[PDF] Top 20 Meta analysis of randomized phase II trials to inform subsequent phase III decisions

... a meta-analysis of Phase II randomized trials, as motivated by a real example in acute myocar- dial infarction ...how Phase II meta-analysis results ... See full document

... subgroup analysis might be carried out in the future to obtain a deeper insight with further ...subgroup analysis with vinca alkaloid, docetaxel enhanced PFS and ORR signifi- cantly and increased OS to some ... See full document

... 10 randomized placebo-controlled phase III clinical trials of DPP-4 inhibitors conducted in patients with T2DM in China, NCT01076088 [12] and NCT01289119 [17] have 3 placebo controlled groups ... See full document

... (1999). Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: Gynecologic ... See full document

... reviewed trials and abstracts of potentially eligible studies and extracted information from studies that met the inclusion criteria, including authors, publication year, sample size, patient characteristics, ... See full document

... the trials is shown in Figure ...four trials reported overall response rates, com- plete rates, progression-free survival, overall survival as well as ...three trials compared LD with placebo plus ... See full document

... were randomized control trials, or clinical trials in phase II or III with more than 30 subjects; (ii) all the subjects were adults who were diagnosed with glioma, ... See full document

... current meta-analysis, should be underlined that in all 3 studies, differently from randomized studies in the first-line setting in which no global OS benefit was found [1–2], bevacizumab was ... See full document

... prospective Phase II or III randomized controlled trials on checkpoint inhibitors for patients with unresectable cutaneous melanoma that reported data on survival (overall or ... See full document

... Phase II RCTs evaluating the efficacy of olaparib in ovar- ian cancer were analyzed in that ...this meta-analysis to investigate the role of olaparib in cancer ... See full document

... a meta-analysis of Phase III randomized controlled trials was ...Controlled Trials. After evaluation of quality, a meta-analysis of valid extracted data was ... See full document

... our meta-analysis. First, this is a meta-analysis at study level, not on the patients’ data, therefore confound- ing variables at the patient level, such as previous treatment exposure and ... See full document

... and meta-analyses could incorporate a PRECIS score for synthesized trials and help the system- atic mapping of the pragmatism in published ...systematic analysis in trials of acupuncture for ... See full document

... antisecretory effect of octreotide was higher than that of other anticholinergic drugs (hyoscine). According to clinical trial data, the combination of octreotide plus dopamine antagonist significantly increased the rate ... See full document

... Clinical trials have reported conflicting results about the efficacy and toxicity of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for treating metastatic breast ...This meta-analysis was ... See full document

... treatment decisions, potential efficacy and pre-exist- ing resistance primarily influence the selection of a cART regimen ...large Phase III RESIST trials at 48 weeks ... See full document

... in the prevention of hip and other nonvertebral fractures remains uncertain. Thus, the benefits of these compounds in reducing the risks of fracture and invasive breast cancer should be weighed against the increased ... See full document

... a higher percentage of ramucirumab patients (n = 204 [33%]) compared with control patients (n = 139 [23%]). The most common ADRs resulting in dose adjustments were neutrope- nia (n = 77 [12%] ramucirumab vs n = 55 [9%] ... See full document

... The results reported here should be interpreted after considering the limitations of the current analysis. In addition to the inherent limitations of a post hoc anal- ysis, this study included short-term data ... See full document

... clinical trials on chemovirotherapy are based on a plethora of encouraging results from numerous preclinical models and are obtained mostly by systematic approaches in which key features such as the order of ... See full document