dengue Virus Envelope Protein Are Involved in both Virus Assembly and Entry
... of dengue virus (DENV) is a determinant of tropism and ...a stem region containing two amphipathic ␣-helical domains (EH1 and EH2) and a stretch of conserved sequences in ...the stem during ... See full document
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