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[PDF] Top 20 Interventions in randomised controlled trials in surgery: issues to consider during trial design

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Interventions in randomised controlled trials in surgery: issues to consider during trial design

Interventions in randomised controlled trials in surgery: issues to consider during trial design

... a trial, it may be necessary to assess whether the intervention was delivered as intended ...the trial protocol prescribes ...error during the ...a trial taking an explanatory approach, active ... See full document

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Interventions in randomised controlled trials in surgery: issues to consider during trial design

Interventions in randomised controlled trials in surgery: issues to consider during trial design

... Surgical interventions are not usually delivered by a single surgeon working in ...the design and analysis stage [15]. Some surgical interventions may be more dependent on particular expertise than ... See full document

9

Key issues in recruitment to randomised controlled trials with very different interventions: a qualitative investigation of recruitment to the SPARE trial (CRUK/07/011)

Key issues in recruitment to randomised controlled trials with very different interventions: a qualitative investigation of recruitment to the SPARE trial (CRUK/07/011)

... of issues relevant for the future design of ...the trial by encapsulating the design in a rela- tively simple ...the trial. The SPARE study also indicated several issues relevant ... See full document

15

A concept for trial institutions focussing on randomised controlled trials in surgery

A concept for trial institutions focussing on randomised controlled trials in surgery

... been randomised and treated according to study protocols (Table ...three trials (Beger/ Bern, POVATI, PORTAS) will be available in ...key issues to be considered for organisation of CTCs and CSs ... See full document

6

A systematic review of the use of an expertise based randomised controlled trial design

A systematic review of the use of an expertise based randomised controlled trial design

... two-arm randomised controlled trial (RCT) (within-health professional) design, partici- pants are randomly allocated to one of the two interven- tions and all participating health ... See full document

10

Psychological, social, and welfare interventions for torture survivors: A systematic review and meta analysis of randomised controlled trials

Psychological, social, and welfare interventions for torture survivors: A systematic review and meta analysis of randomised controlled trials

... in trials of psychological treatment, bias arose mainly from incomplete report- ing of outcomes, dropping noncompleters from outcome analysis, and uncertainty about whether the intended treatment had been ... See full document

16

Developing a placebo controlled trial in surgery: Issues of design, acceptability and feasibility

Developing a placebo controlled trial in surgery: Issues of design, acceptability and feasibility

... An additional consideration in the risk-to-benefit ratio for participants is the nature of the proposed placebo - how “risky” the proposed placebo is perceived to be. A placebo must be able to mimic the intervention ... See full document

12

The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial

The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial

... clinical trial to be ethical regardless of whether a placebo is used or not, it must first fulfil several uni- versal requirements, for example it must be scientifically valid, be responsive to local healthcare ... See full document

5

Developing and evaluating interventions that are applicable and relevant to inpatients and those who care for them; a multiphase, pragmatic action research approach

Developing and evaluating interventions that are applicable and relevant to inpatients and those who care for them; a multiphase, pragmatic action research approach

... standard design for evidence generation, and limited prag- matic, qualitative, prognostic or observational studies to pawns in the hierarchy of evidence ...also consider studies focused to- wards relevancy ... See full document

10

Design of a randomised controlled trial of adapted physical activity during adjuvant treatment for localised breast cancer: the PASAPAS feasibility study

Design of a randomised controlled trial of adapted physical activity during adjuvant treatment for localised breast cancer: the PASAPAS feasibility study

... (ie, non-metastatic) breast cancer, the feasibility of implementing an APA intervention for 6 months, in add- ition to a dietary management, concomitant with the prescription of a fi rst line of adjuvant chemotherapy ... See full document

9

Systematic review of universal resilience interventions targeting child and adolescent mental health in the school setting: review protocol

Systematic review of universal resilience interventions targeting child and adolescent mental health in the school setting: review protocol

... be randomised (including cluster-randomised) controlled trials of universal interventions explicitly described as resilience-focussed or comprising strategies to strengthen a minimum of ... See full document

8

Evidence-based treatment for Depersonalisation-derealisation Disorder (DPRD)

Evidence-based treatment for Depersonalisation-derealisation Disorder (DPRD)

... All randomised controlled trials (RCTs) of pharmacotherapy, psychotherapy, somatic interventions and a blend of these modalities for the treatment of depersonalisation disorder were included ... See full document

13

Is perioperative goal-directed therapy able to reduce surgical complications in different surgical settings? A meta-analytic study

Is perioperative goal-directed therapy able to reduce surgical complications in different surgical settings? A meta-analytic study

... randomized controlled trial data Data abstraction included surgical risk (defined by the authors on the basis of Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity ... See full document

19

Exploring the role and function of trial steering committees: results of an expert panel meeting

Exploring the role and function of trial steering committees: results of an expert panel meeting

... single trial, meetings of the TSC should aim to be scheduled to take place 1 or 2 weeks after the DMC ...the trial risk assess- ...the trial, including for resources, for organising the meet- ings, ... See full document

14

Multiple component interventions for preventing falls and fall-related injuries among older people: systematic review and meta-analysis

Multiple component interventions for preventing falls and fall-related injuries among older people: systematic review and meta-analysis

... single interventions, such as exercise, at reducing the rate of falls in community-dwelling [4] and mixed populations ...combining interventions that are effective on their own might therefore seem ... See full document

8

A cluster randomised controlled trial to test the efficacy of facemasks in preventing respiratory viral infection among Hajj pilgrims

A cluster randomised controlled trial to test the efficacy of facemasks in preventing respiratory viral infection among Hajj pilgrims

... cluster-randomised controlled trial is being conducted to test the efficacy of standard facemasks in preventing symptomatic and proven viral RTIs among pilgrims during the Hajj season in Mina, ... See full document

9

Efficacy and acceptability of psychosocial interventions in asylum seekers and refugees: systematic review and meta-analysis

Efficacy and acceptability of psychosocial interventions in asylum seekers and refugees: systematic review and meta-analysis

... For continuous outcomes, we pooled the standardised mean differences (SMDs) as different measurement scales were used. A loose intention-to-treat analysis was applied, whereby all parti- cipants with at least one ... See full document

14

Effects of Kinesio tape on lower limb muscle strength, hop test, and vertical jump performances: a meta analysis

Effects of Kinesio tape on lower limb muscle strength, hop test, and vertical jump performances: a meta analysis

... providing SDs of WDs were calculated, and the median available inter-trial correlation coefficient was obtained. For some crossover studies in which the correlation coeffi- cient could not be calculated, the ... See full document

12

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

... Pyoderma gangrenosum (PG) is a rare inflammatory dermatosis characterised by painful and rapidly progres- sive skin ulceration [1,2]. It most commonly affects the lower limbs, but can affect any other site including the ... See full document

7

Guided, internet based, rumination focused cognitive behavioural therapy (i RFCBT) versus a no intervention control to prevent depression in high ruminating young adults, along with an adjunct assessment of the feasibility of unguided i RFCBT, in the REdu

Guided, internet based, rumination focused cognitive behavioural therapy (i RFCBT) versus a no intervention control to prevent depression in high ruminating young adults, along with an adjunct assessment of the feasibility of unguided i RFCBT, in the REducing Stress and Preventing Depression trial (RESPOND): study protocol for a phase III randomised controlled trial

... prevention trial of RFCBT, 251 students aged 15-22 with elevated worry and/or rumination (scoring on top quartiles of respective measures: ≥ 50 on Penn State Worry Questionnaire (PSWQ; [40]; ≥ 40 on Ruminative ... See full document

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