[PDF] Top 20 Mitophagy dependent necroptosis contributes to the pathogenesis of COPD
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Mitophagy dependent necroptosis contributes to the pathogenesis of COPD
... acid–induced necroptosis (57). An emerging hypothesis, therefore, is that mitophagy also contributes to cell death in a con- text-specific ...required mitophagy, involving LC3-ceramide ... See full document
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<p>Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis</p>
... the pathogenesis of COPD, and furthermore, both genes were downregulated in severe COPD; therefore, the present study sort to investigate the role of the SLIT2-ROBO pathway in all disease stages of ... See full document
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<p>Innate Immunity and Cell Surface Receptors in the Pathogenesis of COPD: Insights from Mouse Smoking Models</p>
... in COPD pathogenesis; however, some experimental evi- dence supports a role of acquired responses that requires the proliferation of T cells as central regulators of the in fl ammatory ...in COPD may ... See full document
12
Novel aspects of pathogenesis and regeneration mechanisms in COPD
... help us understand the pathogenesis of COPD exacerbations and disease progression in general. We still need to know what normal and abnormal lung microbiota are and if it is possible to repopulate diseased ... See full document
19
Akt in the pathogenesis of COPD
... unknown, COPD is only marginally responsive to all contemporary drugs, even powerful antiinflammatory glucocorticosteroids (Keatings et al 1997; Barnes ...2000). COPD is diverse and encompasses emphysema, ... See full document
8
Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
... severe COPD patients in comparison to healthy controls ...of COPD remain ...in COPD patients compared to non-COPD patients in nasal, bronchial and lung ... See full document
195
Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension
... Similarly, the complexity of miR-214 functioning in various diseases and tissue counts on different downstream signaling and targets provides a novel prospect for future investigations into the topic. In this study, we ... See full document
11
Associations of autophagy with lung diffusion capacity and oxygen saturation in severe COPD: effects of particulate air pollution
... pollution-associated pathogenesis of COPD is not yet fully ...in COPD sub- jects due to PM 10 , 2) expressions of IL-6, RAGE, ubiquitin, and beclin 1 in COPD subjects were altered by PM 10 , ... See full document
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<p>Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages</p>
... mode, necroptosis has been shown to be involved in retinal degeneration, brain impact trauma, liver injury, and septic shock, and so ...21 Necroptosis execution depends on RIPK1 and 3 activation and it can ... See full document
9
PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
... including mitophagy, has been implicated to IPF patho- genesis, and special attention has been paid to PINK1-PARK2-mediated mitophagy in terms of regulat- ing cell fate for both epithelial cells and ... See full document
9
Autophagy, selective autophagy, and necroptosis in COPD
... Thus, accumulating evidence demonstrates that autophagy plays previously unforeseen roles in COPD pathogenesis and that it can have both protective and injurious effects on COPD progression. Although ... See full document
8
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
... signaling contributes to the broader immune response to ...with pathogenesis in Ross River virus-infected mice (41) and some influenza virus infections (34), and it is likely that complement deposition ... See full document
15
A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae
... during pathogenesis of disease at 48, 72 and 96 h ...during pathogenesis differed mainly in blood: more GO groups were activated in WCH43 (Figure 4, C and D), suggesting that these activated GO groups may ... See full document
9
COPD management costs according to the frequency of COPD exacerbations in UK primary care
... total COPD management costs and its cost components increased with increasing level of disease ...severe COPD patients having higher comorbidities and thus requiring more GP interactions and non-COPD ... See full document
9
Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis
... ROS-promoted mitophagy on apoptosis ...of mitophagy and cytochrome c release, the level of ROS degradation had a lesser impact (Additional file 7: Figures S7D and S7E ... See full document
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Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in <em>Saccharomyces cerevisiae</em>
... In this study, we investigated the toxicity of CdTe QDs in S. cerevisiae and found dose- and size-dependent toxicity, with larger-sized CdTe QDs (O-CdTe QDs) inhibiting cell growth. In addition, experiments using ... See full document
13
Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
... Oxidative stress has been proposed as a relevant event in the pathogenesis of FM [3,12]. In a previous work, we showed the presence of high levels of ROS production in the BMCs of FM patients [5]. To assess the ... See full document
11
Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis
... EAN is characterized by the accumulation of activated T cells and macrophages in the peripheral nerve system. The rapid weight loss (Fig. 2), which cannot be com- pletely explained by the disease-associated paralysis ... See full document
13
Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents
... Effect of exogenous leptin on behavioral and cellular changes. (A–D) Intrathecal leptin (50 μ g) treatment in naive rats, given once daily for 7 days, induced thermal hyperalgesia (A) and mechanical allodynia (B) on day ... See full document
11
IL 33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
... Although we can merely speculate about the initial source of IL-33 to induce MPN-like disease in styx mice, the BM stroma emerges as a valid local provider of this cytokine, since IL-33 is expressed in the niche. ... See full document
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