[PDF] Top 20 Investigating long noncoding RNAs using animal models

... for RNAs residing in the nucleus (78), where many lncRNAs are found ...by using RNA analogs, such as locked nucle- ic acids, which are better suited for nuclear targets because of their faster kinetics ... See full document

... mouse models have been generated independently (Eissmann et ...study using one of these KO strains has shown a retinal vascularization phenotype (Michalik et ...three models, minor effects on the ... See full document

... molecules using animal models prior to clinical applications; (3) some ncRNAs are abnormally expressed during the devel- opment and progression of various diseases, including tumors, cardiovascular ... See full document

... or r ≤ 0.9, cP value ≤ 0.01). Interestingly, more than 64% (834/1295) lncRNAs are positively coexpressed with a group of PTSGs-NMR and meanwhile exhibit negative coexpression with some other PTSGs-NMR as well, sug- ... See full document

... of noncoding RNAs, particularly microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), in the pathogenesis and regulation of the ocular ...these noncoding RNAs in the ... See full document

... antisense configuration to intron 1 of the SORL1 gene, the synthesis of which promotes the expression of alternatively spliced SORL1 variants. Notably, 51A is overexpressed in in vitro models and the AD brain. One ... See full document

... We extended our study to confirm the changes at protein level. HRECs transfected with empty vectors and H19 were treated with varying glucose concentrations (NG and HG). Following the treatments, fixed cells were ... See full document

... of MYCN by lncUSMycN seems to be dependent on a RNA binding protein NonO, whose interaction with lncUSMycN post-transcriptionally regulates MYCN expression (Figure 1). Interestingly, NonO also interacts with MYCN mRNA. ... See full document

... cancer. The decreasing cost of whole transcriptome RNA- Seq and its reciprocal increased accessibility to more labo- ratories will be instrumental in validating studies to date and addressing other questions too: What of ... See full document

... In animal cells, mitochondria are the primary powerhouses and metabolic ...encoded noncoding RNAs (ncRNAs), as well as proteins, is required. Long ncRNAs (lncRNAs) contain characteristic ... See full document

... Lung cancer is responsible for the largest number of cancer- related deaths around the world. One of the main barriers to the success of lung cancer therapy is the lack of tumor biomarkers for early diagnosis. In the ... See full document

... expressed long noncoding RNAs (lncRNAs) in pulmonary adenocarcinoma tissue and adjacent noncancerous tissue from Chinese patients using lncRNA expression microarray and preliminary ... See full document

... Long noncoding RNA (lncRNA) is a leader of the degree of more than 200 nucleotides, almost do not have the function of protein coding endogenous RNA ... See full document

... The sample preparation and microarray hybridization were performed based on the Arraystar’s standard protocols. Labeled cRNAs were hybridized onto the Arraystar Human circRNA Array (8 × 15 K, Arraystar). Subsequently, ... See full document

... Microarray of lncRNAs was performed by Beijing CapitalBio Technology Co., Ltd (Beijing, People’s Republic of China). lncRNAs from all canonical databases, NCBI Refseq, UCSC Known Gene, NRED, and RNAdb, were covered with ... See full document

... ABSTRACT Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia, affecting infants and adults world- wide. N. meningitidis is also a common inhabitant of the human nasopharynx and, as such, is ... See full document

... Long noncoding RNAs (lncRNAs) have been detected in nearly every cell type and found to be fundamentally involved in many biological processes. The characterization of lncRNAs has immense potential ... See full document

... regulatory RNAs integrate signals from both genetic and environmental fac- tors, and therefore can play major roles in controlling bio- logical processes ...with long intergenic non-coding RNAs ... See full document

... LncRNAs exert important roles in myeloid differ- entiation and can respond to differentiation induc- tion therapy. At present, two lncRNAs, HOTAIRM1 and NEAT1 are known to regulate the differentiation of AML cells. ... See full document

... The mutations occurring in DMD patients could also deregulate the expression of lncRNAs located outside the dystrophin gene or could even give rise to new lncRNAs as a result of translocation events. This could modulate ... See full document