[PDF] Top 20 Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer
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Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer
... the metabolic analysis of peripheral CTCs in PCa ...stage, cancer metastasis and serum tPSA level, although they made up only a small part of the total ...with tumor stage and tPSA ...advanced ... See full document
15
TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer
... Circulating tumor cells (CTCs) are important for metastasis in prostate ...parental cells. TOPK is more highly expressed in the CTCs than in parental cells and is also highly ... See full document
13
Circulating tumor cells capture disease evolution in advanced prostate cancer
... “Prostate Cancer Sample Collection” pro- tocol of the University of Chicago Medical Center, which was approved by the University of Chicago ethics com- mittee (approval reference number ...expression. ... See full document
8
Quantitative characterization of androgen receptor protein expression and cellular localization in circulating tumor cells from patients with metastatic castration resistant prostate cancer
... Circulating tumor cells (CTCs) are emerging as a source of therapy-resistant prostate cancer material, a so-called “liquid biopsy” that could serve as a therapeutic biomarker ...examine ... See full document
15
Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer
... of circulating tumor cells (CTCs) in peripheral blood correlates with clinical outcome in castration-resistant prostate cancer ...to prostate cancer ...in prostate ... See full document
13
Exploring Markov modeling approaches for the health economic assessment of circulating tumor cells in the management of metastatic prostate cancer patients
... (metastatic) prostate cancer; mCRPC; circulating tumor cells; CTC; CTC trap; Circulating Tumor Cells therapeutic aphaeresis; therapy monitoring; management; medical ... See full document
28
Detection of Circulating Tumor Cells in Prostate Cancer Patients: Methodological Pitfalls and Clinical Relevance
... all cells of the body, includ- ing ...for prostate cancer PCR studies include ACTb and ...differentiated prostate can- cer subclones may not express the tissue-specific gene, a situation that ... See full document
14
Clinical and Experimental Importance of Circulating Tumor Cells in Prostate Cancer
... apoptotic cells represent a favourable prognosis for patients? In the study by Rossi et ...breast cancer patients using the integrated M-30 assay on the CSS (2µg/mL and exposure time ... See full document
286
Circulating tumor cells correlate with patterns of recurrence in patients with hormone-sensitive prostate cancer
... 20 mL of whole blood was drawn into two proprietary CellSave tubes (Veridex). CTC positivity was defined as $5 CTCs/7.5 mL. After immunomagnetic capture, the CTCs were labeled with a fluorescent nucleic acid dye, 4 ′ ... See full document
5
Tumorigenic potential of circulating prostate tumor cells
... Circulating tumor cells (CTCs) have received intense scientific scrutiny because they travel in the bloodstream and are therefore well situated to mediate hematogenous ...non-viable cells, ... See full document
9
Detection of Circulating Tumor Cells in Patients with Breast, Prostate, Pancreatic, Colon and Melanoma Cancer: A Blinded Comparative Study Using Healthy Donors
... The cancer types and stages of the samples used include: Breast cancer, two patients with stage I, two patients with stage II, four patients with stage III and two patients with stage IV; prostate ... See full document
11
Original Article Morphological and gene-expression characterization of viable heterogeneous circulating tumor cells size-captured and cultured from triple-negative breast cancer mouse models
... In a subsequent study, using immunomagnetic beads, CTCs were rapidly isolated from the cir- culation of mice orthotopically implanted with human PC-3-GFP prostate cancer cells. The PC-3-GFP CTCs were ... See full document
8
Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
... of prostate cancer (PCa) in the United States and over 300,000 globally every year (1, ...sensitive cells die off, and an adaptation process, in which stromal and epithelial cells coevolve to ... See full document
14
Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl 2 proteins as novel therapeutic targets for cancer
... uated cancer cell proliferation and apoptosis [27, ...Many cancer cells convert signifi- cant proportion of glucose to lactate, thus producing an acidic microenvironment surrounding the cancerous ... See full document
7
Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection
... of cancer. Based on the “seed and soil” theory, a small portion of CTCs ...monitor cancer progression ...breast, prostate, colon, melanoma, and lung cancer [4, ...early cancer ... See full document
23
Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment
... An IDO enzymatic activity was performed using a protocol adapted from previously described methods [53, 54]. Murine samples used in the IDO activity assays were prepared in Dulbecco’s Phosphate Buffered Saline (DPBS) ... See full document
18
PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
... cell scrapers. The detailed metabolite extraction can be referred to [47]. We investigated the change of metabolites and metabolism pathway using gas chromatography with time-of-flight mass spectrometry ... See full document
16
Health economic impact of liquid biopsies in cancer management.
... of tumor cells in blood was first observed in 1869 (10); a validated assay for reliable CTC measurement was introduced in 2004 (11) and results from multicenter prospective studies in metastatic breast and ... See full document
24
Search | Preprints
... of cancer-related deaths [1]. To enable successful metastasis, cancer cells often engage a trans-differentiation program referred to as epithelial-mesenchymal transition (EMT) in order to promote ... See full document
50
Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor
... is based on fully understanding cancer initiation, progression, metastasis, subclonal switch for dormant cells, and evolving drug targets, which we know little about at the ...velop cancer, ... See full document
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