[PDF] Top 20 Longitudinal Study of Gray Matter Changes in Parkinson Disease

... present study had a shorter follow-up period (mean, 12 months) at an earlier disease stage (mean Hoehn and Yahr stage, ...that study (mean follow-up period, 25 months; mean Hoehn and Yahr stage, ... See full document

... degenerative disease such as PD and may therefore overestimate their ...our study include the following: one of the largest prospective studies to examine PD-ICB; the adoption of a dimensional compared with ... See full document

... PADDINGTON study [11] across four study sites (Leiden, Netherlands; London, UK; Paris, France; Ulm, ...separate study visits, with an initial baseline and subsequent 6-month and 15-month ...the ... See full document

... can study the changes of brain structure on the human body, and the main research methods are ROI method and VBM ...The study of brain structure is moving forward with the use of VBM ... See full document

... ABBREVIATIONS: DPD ⫽ depressed PD; DSM ⫽ Diagnostic and Statistical Manual of Mental Disorders; DTI ⫽ diffusion tensor imaging; FA ⫽ fractional anisotropy; fMRI ⫽ functional MR imaging; FMRIB ⫽ Functional MR Imaging of ... See full document

... this study was to assess microstructural changes in gray and white matter with diffusional kurtosis imaging in the acute, delayed neuropsychiatric, and chronic phases after acute carbon ... See full document

... However, because it is often impossible to date the biologic or subclinical onset of MS that, in adult patients, may precede its clinical onset by some months to several years, the assess- ment of how early GM atrophy ... See full document

... MATERIALS AND METHODS: Our sample included patients with PD without dementia (n ⫽ 10; Hoehn and Yahr stages I and II; Unified Parkinson Disease Rating Scale, 20.5 ⫾ 8.3; and Mini-Mental State Examination, ... See full document

... logic study, García-Campayo et al found that the somatic symptoms are strongly associated with the severity of depres- sion, quality of life (QOL), as well as health resources ...system disease such as ... See full document

... of gray and white matter throughout the whole brain, there has been considerable variation in terms of volume changes among the published studies, probably due to small and heterogeneous samples of ... See full document

... observed changes in metabolite ...the study, the time point where SNR is determined to be best, we added extra noise into the raw data in the time domain using software coded using Matlab7 (Matlab, The ... See full document

... cortical gray matter but not total brain. Our finding of reduced total gray matter with similar subcortical volumes supports a spe- cific reduction in cortical volumes, while the similar total ... See full document

... the gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) tissue prob- ability maps as provided in the toolbox; (d) GM images were non-linearly normalized to the template space and were ... See full document

... structural changes occur in early disease stages, before clinical manifes- tations become ...a disease that is restricted to the nigrostriatal pathway but may involve structures beyond this pathway, ... See full document

... To correlate GM volume changes and FOG-Q score, we per- formed a correlation analysis by using the multiple regression func- tion of SPM8. Correlation analyses were performed inside and outside specific ROIs. We ... See full document

... Gray matter lesions have been underestimated by visual inspection of conventional MR pulse se- quences because of a lack of conspicuity between lesions (high intensity) and ...deep gray matter ... See full document

... population‑based prospective study reported increased risk of PD in patients with EDS. This risk persists after controlling for various confounders like mid‑life cigarette smoking and coffee drinking, bowel ... See full document

... white matter is involved with lesions identical to those of other slow virus infections of the brain, such as subacute AIDS ...progressing disease showed signs of acute white matter inflammation with ... See full document

... this study all experiments conducted on animals were in accordance with the guidance of the ethical committee for research on laboratory animals of Shiraz ... See full document

... in gray mat- ter (GM) and in white matter (WM) at 300-mm intervals along longitudinal 30-mm sagittal sec- tions of spinal cord (T8–T9; n = 6–8 per ...white matter of an MG (IL-4) -treated ... See full document