[PDF] Top 20 <p>Interstitial Lung Disease in Systemic Sclerosis: Focus on Early Detection and Intervention</p>
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<p>Interstitial Lung Disease in Systemic Sclerosis: Focus on Early Detection and Intervention</p>
... stabilize lung function in patients with SSc- ILD in a retrospective ...that systemic disease was stabilized as measured by various assessments including FVC and that MMF was well ... See full document
25
Echocardiography may help detect pulmonary vasculopathy in the early stages of pulmonary artery hypertension associated with systemic sclerosis
... temic sclerosis from 1977 to 1980 was ...(PAH): interstitial lung disease is observed in 70% of the patients with diffused systemic sclerosis, and pulmonary hypertension in 35% ... See full document
6
Interstitial lung disease in systemic sclerosis: where do we stand?
... of lung structure for monitoring parenchymal damage [28] and a good correlation with PFTs has been shown ...in lung ultrasound (LUS) as a fast and noninvasive method with no risk of radiation exposure [26, ... See full document
9
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
... restrictive lung disease, ranging from an indolent course with stable PFT values to a rapidly progressive disease leading to respiratory failure and eventually death ... See full document
11
Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease
... to focus efforts on identifying the best sole or composite PFT surrogate marker for ...of lung physiology, disease manifestations and patient-reported outcomes ... See full document
16
Low dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study
... stopped early because of poor tolerability of imatinib (200 mg twice a day) [10], the open-label single-arm clinical trial of Spiera and col- leagues demonstrated improvement of mRSS after admin- istration of ... See full document
10
Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients
... Because most of the fibroblast characteristics obtained from SSc patients are reproduced in normal fibroblasts after stimu- lation with TGF-β1, TGF-β1 was stated as a key cytokine in SSc-associated fibrosis (reviewed in ... See full document
11
Evaluation of 99mTc rhAnnexin V 128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis
... of lung pathology compared with solid organs has inherent challenges, especially in small animals with very rapid breathing ...the detection of apoptosis in lung diseases might become possible, at ... See full document
13
Systemic sclerosis associated interstitial lung disease individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group
... derma lung study, the effect of CYC waned a few months after cessation ...bilise lung function in two studies [6, ...scleroderma lung study II on the risks and benefits of a 2-year course of MMF ... See full document
12
<p>Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease</p>
... occurs early in the course of the ...of disease, with approximately 25% of the patients developing sig- ni fi cant pulmonary involvement within 3 years of SSc ...10 Interstitial lung ... See full document
17
Immunosuppression for interstitial lung disease in systemic sclerosis
... by early diffuse SSc with high risk of progression or by limited SSc with threatening pulmonary fibrosis or pulmonary ...the lung for carbon monoxide (T LCO ) were used to evaluate pulmonary function and a ... See full document
8
Predictors of lung function decline in scleroderma related interstitial lung disease based on high resolution computed tomography: implications for cohort enrichment in systemic sclerosis–associated interstitial lung disease trials
... Systemic sclerosis–associated interstitial lung disease (SSc-ILD) is common, is associated with a poor progno- sis, and is the leading cause of death in people with SSc ...in ... See full document
10
<p>Effect of tumor necrosis factor inhibitors on interstitial lung disease in rheumatoid arthritis: angel or demon?</p>
... We acknowledge that the reported risks of TNF-I-induced ILD varied depending on the study population, control group, drug combinations, outcome indicators, and research duration. Moreover, the heterogeneity of ILD (the ... See full document
15
<p>Comparison of impedance measured by the forced oscillation technique and pulmonary functions, including static lung compliance, in obstructive and interstitial lung disease</p>
... collagen disease) were included in the ...testing, lung hyperin fl ation, decreased diffusing capacity, and ventilation unevenness in addition to air fl ow obstruc- tion in OLD, and decreased lung ... See full document
10
<p>Inhibitors of the Autotaxin-Lysophosphatidic Acid Axis and Their Potential in the Treatment of Interstitial Lung Disease: Current Perspectives</p>
... assessed in a Phase II trial for the treatment of IPF (NCT01766817). 77 This randomised, double-blind, pla- cebo-controlled trial was conducted over a period of 26 weeks, with a primary end point of rate of change in FVC ... See full document
12
Early intervention in pulmonary arterial hypertension associated with systemic sclerosis: an essential component of disease management
... of early therapeutic intervention in PAH was unequivocally demonstrated in the EARLY ...[10]. EARLY was designed to gain further insight into early stage disease and to ... See full document
7
New onset non infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden
... pulmonary disease were ...pulmonary disease for incident (2003 – 2013) and prevalent SLE ...pulmonary disease were estimated using adjusted Cox regression ... See full document
6
Computer-aided detection in chest radiography based on artificial intelligence: a survey
... classifying disease according to the ...and disease classification in the traditional CAD ...retinopathy detection [14], skin cancer classification [15], arrhythmia detection [16], and ... See full document
23
Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
... We then investigated whether SSc individuals had a skewed pattern of lymphocytes expressing chemokine- receptors involved in skin- (CCR6, CCR4 and CCR10) [10,12] and lung-homing (CCR6) [11,13,36]. CXCR3, ... See full document
9
<p>Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab</p>
... Use of belimumab IV in cSLE patients aged 5 years and older was approved by the FDA in 2019, making it the fi rst FDA-approved drug for cSLE. The Pediatric Lupus Trial of Belimumab Plus Background Standard Therapy (PLUTO) ... See full document
11
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