[PDF] Top 20 Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
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Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is the likely etiological agent of Kaposi’s sarcoma and primary effusion ...KSHV. Viral ... See full document
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Acetylation of the Latency-Associated Nuclear Antigen Regulates Repression of Kaposi's Sarcoma-Associated Herpesvirus Lytic Transcription
... numerous cellular factors that regulate transcription, chromatin association, and cell cycle progression ...the cellular telomerase gene (32, ...through cellular coactivators and core- ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence
... or cellular genome has recently been ...the viral genome and their epigenetic modification, as well as the methylation of KSHV DNA, occur after entry of the virus into the cell and upon circularization of ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Prolongs the Life Span of Primary Human Umbilical Vein Endothelial Cells
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is a mem- ber of the gammaherpesvirus subfamily, which is the group of herpesviruses known to be associated with cellular prolifera- tion ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Modulates K1 Expression through Its cis-Acting Elements within the Terminal Repeats
... RTA expression vector re- vealed that there was a negligible change in RTA-mediated responsiveness, suggesting that Sp1 sites were not the critical sites for modulation ...of cellular Oct-1 to ... See full document
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Reduction of Kaposi’s Sarcoma-Associated Herpesvirus Latency Using CRISPR-Cas9 To Edit the Latency-Associated Nuclear Antigen Gene
... mRNA expression of a targeted gene should not be directly impacted, and any decrease in mRNA would be a result of the decrease in its template DNA ...mRNA expression slightly in- creased after ... See full document
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DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... By gene expression profiling, we have shown that LANA can positively or negatively modulate transcription of viral and cellular genes ...LANA expression vector pcDNA3/LANA into 293 ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial Cells
... protein expression in KS, normal human microvascu- lar ECs were infected with KSHV using the method described by Ciufo et ...show cellular morphology. (B) Western blot analysis of Id-1 expression in ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65
... LANA-1 expression impairs neutrophil ...degraded nuclear p65 and repressed endothelial IL-8 expression upon TNF- ␣ ...LANA-1 expression on neutrophil chemotaxis using a modified Boyden chamber ... See full document
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Functional Dissection of Latency-Associated Nuclear Antigen 1 of Kaposi's Sarcoma-Associated Herpesvirus Involved in Latent DNA Replication and Transcription of Terminal Repeats of the Viral Genome
... LANA1 expression vector into 293T cells, and a transient reporter assay was performed like that described ...the viral trans- and cis-acting el- ements of KSHV latent replication result in KSHV oriP activ- ... See full document
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Regulation of the Interaction between Glycogen Synthase Kinase 3 and the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
... known properties were generated and shown to be expressed comparably to wild-type HA–GSK-3 (Fig. 1A). The GSK- 3(F291L) mutation causes a 90% loss of GSK-3 binding to axin and to Frat-1, which binds to the same domain of ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Multifunctional Angiogenin To Utilize Its Antiapoptotic Functions
... 28 cellular proteins that were im- munoprecipitated by both proteins, which implied that LANA-1 and ANG are present in a complex with other ...ANG gene by ...target gene of p53, less Mdm2 protein was ... See full document
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... survivin expression in KSHV-infected cells were higher, proliferation assays were ...LANA expression is at a relatively high level were infected with lentivirus carrying sh-SV that specifically knocks down ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
... Brd4 interacts directly with the LANA C terminus. Several LANA-interacting proteins have been identified previously, and most were shown to interact with LANA in cellular or reticulocyte lysates (10, 30, 33, 36, ... See full document
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Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus
... which expression of the endogenous 45-kDa K15 protein could be observed in the context of the entire viral genome, we decided to study its function in epithelial ...and viral transmission in vivo and ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces a Strong Bend on Binding to Terminal Repeat DNA
... both viral and bacterial systems, and it is likely that distortion of DNA within the origin is a necessary step in the initiation of DNA replication (8, 17, 24, 30, 33, ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency-Associated Nuclear Antigen Regulates the KSHV Epigenome by Association with the Histone Demethylase KDM3A
... histone binding motifs, such as the Tudor domain or PHD finger, in the LANA protein sequence. LANA is known to bind histones through an acidic patch on H2B (56), which may facilitate the initial recruitment of the ... See full document
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The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen.
... The characteristic Western blot pattern of LNA is a doublet of approximately 226- to 234-kDa in HBL-6 or BC-1 cells and a slightly lower molecular mass (approximately 220- to 230- kDa) in BCP-1 cells. This size ... See full document
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Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen.
... recombinant antigen for use in serologic tests for antibodies to Kaposi’s sarcoma (KS)- associated herpesvirus ...small viral capsid antigen (sVCA) was identified by immu- ... See full document
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Determination of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal Latency-Associated Nuclear Antigen Residues Mediating Chromosome Association and DNA Binding
... Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen (LANA) tethers viral terminal repeat (TR) DNA to mitotic chromosomes to mediate episome ... See full document
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