[PDF] Top 20 Localization of the gD-Binding Region of the Human Herpes Simplex Virus Receptor, HveA
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Localization of the gD-Binding Region of the Human Herpes Simplex Virus Receptor, HveA
... of gD-1(306t) binding to ...of HveA were directly coupled to flow cell 2 (Fc2) of a CM5 research-grade chip (Biacore AB) at pH 5 as previously described (29, ...gD1(306t) binding to ... See full document
10
The Major Neutralizing Antigenic Site on Herpes Simplex Virus Glycoprotein D Overlaps a Receptor-Binding Domain
... of gD was constructed such that six histidine residues were present at the C terminus to allow for purification by nickel ...The gD truncation mu- tants were purified by immunoaffinity chromatography ... See full document
12
Herpes B virus gD interaction with its human receptor - an in silico analysis approach
... BV gD-receptor complexes were constructed using homology modelling and docking ...BV gD receptor interaction patterns were ...BV gD and nectin-1 molecule is not geometrically ...main ... See full document
16
Displacement of the C Terminus of Herpes Simplex Virus gD Is Sufficient To Expose the Fusion-Activating Interfaces on gD
... binds gD and blocks receptor binding ...when virus was selected on a lineage of BHK (TK ⫺ ) cells that do not express HSV receptor ...the receptor binding interface, in a ... See full document
11
HveA (Herpesvirus Entry Mediator A), a Coreceptor for Herpes Simplex Virus Entry, also Participates in Virus-Induced Cell Fusion
... events: binding and ...gB, gD, and the hetero-oligomer ...bind virus but restrict entry (36, 43, 49). Expression of the human cell surface glycoprotein HveA (herpesvirus en- try ... See full document
9
Crystal Structure of Herpes Simplex Virus 2 gD Bound to Nectin-1 Reveals a Conserved Mode of Receptor Recognition
... Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human ...(gD), human nectin-1 as a functional ...the binding between HSV-1 gD and nectin-1 by ... See full document
11
Herpes Simplex Virus with Highly Reduced gD Levels Can Efficiently Enter and Spread between Human Keratinocytes
... of herpes simplex virus type 1 (HSV-1) in mucosal epithelia and neuronal tissue depends primarily on the ability of the virus to navigate within polarized cells and the tissues they ...of ... See full document
10
The C Terminus of the B5 Receptor for Herpes Simplex Virus Contains a Functional Region Important for Infection
... characterized human gene designated human fe- tal lung cDNA B5 (hfl-B5) (32a) is expressed in a wide range of tissues and encodes a 43-kDa gene product (B5) that me- diates HSV ...known human ... See full document
7
The soluble amino terminal region of HVEM mediates efficient herpes simplex virus type 1 infection of gD receptor negative cells
... the herpes simplex virus type 1 (HSV-1) entry receptor nectin-1 can both block HSV infection of receptor-bearing cells and mediate infection of receptor-deficient ...entry ... See full document
10
Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells
... individual virus life ...different virus groups and genetic and biochemical studies that define recep- tor-ligand interactions provide information essential to devis- ing strategies for altering ... See full document
15
Chimeric Nectin1-Poliovirus Receptor Molecules Identify a Nectin1 Region Functional in Herpes Simplex Virus Entry
... the binding to ...HSV gD is nonexistent but high enough to ...with gD(⌬290-299t) followed by anti-gD MAb ...R1.302. gD-binding analysis: dashed line, negative control consisting ... See full document
8
Differential Effects on Cell Fusion Activity of Mutations in Herpes Simplex Virus 1 Glycoprotein B (gB) Dependent on Whether a gD Receptor or a gB Receptor Is Overexpressed
... N-terminal region and the disordered region near the middle of the ectodomain ...the binding of PILR ␣ to gB, as to CD99, requires two sialylated O-glycans, perhaps located at widely separated ... See full document
7
Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD
... of gD, free (34) or bound to either HVEM (35) or nectin-1 (36, 37), showed that binding of either receptor requires movement of the C-terminal portion of the gD ...that gD plays two ... See full document
15
Substitution in the Murine Nectin1 Receptor of a Single Conserved Amino Acid at a Position Distal from the Herpes Simplex Virus gD Binding Site Confers High-Affinity Binding to gD
... its human nectin1 counterpart, murine nectin1 serves as a cellular receptor for the entry of herpes simplex virus (HSV) into murine ...either receptor is dependent on the viral ... See full document
9
Structure-Based Analysis of the Herpes Simplex Virus Glycoprotein D Binding Site Present on Herpesvirus Entry Mediator HveA (HVEM)
... the HveA mutants mediate entry of HSV Rid1? HSV Rid1 is a virus with a single amino acid mutation in gD ...This virus is unable to use human HveA for entry, and gD from ... See full document
11
Engineered Disulfide Bonds in Herpes Simplex Virus Type 1 gD Separate Receptor Binding from Fusion Initiation and Viral Entry
... allow gD function: residues 286 to 306 for binding and residues at or before residue 279 for ...of gD crystal structures, and residues 256 to 268, due to their flexibility, have not been resolved in ... See full document
10
Inhibition of Herpes Simplex Virus gD and Lymphotoxin-α Binding to HveA by Peptide Antagonists
... of gD-1 binding to ...the binding of gD-1 to the HveA receptor ...wild-type gD-1, gD-1(306t), to immobilized HveA(200t) was reduced by BP-2 to a level of 80% ... See full document
7
Antibody-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein gD Reveal New Targets for Virus Neutralization
... block receptor bind- ing. Interference with receptor binding is a common mechanism by which antibodies block virus infection (49, ...neutralizing human MAbs against severe acute ... See full document
14
Identification of a Region of the Herpes Simplex Virus Single-Stranded DNA-Binding Protein Involved in Cooperative Binding
... a region of the herpes simplex virus major DNA-binding protein (ICP8) which is involved in cooperative binding to single-stranded ...The binding properties of the modified ... See full document
9
Cytoplasmic Residues of Herpes Simplex Virus Glycoprotein gE Required for Secondary Envelopment and Binding of Tegument Proteins VP22 and UL11 to gE and gD
... UL11 binding to the gE CT domain with pull-down experiments involving HSV- infected cells expressing gE truncations immunoprecipitated with anti-gE MAb and blotted with anti-VP22 or anti-UL11 ...VP22 ... See full document
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