[PDF] Top 20 Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
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Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
... HCV RNA replication ele- ment is positioned within the coding region, whereas, until recently, all other elements known resided within the ...the RNA template, which in turn would affect RNA ... See full document
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Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
... plus-strand RNA viruses, sequences at the 3⬘ end of the genome were shown to play crucial roles in RNA ...the 3⬘ NTR of GB virus B, a virus that is very closely ... See full document
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Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious Virus
... HCV RNA and results in decreased rates of decay of both synthetic viral RNA transfected into cells and replicating viral RNA in infected cells ...whether 3= supplementary base pair interac- ... See full document
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Structure of the 3' terminus of the hepatitis C virus genome.
... Hepatitis C virus (HCV), a major causative agent of non-A, non-B viral hepatitis, has about ...positive-stranded RNA genome with remarkable sequence diversity among in- dividual ... See full document
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A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... served RNA secondary structures in coding regions has been analyzed extensively by reverse genetic analysis, predominantly using antibiotic resistance or a luciferase-encoding subgenomic replicon system (18), and ... See full document
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HMGB1 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 4 in the Viral 5′ Untranslated Region
... an essential role in TLR signaling activation, including TLR3, TLR7, and TLR9 pathways ...HCV RNA (16, 52). NF90 is involved in the replication process of several positive- strand RNA viruses ... See full document
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RNA-protein interactions at the 3' end of the hepatitis A virus RNA.
... the RNA-protein interaction, the results of competition of various homo- and heteropolymeric polynucleotides as well as antisense probes with 3 9 end tran- scripts were ...the ... See full document
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Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA.
... predictions. RNA folding programs mfold (19) and FoldRNA (Genetics Computer Group pack- age) were used to predict thermodynamically favored second- ary structures for the HCV 3 9 ...NTR. RNA folding ... See full document
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Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication
... are essential for RNA ...5⬘ end of a viral RNA genome are very important determinants for replication, we anticipated that the same might be true for ...for RNA ... See full document
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Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA.
... other RNA viruses, conserved sequences or structures at the termini of viral RNAs often modulate translation, replica- tion, and/or packaging via interactions with protein(s) and/or other RNA elements ... See full document
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Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... Hepatitis C virus (HCV) is now recognized as the principal agent of parenterally transmitted non-A, non-B ...viral genome has been cloned and sequenced (5) and shown to be a ...positive-sense ... See full document
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DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... double-stranded RNA and separate the RNA strands or might contribute to the function of HCV NS3 ...the replication of subgenomic replicon RNA was also partially suppressed in DDX3 knockdown ... See full document
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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
... viral RNA genome into the nucleocapsid may require distinct RNA structures, which are often located near the 5 ⬘ end of the RNA genome or at some other position within the viral ... See full document
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Involvement of Creatine Kinase B in Hepatitis C Virus Genome Replication through Interaction with the Viral NS4A Protein
... HCV RNA replication through CKB via its in- teraction with NS4A, we first investigated whether CKB mod- ulates NS3-4A helicase ...unwinds RNA-RNA substrates in a 3 ⬘ -to-5 ⬘ direction. ... See full document
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Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... at 3 and 6 h ...at 3 and 6 h ...of RNA translation by mutations introduced into the 5⬘-proximal stem-loop RNA ...stem-loop RNA element is also important for opti- mal ... See full document
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Evaluation of canonical siRNA and Dicer substrate RNA for inhibition of hepatitis C virus genome replication - a comparative study
... this end, SGR-Feo-JFH-1 cells were transfected with 5 nM of either DsiRNA1 or DsiRNA5 (NS5B or NS4B) and their 21 nt corresponding (siD1 or siD5) and treated with G418 for up to 21 ...days. RNA was ... See full document
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A hepatitis C virus cis acting replication element forms a long range RNA RNA interaction with upstream RNA sequences in NS5B
... Substitution of the CRE with the analogous region of different genotypes of HCV produced replicons with phenotypes consistent with the hypothesis that both local and long-range interactions are critical for a fundamental ... See full document
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Specific Interaction between the Hepatitis C Virus NS5B RNA Polymerase and the 3′ End of the Viral RNA
... HCV replication have been restricted by the lack of a well-estab- lished cell culture system, but studies from other positive-sense RNA viruses may provide some ...genomic RNA occurs, and ... See full document
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The Nucleotides on the Stem-Loop RNA Structure in the Junction Region of the Hepatitis E Virus Genome Are Critical for Virus Replication
... E virus (HEV) is the causative agent of hepatitis E, and at least four major genotypes have been recognized in mammalian species: genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 ... See full document
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A bulged stem-loop structure in the 3' untranslated region of the genome of the coronavirus mouse hepatitis virus is essential for replication.
... an essential RNA second- ary structure at the 5 9 end of the MHV 3 9 UTR, which was discovered through our initial unsuccessful efforts to substitute a nonhomologously spliced segment of the ... See full document
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