[PDF] Top 20 Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4
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Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4
... HPV E4 gene is clearly linked to cellular differentiation status (6, 9, 10, 13, 14, 36, ...The E4 open reading frame is located in the region of early viral genes, such as E1 and E2, even though other ... See full document
7
Identification of an Arginine-Rich Motif in Human Papillomavirus Type 1 E1^E4 Protein Necessary for E4-Mediated Inhibition of Cellular DNA Synthesis In Vitro and in Cells
... basal cell compartment of squamous ...per cell) episome in synchrony with the replication of the host cell genome, a process that requires HPV E1 and E2 ...stimulating cell cycle entry ... See full document
9
Identification of a G2 Arrest Domain in the E1∧E4 Protein of Human Papillomavirus Type 16
... ∧ E4 contains a stretch of amino acids fitting the criteria for a clas- sical nuclear localization signal (NLS), ...∧ E4 immunostaining shows a cytoplasmic localization, it is possible that the 16E1 ∧ ... See full document
13
Role of Calpain in the Formation of Human Papillomavirus Type 16 E1^E4 Amyloid Fibers and Reorganization of the Keratin Network
... HPV type 1 E1 E4 pro- tein suggest that the full-length protein is processed into shorter forms as the cells move toward the surface of the epithelium (2, ...E1 E4 proteins are to form amyloid ... See full document
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The Role of Protein Kinase A Regulation of the E6 PDZ-Binding Domain during the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 18
... life cycle, organo- typic raft cultures of the various cell lines were grown, and paraf- fin-embedded formalin-fixed sections were stained with hema- toxylin and eosin ...spinous cell layers and ... See full document
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Role for Wee1 in Inhibition of G2-to-M Transition through the Cooperation of Distinct Human Papillomavirus Type 1 E4 Proteins
... for E4 function is only beginning to be evaluated, and this and our previous studies (19, 39, 42) have shown that PTM of the HPV1 E4 protein has consider- able impact on its ...of E4 proteins of ... See full document
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Silencing of Integrated Human Papillomavirus Type 18 Oncogene Transcription in Cells Expressing SerpinB2
... life cycle is currently unclear ...of cell lysates. Lanes 3 and 4 represent Weri cell lysates incubated with labeled probe and a 100-fold excess of unlabeled ... See full document
11
Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA.
... ∧ E4 were previously reported (30), and our results are in agree- ment ...cancer-derived cell lines but were not sequenced or otherwise characterized ...∧ E4, E6*I,E7,E1 ∧ E4, E6*II,E7,E1 ∧ ... See full document
6
Detection of Human Papillomavirus Type 18 E7 Oncoprotein in Cervical Smears: a Feasibility Study
... and 18 was separated by SDS-PAGE and analyzed by Western blotting using RabMAb ...HeLa cell populations probably reflects changes in the cell cycle state of such cells ... See full document
12
Temporal Usage of Multiple Promoters during the Life Cycle of Human Papillomavirus Type 31b
... Human papillomaviruses (HPVs) are small DNA viruses that have a tropism for squamous epithelium (45). More than 75 types of HPVs have been identified (32), with subsets caus- ing benign and malignant tumors of the ... See full document
8
The E1∧E4 Protein of Human Papillomavirus Type 16 Associates with a Putative RNA Helicase through Sequences in Its C Terminus
... ∧ E4 proteins of some HPV types can self- associate, no cellular E4-binding proteins have been reported, and the role of E1 ∧ E4 has not been ...∧ E4 with IF is probably mediated indirectly ... See full document
15
Construction of a Full Transcription Map of Human Papillomavirus Type 18 during Productive Viral Infection
... Total cell DNA or RNA extracted from HPV18-infected human primary vaginal keratinocytes (HVK) in monolayer cultures (mono) at passage 11 (P11) or 18 (P18) and their derived, 10-day-old raft tissues ... See full document
13
Cooperation between Different Forms of the Human Papillomavirus Type 1 E4 Protein To Block Cell Cycle Progression and Cellular DNA Synthesis
... the E4-17K and E4-16K proteins were expressed in similar amounts as in cultures infected with ...7. E4-16K induces rereplication of the cellular ...d). E4-16K-expressing cells contain large ... See full document
14
Human Papillomavirus Type 16 E1∧E4 Contributes to Multiple Facets of the Papillomavirus Life Cycle
... ∧ E4 contributes to plasmid DNA replication in the context of the nonproductive infective ...∧ E4 can stimulate the activity of the papillomaviral early protein ...dividing cell populations. E1 ∧ ... See full document
16
The Human Papillomavirus Type 18 E2 Protein Is a Cell Cycle-Dependent Target of the SCFSkp2 Ubiquitin Ligase
... deregulating cell prolif- eration (9, 18, 23, 24, ...host cell genome, leading to disruption of the E2 open reading frame and uncontrolled E6 and E7 expression ... See full document
8
Role of the E1∧E4 Protein in the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 31
... ∧ E4 mutant ge- nomes were digested with the restriction enzyme DpnI to de- grade any residual input ...wild type for early passages, but upon further passaging, a majority of inte- grated copies were ... See full document
9
Cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region in transgenic mice and its modulation by tetradecanoyl phorbol acetate and glucocorticoids.
... 4E for line 411, whereas no activity was detected in control explants from nontransgenic mice data not shown, thus suggesting a different transcription regulation of the transgene in fib[r] ... See full document
11
Human papillomavirus type 18 infection in a female renal allograft recipient: a case report
... for human papillomavirus consensus ...high-risk human papillomavirus type 18 and expression of E6 and E7 oncogenes in her cervical swab and urine ...of human ... See full document
5
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1.
... From the results that Oct-1 can efficiently repress the HPV18 enhancer in HPV18-negative C33 cervical carcinoma cells as well as in primary human dermal fibroblasts, we conclude that Oct[r] ... See full document
6
Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins
... PDZ domains are approximately 80-aa modular units that mediate protein-protein interactions (6, 7). PDZ domain-con- taining proteins represent a diverse family of polypeptides that contain single or multiple PDZ domains, ... See full document
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