[PDF] Top 20 Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
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Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
... Construction of full-length NC and C genomes. Two full-length HCV genomes of genotype 1b were cloned by reverse transcription-PCR (RT-PCR) methodol- ogies from serum and total liver RNA of a chronically infected ... See full document
9
Modulation of Hepatitis C Virus Genome Encapsidation by Nonstructural Protein 4B
... the NS4B protein plays a role in post-HCV replication steps during HCV ...JFH1 NS4B (N216A) had no impact on genome replication but significantly increased the infectious virus ...basic NS4B ... See full document
14
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells.
... GB hepatitis agents, suggesting that this region may be involved in genome ...trans-acting proteins involved in RNA strand replication and possibly constituting cis-regula- tory elements necessary for ... See full document
9
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.
... Two proteins, a 56-kDa protein (p56) and a 58-kDa protein (p58), are produced from the hepatitis C virus (HCV) nonstructural region 5A ...both proteins are phosphorylated at ... See full document
7
The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A.
... Hepatitis C virus (HCV) is a causative agent of posttrans- fusion non-A, non-B hepatitis (5, ...viral proteins encoded in the genome, HCV is believed to be a member of the family ... See full document
6
Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus
... RNA virus containing an open reading frame (ORF) encoding a single polypeptide chain, which is cleaved into structural (core, E1, E2, and p7) and nonstructural (NS2, NS3, NS4A, NS4B, ... See full document
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All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding
... Hepatitis C virus (HCV) is a human pathogen which chron- ically infects nearly 3% of the world’s population (36, ...chronic hepatitis which can progress to liver cirrhosis and, in the worst ... See full document
11
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
... the NS3 serine protease (4, 19, 50) which is incorporated as an integral component into the amino-terminal -barrel of the enzyme core (44, ...hydrophobic NS4B protein is unknown. How- ever, NS4B ... See full document
14
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
... vaccinia virus vTF7-3 ...against NS3 (7019 from Maine Biotech; now available as 1878 from ViroStat, Portland, ME), NS4B (4B-52) (25), NS5A (9E10) (42), NS5B ... See full document
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Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing.
... No NS4B or NS5A could be detected by a -NS4B or a -NS5A, respectively, while an 85-kDa polyprotein (p85) was detected by a ...of NS4B and NS5A, this polypeptide was likely to be ... See full document
7
An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A.
... enveloped virus which contains a positive-stranded RNA ge- nome of about 9,500 nucleotides (10, 26, ...nine proteins (20, 21, ...structural proteins. These include the nucleocapsid C protein ... See full document
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Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A
... Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular ...(NS) proteins (17, 34). Most of the NS proteins (NS2, NS3, ... See full document
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A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
... H77 NS4B is not functional for Con1 RNA replication. NS4B is one of the more divergent nonstructural proteins, and the NS4B proteins from the closely related genotype 1 strains ... See full document
13
Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
... HCV proteins from HCV genotype 1b to analyze antibody responses against indi- vidual viral proteins in patients suffering from chronic infection caused by HCV genotypes 1, 2, 3 or ...HCV proteins ... See full document
12
Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
... and NS4B are required in cis for NS5A hyperphos- ...that NS3 must be expressed in cis with ...of NS3 in cis with NS5A is sufficient for the formation of ...fused NS3 directly to ... See full document
8
Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation.
... the NS4B/5A junction apparently was not affected ...and NS4B-5A intermediate, indicating a reduced processing efficiency, were found with the proteinase lacking 15 amino acids ...truncated NS3 with ... See full document
10
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins.
... HCV NS4A protein acts as a cofactor for the NS3 serine proteinase-mediated cleavage at several sites in the nonstructural ...of NS4A in these proteolytic processing events is still ...that ... See full document
7
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.
... HCV NS3 and NS3-NS4A proteinases could play an important regulatory role in viral ...Since NS3 and NS4A may form a complex after cis cleavage at the 3/4A site and NS4A ... See full document
8
Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation
... were cotransfected with pRK-Flag-CK1 ␣ and pRK-HA-vinexin  (W307F/Y325V) or ⌬ 3rd SH3. At 36 hpt, cell lysates were immunoprecipitated with a mouse anti-Flag MAb ( ␣ -F) and bound proteins and original lysates ... See full document
16
Selection of Functional Variants of the NS3-NS4A Protease of Hepatitis C Virus by Using Chimeric Sindbis Viruses
... the NS3-NS4A complex but is dispensable for activation of the protease ...of NS4A was postulated to be responsible for the membrane anchoring of the NS3-NS4A complex ...mutated ... See full document
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