[PDF] Top 20 Involvement of Influenza Virus PA Subunit in Assembly of Functional RNA Polymerase Complexes
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Involvement of Influenza Virus PA Subunit in Assembly of Functional RNA Polymerase Complexes
... ts53 PA caused temperature-sensitive expression (data not ...wild-type PA and ts53 PA, ts53 PA did not efficiently inhibit the function of wild-type PA, but an excess amount of ts53 ... See full document
Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II
... that influenza virus transcription has a functional link with Pol II transcription ...enza virus RNA polymerase is indeed associated with Pol ...large subunit of Pol II ... See full document
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Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
... vaccinia virus encoding T7 RNA ...reconstitute RNA polymerase activity in vivo by cotransfection with proteins NP, PB1, and PA and a virion-like RNA encoding the cat gene into ... See full document
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PA Subunit from Influenza Virus Polymerase Complex Interacts with a Cellular Protein with Homology to a Family of Transcriptional Activators
... hCLE-PA subunit interaction. In the case of influenza virus, it has been shown that cellular factors are involved in the modulation of the influenza virus RNA synthe- sis ... See full document
8
Nuclear Import and Assembly of Influenza A Virus RNA Polymerase Studied in Live Cells by Fluorescence Cross-Correlation Spectroscopy
... strand RNA segments (2). In contrast to many RNA viruses, the influenza virus genome is transcribed and replicated by the trimeric viral RNA polymerase (PA, PB1, and PB2) ... See full document
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Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers
... the polymerase subunits PB1, PB2, and PA (28, ...one subunit of the polymerase or NP with that from a human ...reduced polymerase activity, regardless of whether PB1 was derived from ... See full document
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Functional Analysis of PA Binding by Influenza A Virus PB1: Effects on Polymerase Activity and Viral Infectivity
... A virus expresses three viral polymerase (P) subunits—PB1, PB2, and PA—all of which are essential for RNA and viral ...viral RNA transcription and ...heterotrimer subunit inter- ... See full document
10
In Vitro Assembly of PB2 with a PB1-PA Dimer Supports a New Model of Assembly of Influenza A Virus Polymerase Subunits into a Functional Trimeric Complex
... PB1 subunit requires the coexpression of PA for efficient transport from the cytosol to the nucleus, while the PB2 monomer can accumulate in the nucleus on its own ...that influenza virus ... See full document
6
Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT
... the assembly and nuclear import of the RNA polymerase has also been suggested ...ribonucleoprotein complexes as in panel ...C. RNA levels in siRNA-treated cells were expressed as a ... See full document
9
Role of Ran Binding Protein 5 in Nuclear Import and Assembly of the Influenza Virus RNA Polymerase Complex
... in RNA polymerase nuclear ...and PA in 293T cells treated with RanBP5-specific ...that PA is required for the nuclear accu- mulation of PB1 ...on RNA polymerase ...and PA ... See full document
9
Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation
... A virus is an orthomyxovirus and an important patho- gen of humans and ...single-stranded RNA which are encap- sidated as viral ribonucleoprotein complexes (vRNPs) by multiple copies of nucleoprotein ... See full document
14
Structural and Functional Characterization of an Influenza Virus RNA Polymerase-Genomic RNA Complex
... or PA-containing heterodimers, were analyzed by chromatography over 7methyl-GTP-Sepharose, using Sepha- rose as the negative ...using subunit-specific antibodies and is presented in ...and PA ... See full document
11
Amino Acid Residues in the N-Terminal Region of the PA Subunit of Influenza A Virus RNA Polymerase Play a Critical Role in Protein Stability, Endonuclease Activity, Cap Binding, and Virion RNA Promoter Binding
... inhibited polymerase activity severely ...these PA mutants ...the functional assembly of the trimeric complex of PB1, PB2, and PA, a TAP-tagged PB2 polymerase complex was ... See full document
10
Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice
... Influenza virus transcription requires functional coupling with cellular transcription for the cap-snatching ...fact, RNA polymerase II (RNAP II) is degraded during infection in a ... See full document
9
Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase
... tended PA linker occupies the ...the polymerase activities of R279A, K281A, and K289A were significantly ...the influenza virus polymerase complex using TAP pulldown of the ... See full document
10
Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase
... A virus (FluA) and influenza B virus (FluB) be- long to the family of ...of RNA (vRNA) of negative ...the RNA polymerase to form viral ribonucleoprotein (vRNP) ...the RNA ... See full document
9
HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit
... IAV polymerase function (27); phosphorylation of IAV NS1 impairs its interferon- antagonistic activity (28), and phosphorylation of M1 is crucial for its nuclear import (29); the acetylation of IAV HA is essential ... See full document
13
Involvement of Hsp90 in Assembly and Nuclear Import of Influenza Virus RNA Polymerase Subunits
... viral polymerase subcomplexes is required for the assembly of active polymerase ...mutant virus containing mutations in the PA ...form functional ternary polymerase com- ... See full document
11
Defective Assembly of Influenza A Virus due to a Mutation in the Polymerase Subunit PA
... The RNA-dependent RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments ... See full document
10
A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs
... mutant PA proteins. To test the func- tionality of the mutant PA proteins, we used an in vivo tran- scription-replication assay based on in vivo reconstitution of viral RNP complexes and expression ... See full document
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