[PDF] Top 20 Metabolic changes in cancer cells upon suppression of MYC
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Metabolic changes in cancer cells upon suppression of MYC
... in MYC-dependent osteogenic sarcoma cells MYC-dependent osteogenic sarcoma cells displayed a slight elevation in glucose consumption and lactate pro- duction compared with osteocytes (Figure ... See full document
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Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation
... three MYC family genes together, even though only one of them is amplified [14], imply the convenience of a common suppressing agent to all MYC proteins, MYC, MYCL and MYCN, to inhibit the growth of ... See full document
15
Blockade of telomerase reverse transcriptase enhances chemo sensitivity in head and neck cancers through inhibition of AKT/ ERK signaling pathways
... mouse cells, respectively ...tumor suppression and obtained oncogenic function in cancer cells, it still retained the ability to drive apoptosis when receiving death ...protect cells ... See full document
14
The role of c-Myc-RBM38 loop in the growth suppression in breast cancer
... breast cancer tissues compared to that in normal breast tissues, where it acts as a tumor suppres- sor ...breast cancer cells, whereas levels were increased by RBM38 ...c- Myc transcripts by ... See full document
11
PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway
... of cancer, including ovarian ...the metabolic shift of ovarian cancer ...ovarian cancer tissue. In addition, PTTG suppression by specific shRNA could inhibit the proliferation of ... See full document
11
Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl 2 proteins as novel therapeutic targets for cancer
... uated cancer cell proliferation and apoptosis [27, 30]. Myc oncogene, which is activated in many cancers, is known to regulate the transcription of several cellular proliferation- related genes and ... See full document
7
c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer
... expression changes of c-Myc as a function of time in hypoxia, colon cancer cells (HCT116 and SW480) were cultured in normoxic (21% O 2 ) or hypoxic (1% O 2 ) conditions for ...HCT116 ... See full document
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Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile
... temperature, cells were applied to a Muse Cell Analyzer (Merck ...of cells and of conditioned medium were obtained 96 h after administration of ...methanol. Cells were harvested after addi- tion of ... See full document
12
NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
... In the present study, we determined the roles of NPM1 in pancreatic ductal adenocarcinoma (PDAC) aerobic glycolysis and of NPM1-FBP1 axis in pancreatic tumorigenesis. The results showed a critical role for NPM1 in ... See full document
9
Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells
... the metabolic response to methionine stress in the triple negative breast cancer cell line MDA-MB-468 and its methionine insensitive derivative cell line ...a metabolic down-regulation of oxidative ... See full document
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Effectiveness of a Computer Based Syntax Program in Improving the Morphosyntax of Students Who are Deaf/Hard of Hearing
... regulating metabolic enzymes activities, such as Ras, Akt and Myc (Gordan, Thompson et ...why cancer cells prefer to glycolysis for Warburg ... See full document
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Adenosine-to-inosine RNA editing and human disease
... [1]. Changes in ADAR activity, caused by mutations or changes in expression, have been associated with a wide range of human diseases, including cancer, neurological disorders, metabolic ... See full document
13
Dickkopf 1 is regulated by the mevalonate pathway in breast cancer
... breast cancer cells after 24 hours of treatment with zoledronic ...prostate cancer cells. PC3 cells treated with zoledronic acid (100 μ M) or atorvastatin (10 μ M) for 24 ...endothelial ... See full document
13
Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II.
... N-myc2-induced cell death is blocked by bcl-2 but not by WHV X-gene expression. If N-myc2 up-regulation induces an apoptotic signal in hepatocytes, then some means of counter- acting or negating this signal must be ... See full document
9
Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells
... breast cancer brain metastases and WP1066 inhibited brain ...BT-474 cells. (B) Expression levels of pStat3 in 90 IDC and 89 breast cancer brain metastasis ...MDA-MB-231BR cells and BT-474BR ... See full document
14
FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma
... SW1990 cells were infected with lentivirus expressing control, FBP1- specific ...infection, cells were harvested for western blot analysis (a) and RT-qPCR ...PANC-1 cells cells were infected ... See full document
12
PVT1 MYC expression through real time PCR in plasma cells purified from 59
... 7. Djebali, S.; Davis, C.A.; Merkel, A.; Dobin, A.; Lassmann, T.; Mortazavi, A.; Tanzer, A.; Lagarde, J.; Lin, W.; Schlesinger, F.; Xue, C.; Marinov, G.K.; Khatun, J.; Williams, B.A.; Zaleski, C.; Rozowsky, J.; Röder, ... See full document
14
Cytotoxic activity of acnistins upon human cancer cells
... melanoma cells was greater than against the other cell ...melanoma cells showed antagonism between these compounds, a fact which could give some insight into the mechanism of action of the ... See full document
11
MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation
... The oncoprotein c-Myc is essential for cell growth and proliferation while its deregulated overexpression is associated with most human cancers. Thus tightly regulated levels and activity of c-Myc are ... See full document
14
G-Quadruplex Targeting Ligands: a Hope and a New Horizon in Cancer Therapeutics
... connections were extremely steady as experimented from Molecular Dynamics Simulation. They protected the G-quartet proximal to 5′-terminus by gripping the backbone of the guanines delineating the quartet. Furthermore, ... See full document
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