[PDF] Top 20 Modeling the blood–brain barrier using stem cell sources
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Modeling the blood–brain barrier using stem cell sources
... improve barrier function as measured by increases in TEER and decreases in passive permeability ...adult brain pericytes by Dore-Duffy and colleagues [51], several studies high- lighted the ability of ... See full document
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Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells
... the blood-brain barrier ...specialized brain microvascular endothelial cells (BMECs) that function to separate the circulation from the CNS and act as a for- midable barrier for toxins ... See full document
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Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells
... constructed using primary BMECs isolated from rat, bovine, and por- cine sources ...neurons, cell types known to enhance the BBB phenotype and thereby more accurately recapitulate the in vivo ... See full document
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The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6
... The steps of bone marrow mesenchymal stem cell (BMMSC) isolation were prepared as described previ- ously [25]. MSCs were isolated from the bone marrow of the femur and tibia of the 5-week-old male Sprague– ... See full document
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An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
... and brain- like pericytes that can be combined to generate an enhanced in vitro NVU model with elevated barrier and reduced nonspecific transcytosis ...the cell types is derived from the same human ... See full document
12
Blood–brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow
... that stem cells are promising therapeutic agents for brain regeneration and ...the brain ventricles of spina bifida ...of stem cells into brain of hydro- cephalic foetuses would result ... See full document
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Mechanisms underlying dental-derived stem cell-mediated neurorestoration in neurodegenerative disorders
... mesenchymal stem cell; Bax: B-cell lymphoma 2-associated X protein; BBB: Blood – brain barrier; Bcl-2: B-cell lymphoma 2; BDNF: Brain-derived neurotrophic factor; ... See full document
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Original Article Bone marrow mesenchymal stem cells ameliorate neurological deficits and blood-brain barrier dysfunction after intracerebral hemorrhage in spontaneously hypertensive rats
... BM-MSCs are emerging as therapeutic candi- date in a variety of disease including stroke [8]. Because the multipotent cells are easily isolat- ed from bone marrow and expanded rapidly in vitro [22]. Previous studies have ... See full document
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Mesenchymal stem cells stabilize the blood–brain barrier through regulation of astrocytes
... for activated neutrophils. There was a marked increase in MPO-positive cells in LPS-induced animals; however, MSC treatment following LPS administration notably decreased these cells (Fig. 4a). Stereological analysis ... See full document
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Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
... associated brain injury [100–103]—and EVs from sev- eral sources carry junctional proteins including CLN-5 [75, 104–107], hES-MSC-derived EVs were analyzed for CLN-5 ... See full document
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Complement activation in the injured central nervous system: another dual-edged sword?
... rapid and dramatic breakdown of the BBB/BSB. As a re- sult, the immune-privileged CNS parenchyma, with rela- tively low endogenous expression of complement and associated negative regulators, is exposed to the full force ... See full document
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Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis
... NSCs-566RSC cell line after injec- tion of around 8 × 10 5 cells into the lumbar spinal cord of SOD1 G93A rats at a pre-symptomatic disease stage ...and brain-derived neurotrophic factor (BDNF), which in ... See full document
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Mannitol and the blood-labyrinth barrier
... perilymph, blood and CSF were collected from 44 Dunkin-Hartley guinea pigs (Charles River Breeding Lab, Senneville) with jugular vein catheters placed for intravenous ...and blood before it was terminally ... See full document
7
Current Strategies for Brain Drug Delivery
... Many molecules have demonstrated the ability to transiently open the BBB and allow high concentrations of systemically administered chemotherapeutics to reach the brain [61]. One of the rationales for these ... See full document
13
B cell exchange across the blood brain barrier in multiple sclerosis
... B cell depletion using therapeutic anti-CD20 monoclo- nal antibodies provide additional evidence that B cells are centrally involved in the MS disease process (6, ...B cell depletion, and not ... See full document
12
Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017
... the brain and retina form an impermeable but selective barrier between the blood and the neural ...the blood–brain/retinal barrier, strictly limits the passage of solutes and ... See full document
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Trojan Horse Transit Contributes to Blood Brain Barrier Crossing of a Eukaryotic Pathogen
... thin cell monolayer with mini- mal cytosolic overlap and well-developed junctions ...endothelial cell (panel 4), but with a marked loss of refractility compared to the early ...phagocytic cell ... See full document
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Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
... express cell surface molecules of PSGL-1, VLA-4, and LFA-1 that bind with the corresponding cell adhesion molecules, MAdCAM, VCAM, and ICAM expressed on the brain capillary endothelium and permeate ... See full document
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Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood–brain barrier penetration capabilities
... the blood to the ...investigated using a biomimetic BBB model, which was constructed using RBMECs and astrocytes, corresponding to the anatomical situation in brain ... See full document
12
The hCMEC/D3 cell line as a model of the human blood brain barrier
... underlies brain changes in experimental auto- immune encephalomyelitis in the rat, a model of mul- tiple sclerosis, as well as in rat monocytes and rat brain endothelial cells in vitro, suggesting that it ... See full document
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